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2002 Fiscal Year Final Research Report Summary

Study on the actual state of latex allergy in healthcare personnel and children in Toyama prefecture, and an attempt to develop a low allergic latex

Research Project

Project/Area Number 13672448
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 基礎・地域看護学
Research InstitutionTOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

Principal Investigator

OCHIAI Hiroshi  Toyama Medical and pharmaceutical University, Faculty of Medicine, Professor, 医学部, 教授 (30018692)

Co-Investigator(Kenkyū-buntansha) TERANISHI Toyohide  Toyama Medical and pharmaceutical University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (40115184)
YATSUZUKA Miki  Toyama Medical and pharmaceutical University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (00293291)
Project Period (FY) 2001 – 2002
Keywordslatex allergy / latex-sensitized group / high risk / powder-free gloves / low allergic latex / proteoloytic enzime / FgE / survey
Research Abstract

We studies on the actual state of latex allergy through the analyses of answers on the questionnaire obtained from 641 healthcare personnel including 580 nurses and 405 children with the mean age of 12.6 years in Toyama prefecture. The main findings are summarized as follows.
1. By the analyses of answers of healthcare personnel, 20.7% of the responders were latex-sensitized group(LSG). Especially, younger nurses and nurses working in the operation theater were considered to be at the high risk of LSG. Two nurses were diagnosed as latex allergy by the serological test. Half of healthacre facilities have not yet avoided to use the powder-free latex gloves. To control their symptoms, as much as 79% of responders in LSG used lotion or humidified cream which are thought to facilitate to latex allergy.
2. By the analyses of answers of children, 80 children(19.8%) were LSG. LSG was 4.55 years younger and showed a significantly higher prevalence rate of allergic diseases than the remaining 325 children. Most children in LSG cited sticking plaster, and rubber gloves and balloons as allergy-realted latex products. To control their symptoms, they avoided the use of causative latex products or consulted with doctors, but no children received diagnostic tests of latex allergy.
3. Western blotting analysis using a latex specific IgE -positive serum showed that two bands corresponding to Hev B1 and Hev B7 could be detected before the treatment of latex proteins with trypsin or papain(37 C, for 1 h), but not after the treatment. This findings strongly that enzyme treatment of latex might be useful to prepare low allergic latex products.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 鴻巣聡子, 八塚美樹, 今西信子, 丸橋美友紀, 片田裕子, 吉井美穂, 寺西秀豊, 落合宏: "富山県医療従事者のラテックスアレルギーに関する調査研究"富山医科薬科大学看護学会誌. 4. 115-126 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 八塚美樹, 鴻巣聡子, 今西信子, 佐藤美友紀, 片田裕子, 上田京桂, 寺西秀豊, 落合宏: "富山県内若年者のラテックスアレルギーに関する実態調査と低アレルゲンラテックス作製の試み"富山医科薬科大学看護学会誌. 5(印刷中). (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Konosu S., Yatsuzuka M., Imanishi K., Maruhashi M., Katada Y., Yoshii M., Teranishi T., and Ochiai H.: "Study on the actual state of latex allergy control in healthcare personnel in Toyama prefecture, Japan."Journal of Nursing Society of Toyama Medical and Pharmaceutical University. 4. 115-126 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yatsuzuka M., Konosu S., Imanishi N., Sato M., Katada Y., Ueda K., Teranishi T., and Ochiai H.: "Epidemiological study on the latex-sensitized children in Toyama prefecture, and an attempt to develop a low allergic latex protein by proteolytic enzyme treatment."Journal of Nursing Society of Toyama Medical and Pharmaceutical University. 5. (in press) (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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