2005 Fiscal Year Final Research Report Summary
Study of Transdermal Delivery of Lidocaine by AC Iontophoresis : Interrelationship of frequency, voltage and the concentration of lidocaine in tissue.
| Project/Area Number |
14207088
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
UMINO Masahiro Tokyo Medical and Dental University, Graduate School, Professor, 大学院・医歯学総合研究科, 教授 (90014125)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBAJI Takao Tokyo Medical and Dental University, Dental Hospital, assistant, 歯学部付属病院, 助手 (90323724)
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| Project Period (FY) |
2002 – 2005
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| Keywords | iontophoresis / alternating current / transport efficiency / local anesthesia / sinusoidal wave / non-ionized molecule / macromolecule |
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| Research Abstract |
Iontophoresis is one of electrical methods that have been employed to enhance drug transportation across the skin. This delivery method transports ionized substances through skin or mucous membranes utilizing an electrical force. Iontophoresis using direct current (DC) has been used as a drug delivery method based on the principle. However complications such as skin burning, itching and redness have been associated with DC iontophoresis. Furthermore, the operating time of DC iontophoresis is limited because of the polarization effect.
Alternating current produces less electrode polarization than DC and avoids side effects mentioned above. It was found that AC electric field transport drug more effectively across the skin. We proposed a theoretical model of the mechanism of high frequency AC iontophoresis.
We found that lidocaine could be transported through extirpated abdominal rat skin and cellophane membrane in vivo and in vitro. In vitro we used two cylindrical glass diffusion cells in parallel to the cellophane membrane and extirpated abdominal rat skin, In vivo we developed original drug delivery cell with two platinum circular plates to fit rat skin tightly.
The lodocaine concentration after the application of frequency and voltage increased than passive diffusion significantly.
A sinusoidal wave was used in these studies, but now we are trying to search for the best electrical condition, for example using a square wave.
To transport drugs more effectively we try to develop new cells and apply this system for another drug, non-ionized molecule and macromolecule and so on.
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Research Products
(10 results)
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[Journal Article] Needle Less and Pain Less Local Anesthesia The Influence about Pain Threshold and Feeling of the Skin Under AC Application of the Skin.2005
Author(s)
Kinoshita, T., Haga, H., Ogami, S., Izumikawa, H., Shibaji, T., Umino, M.
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Journal Title
Journal of The Japanese Association for Dental Science 24
Pages: 87-92
Description
「研究成果報告書概要(欧文)」より
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