2014 Fiscal Year Annual Research Report
| Project/Area Number |
13F03038
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| Research Institution | The University of Tokyo |
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Principal Investigator |
吉田 亮 東京大学, 工学(系)研究科(研究院), 教授 (80256495)
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| Co-Investigator(Kenkyū-buntansha) |
JIMENEZ Zulma 東京大学, 工学(系)研究科(研究院), 外国人特別研究員
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 高分子 / 機能性材料 / 相転移 / 自己集合 |
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| Outline of Annual Research Achievements |
We report a zwitterionic block copolymer composed of N-isopropylacrylamide and N,N-dimethyl-N-(3-(methacrylamido)propyl) ammoniopropane sulfonate monomers which self-assembles into different structures depending on the solution temperature. As the temperature is increased from 20 °C to 70 °C, the solubility of the polymer switches direction from insoluble to soluble to insoluble to soluble. During this process, the polymer self-assembly changes from polymersomes to micelles. These extraordinary transitions are possible because of the hydrophilic-hydrophobic ratio of the polymer blocks and the presence of a carbonyl group attached to the end of the poly(N-isopropyl acrylamide) chain. Additionally, one of these transitions can be controlled by the pH of the solution thanks to the protonation-deprotonation of the carbonyl and the charge neutralization of the ammonium moieties. The present work opens the possibility of designing polymers with temperature driven self-assembly properties that could be used for biomedical applications.
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| Research Progress Status |
26年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
26年度が最終年度であるため、記入しない。
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Research Products
(2 results)
