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2007 Fiscal Year Annual Research Report

幹細胞の可塑性と未分化性維持機構

Research Project

Project/Area Number 14081101
Research InstitutionThe University of Tokyo

Principal Investigator

中内 啓光  The University of Tokyo, 医科学研究所, 教授 (40175485)

Co-Investigator(Kenkyū-buntansha) 丹羽 仁史  理化学研究所, 多能性幹細胞研究, チームリーダー(研究職) (80253730)
横田 崇  金沢大学, 医学系研究科, 教授 (50134622)
Keywords幹細胞 / 未分化性維持機構 / 再生医療 / テクノロジー
Research Abstract

本特定領域研究では1)細胞の初期化の機構の解明、2)幹細胞の未分化性維持機構、3)幹細胞の多様性と可塑性の三つの柱を中心に5年間にわたり研究を進めた。ES細胞、組織幹細胞のそれぞれにおいて研究が大きく進展したが、最近2年間に本特定領域研究の分担研究者である山中伸弥教授らによって遺伝子導入によって体細胞を多能性幹細胞に変換する技術が開発され、再生医療・幹細胞研究に大きな転換を迎える事態となったことは特筆すべきことである。厳しいガイドラインのため本邦においてはヒトES細胞研究が諸外国と比して進展に遅れていたが、倫理的問題を含まないiPS細胞技術の登場により、多能性幹細胞の分野にも今後大きな研究の進展が見込まれる。そこで昨年度は新しく開発されたiPS細胞産生技術を中心に「幹細胞研究を支える新しいテクノロジー」というテーマのもとでシンポジウムを開催した。産業界を含む300名近い研究者が参加し意見を交換することにより、本研究領域における研究で得られた知見を速やかに共有することができた。また、総括班メンバーを中心に今後の幹細胞研究の進め方などについても討議がなされた。

  • Research Products

    (21 results)

All 2008 2007 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results)

  • [Journal Article] Interleukin-27 directly induces differentiation in hematopoietic stem cells.2008

    • Author(s)
      Seita J, et. al.
    • Journal Title

      Blood. 111

      Pages: 1903-12

    • Peer Reviewed
  • [Journal Article] The WAVE2/Abil complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery.2007

    • Author(s)
      Eto K, et. al.
    • Journal Title

      Blood. 110

      Pages: 3639-47

    • Peer Reviewed
  • [Journal Article] Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.2007

    • Author(s)
      Chiba T, et. al.
    • Journal Title

      Gastroenterology. 133

      Pages: 937-50

    • Peer Reviewed
  • [Journal Article] Foxo3a is essential for maintenance of the hematopoietic stem cell pool.2007

    • Author(s)
      Miyamoto K, et. al.
    • Journal Title

      Cell Stem Cell. 1

      Pages: 101-12

    • Peer Reviewed
  • [Journal Article] The plasminogen fibrinolytic pathway is required for hematopoietic regeneration.2007

    • Author(s)
      Heeissig B, et. al.
    • Journal Title

      Cell Stem Cell. 1

      Pages: 658-70

    • Peer Reviewed
  • [Journal Article] Cdlcnla deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.2007

    • Author(s)
      Choudhury, A. R., et. al.
    • Journal Title

      Nat Genet. 39

      Pages: 99-105

    • Peer Reviewed
  • [Journal Article] De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.2007

    • Author(s)
      Tadokoro, Y, et. al.
    • Journal Title

      J Exp Med. 204

      Pages: 715-22

    • Peer Reviewed
  • [Journal Article] Characterization of GATA-1^+ hemangioblastic cells in the mouse embryo.2007

    • Author(s)
      Yokomizo T, et. al.
    • Journal Title

      EMBO J. 26

      Pages: 184-196

    • Peer Reviewed
  • [Journal Article] Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development.2007

    • Author(s)
      Suzuki A, et. al.
    • Journal Title

      Development. 134

      Pages: 77-83

    • Peer Reviewed
  • [Journal Article] ES cell culture as a tool for developmental cell biology.2007

    • Author(s)
      Nishikawa S-I, et. al.
    • Journal Title

      Nature Rev Mol Cell Biol. 8

      Pages: 502-7

    • Peer Reviewed
  • [Journal Article] Neuroepithelial cells supply an initial transient wave of MSC differentiation.2007

    • Author(s)
      Takashima Y, et. al.
    • Journal Title

      Cell. 129

      Pages: 1377-88

    • Peer Reviewed
  • [Journal Article] Identification of long-term repopulating potential of human cordblood-derived CD34^-flt3^- severe combined immunodeficiency-repopulating cells by intra-bone marrow injection.2007

    • Author(s)
      Kimura T, et. al.
    • Journal Title

      Stem Cells. 25

      Pages: 1348-55

    • Peer Reviewed
  • [Journal Article] Gene and cell therapy for relapsed leukemia after allo-stem cell transplantation.2007

    • Author(s)
      Onodera M, et. al.
    • Journal Title

      Gene Therapy.

      Pages: 286-94

    • Peer Reviewed
  • [Journal Article] Reciprocal targeting of Hath1 and β-catenin by Wnt-glycogen synthase kinase 3β in human colon cancer.2007

    • Author(s)
      Tsuchiya K, et. al.
    • Journal Title

      Gastroenterology. 132

      Pages: 208-20

    • Peer Reviewed
  • [Journal Article] Mitochondrial bottleneck occurs without reduction of mtDNA content in mouse female germ cells.2007

    • Author(s)
      Cao L, et. al.
    • Journal Title

      Nat. Genet. 39

      Pages: 386-90

    • Peer Reviewed
  • [Journal Article] Successful reconstruction of human endometrium from singly dispersed endometrial cells in the severe immunodeficient mouse: its potenital application as endometriosis model.2007

    • Author(s)
      Masuda H, et. al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 104

      Pages: 1925-30

    • Peer Reviewed
  • [Journal Article] Single-cell-derived mesenchymal stem cells overexpressing Csx/Nkx2.5 and GATA4 undergo the stochastic cardiomyogenic fate andbehave like transient amplifying cells.2007

    • Author(s)
      Yamada Y, et. al.
    • Journal Title

      Exp Cell Res. 313

      Pages: 698-706

    • Peer Reviewed
  • [Journal Article] The Significant Cardiomyogenic Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Vitro.2007

    • Author(s)
      Nishiyama N, et. al.
    • Journal Title

      Stem Cells.

    • Peer Reviewed
  • [Journal Article] 'Working' cardimyocytes exhibiting plateau action potentials from human placenta-derived extraembryonic mesodermal cells.2007

    • Author(s)
      Okamoto K, et. al.
    • Journal Title

      Exp Cell Res. 313

      Pages: 2550-63

    • Peer Reviewed
  • [Journal Article] Isolation of mouse pancreatic ductal progenitor cells expressing CD133 and c-Met by flow cytometric cell sorting.2007

    • Author(s)
      Oshima Y, et. al.
    • Journal Title

      Gastroenterology. 132

      Pages: 720-32

    • Peer Reviewed
  • [Journal Article] Generation of functional platelets from human embryonic stem cells in vitro via ES-saces, VEGF-promoted structures that concentrate hematopoietic progenitors.

    • Author(s)
      Takayama N, et. al.
    • Journal Title

      Blood. (In Press)

    • Peer Reviewed

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Published: 2010-02-04   Modified: 2016-04-21  

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