• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2004 Fiscal Year Final Research Report Summary

Development of Micro pH Sensor for Diagnosis of Dental Caries Activity

Research Project

Project/Area Number 14207079
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TAGAMI Junji  Tokyo Medical and Dental University, Cariology and Operative Dentistry, Professor, 大学院・医歯学総合研究科, 教授 (50171567)

Co-Investigator(Kenkyū-buntansha) NIKAIDO Toru  Tokyo Medical and Dental University, Cariology and Operative Dentistry, Assistant Professor, 大学院・医歯学総合研究科, 講師 (00251538)
NAKAJIMA Masatoshi  Tokyo Medical and Dental University, Cariology and Operative Dentistry, Assistant Professor, 歯学部付属病院, 講師 (50272604)
KITASAKO Yuichi  Tokyo Medical and Dental University, Cariology and Operative Dentistry, Lecturer, 大学院・医歯学総合研究科, 助手 (30361702)
NOMURA Satoshi  Horiba Ltd., R&D Center, Technical Manager, 基礎技術開発部, 研究統括マネージャー
NAKANISHI Tsuyoshi  Horiba Ltd., R&D Center, 基礎技術開発部, 主任研究員
Project Period (FY) 2002 – 2004
Keywordsactive carious dentin / arrested carious dentin / pH / micro-pH sensor / ISFET / pH-imaging microscope / caries activity / Minimal Intervention
Research Abstract

The pH values of extracted carious and intact dentin have been investigated visually and quantitatively using a pH-imaging microscope (Kitasako et al., 2002). The pH distribution of carious dentin was shown to be lower than that of intact dentin. In addition, there was a significant correlation between a decrease in pH and mineral loss in active dentinal caries lesions (Hiraishi et al.2003). Nakajima et al. (2004) also reported the distributions of the minerals, Ca, P, and Mg, at the adhesive interface to caries-affected dentin were different from normal dentin. However, the pH-imaging sensor is too large for evaluating the pH of caries in the oral cavity directly. A smaller version would allow in vivo pH-imaging characterization of caries lesions in the oral cavity. Recently, a micro-pH sensor using an Ion Sensitive Field Effect Transistor (ISFET) has been developed to overcome the problem of the glass and antimony electrodes (Murakami et al., 2005). Twenty extracted carious teeth were divided into two groups, active or arrested caries. The surface pH values of carious dentin were measured using three methods : surface pH directly measured using the micro-pH sensor ; sectioned teeth using a pH-Imaging microscope or the micro-pH sensor. For all techniques, the lowest pH values of the active and arrested carious dentin (5.3-6.5) were less than those of intact dentin (6.8-7.4). Comparison of pH data from pH-Imaging microscope or micro-pH sensor, which measured the same pH point, a high agreement (p=0.890) was confirmed. For all techniques, there was a statistically significant differences of pH values between active and arrested dentinal caries. Because this micro-pH sensor can evaluate caries activity on each tooth, it might have the potential to aid in assessment of caries lesions and then the subsequent type of clinical management using the concepts of Minimal Intervention.

  • Research Products

    (13 results)

All 2005 2004 2003 2002

All Journal Article (12 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Elemental distributions and microtensile bond strength of adhesive interface to normal and caries-affected dentin.2005

    • Author(s)
      Nakajima M, Kitasako Y, Okuda M, Foxton RM, Tagami J.
    • Journal Title

      Journal of Biomedical Materials Research Part B 72(2)

      Pages: 268-275

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 小型pHセンサーによるヒト抜去う蝕象牙質のう蝕活動性診断2005

    • Author(s)
      村上景子, 北迫勇一, 山貫幹人, 野村聡, 中西剛, 田上順次
    • Journal Title

      接着歯学 23(1)

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Elemental distributions and microtensile bond strength of adhesive interface to normal and caries-affected dentin.2005

    • Author(s)
      Nakajima M, Kitasako Y, Okuda M, Foxton RM, Tagami J.
    • Journal Title

      Journal of Biomedical Materials Research Part B 72-2

      Pages: 268-275

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Diagnosis for dental caries activity of extracted human carious dentin using a micro-pH sensor.2005

    • Author(s)
      Murakami K, Kitasako Y, Yamanuki M, Nomura S, Nakanishi T.
    • Journal Title

      Adhesive Dentistry 23-1

      Pages: 1-8

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Growth-inhibitory effect of antibacterial self-etching primer on mutans Streptococci obtained from arrested carious lesions.2004

    • Author(s)
      Kitasako Y, Senpuku H, Richard MF, Hanada N, Tagami J.
    • Journal Title

      Journal of Esthetic & Restorative Dentistry 16(3)

      Pages: 176-184

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Surface analysis of dentinal caries in primary teeth using a pH-imaging microscope.2004

    • Author(s)
      Nikaido T, Moriya K, Hiraishi N, Ikeda M, Kitasako Y, Foxton RM, Tagami J.
    • Journal Title

      Dental Material Journal 23(4)

      Pages: 628-632

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Growth-inhibitory effect of antibacterial self-etching primer on mutans Streptococci obtained from arrested carious lesions.2004

    • Author(s)
      Kitasako Y, Senpuku H, Richard MF, Hanada N, Tagami J.
    • Journal Title

      Journal of Esthetic & Restorative Dentistry 16-3

      Pages: 176-184

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Surface analysis of dentinal caries in primary teeth using a pH-imaging microscope.2004

    • Author(s)
      Nikaido T, Moriya K, Hiraishi N, Ikeda M, Kitasako Y, Foxton RM, Tagami J.
    • Journal Title

      Dental Material Journal 23-3

      Pages: 628-632

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Evaluation of active and arrested carious dentin using a pH-imaging microscope and an X-ray analytical microscope.2003

    • Author(s)
      Hiraishi N, Kitasako Y, Nikaido T, Foxton RM, Tagami J.Nomura S.
    • Journal Title

      Operative Dentistry 28(5)

      Pages: 598-604

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Evaluation of active and arrested carious dentin using a pH-imaging microscope and an X-ray analytical microscope.2003

    • Author(s)
      Hiraishi N, Kitasako Y, Nikaido T, Foxton RM, Tagami J, Nomura S.
    • Journal Title

      Operative Dentistry 28-5

      Pages: 598-604

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] In vitro surface analysis of active and arrested dentinal caries using a pH-imaging microscope.2002

    • Author(s)
      Kitasako Y, Hiraishi N, Nakajima M, Nikaido T, Tagami J, Nomura S.
    • Journal Title

      Operative Dentistry 27(4)

      Pages: 354-359

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] In vitro surface analysis of active and arrested dentinal caries using a pH-imaging microscope.2002

    • Author(s)
      Kitasako Y, Hiraishi N, Nakajima M, Nikaido T, Tagami J, Nomura S.
    • Journal Title

      Operative dentistry 27-4

      Pages: 354-359

    • Description
      「研究成果報告書概要(欧文)」より
  • [Patent(Industrial Property Rights)] 歯のう蝕罹患リスク評価法およびpHセンサーによる唾液緩衝能評価装置2002

    • Inventor(s)
      田上 順次, 北迫 勇一, 勝村 聡, 本城 充
    • Industrial Property Rights Holder
      堀場製作所
    • Industrial Property Number
      特願2002-107712
    • Filing Date
      2002-04-10
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2006-07-11  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi