2002 Fiscal Year Final Research Report Summary
Thp relation with nathnlogiral maliRnancyof oral carcinoma and telomerase activity
| Project/Area Number |
13672123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | TOKYO DENTAL COLLEGE |
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Principal Investigator |
HATADA Kenichi TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY, ASSISTANT, 歯学部, 助手 (00256299)
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| Project Period (FY) |
2001 – 2002
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| Keywords | oral carcinoma / telomerase activity / pathological malignancy / SQliamoUS cel l carcinoma / luorescence-based T.R.A.P |
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| Research Abstract |
Telomerase, a ribonucleoprotein enzyme associated with cell immortalization, is considered to be expressed specifically in germ line and cancerous cells. It is reported that telomerase is expressed in more than 90% of malignant tumors derived from the oral cavity regardless of histological type.
To determine whether the detection of telomerase activity can be a useful marker for detecting malignant progression in borderline lesions of oral carcinomas, and to examine possible association between telomerase activity and histological grade of malignancy, the status of telomerase activity during the development of oral squamous cell carcinoma was assessed and compared with histopathological findings. Telomerase activity was assessed using Fluorescence-based telomeric repeat amplification protocol assay.
We investigated the relation with pathological malignancy of oral carcinoma andtelomerase activity.
In comparison the normal part with the tumor part, telomerase activity of the tumor part was significantly high.Telomerase activity was 52.7U/jUgP in squamous cell carcinoma, 2.9 U/jUgP in nomal epithelium. The statistical significant difference was not recognized between telomerase activity and malignant degrees of histology, but the tumor that malignancy degree was high, showed the high telomerase activity.
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Research Products
(2 results)
