Molecular Basis of Human Skim and Primate Hair Color Variation

2003 Fiscal Year Final Research Report Summary

• Project/Area Number: 14340273
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 人類学(含生理人類学)
• Research Institution: The University of Tokyo
• Principal Investigator: ISHIDA Takafumi The University of Tokyo, Graduate School of Science, Associate Professor, 大学院・理学系研究科, 助教授 (20184533)
• Project Period (FY): 2002 – 2003
• Keywords: Human / Macaque / Gibbon / Primates / Body Color / Gene

Research Abstract

Population based molecular studies and pharmacological analyses have revealed that the polymorphisms of the MClR are strongly associated with skin color variation in Asians and Oceanians. Nonsynonymous substitutions found in northeastern Asian population reduced cAMP production levels.
Distribution of one of the polymorphisms of the ALMl, Leu374Phe, was exclusively limited to Caucasian stocks, although 374^<Pbe> is ubiquitously found through the plant and vertebrates.
In other primates, such as macaques and gibbons, participation of the MClR and agouti in their coat color determination was suggested with special reference to their ecological and evolutionary status.

Research Products

• [Publications] Nakayama et al.: "Distinctive distribution of AIM 1 polymorphism among major human populations with different skin color."Journal of Human Genetics. 47. 92-94 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Shimizu, Ishida: "Somatic mutations in the p53 gene account for the extention of replicative life-span of macague cells."Biochem.Biophys.Res.Commun.. 295. 644-650 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Shimizu et al.: "In vitro aging of macaque adherent cells : similar pattern of cellular aging between human and macague."Mechanisms of Ageing and Development. 124. 243-250 (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Kimura et al.: "Distribution of a 27-bp deletion in the band 3 gene in South Pacific islanders."Journal of Human Genetics. 48. 642-645 (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Tachikui et al.: "Lineage specific homogenization of the polyubiquitin gene among human and great apes."Journal of Molecular Evolution. 57. 737-744 (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Nakayarna, K., Fukamachi, S., Kimura, H., Koda, Y., Soemantri, Ag., Ishida, T.: "Distinctive distribution of AIMl polymophism among major human populations with different skin color."Journal of Human Genetics. 47. 92-94 (2002)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Shimizu, Y., Ishida, T.: "Somatic mutations in the p53 gene account for the exiention of replicative life-span of macaque cells."Boichem. Biophys. Res. Commun.. 295. 644-650 (2002)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Shimizu, Y., Suzuki, J., Terao, K., Ishida, T.: "In vitro aging of macaque adherent cells: similar pattern of cellular aging between human and macaque."Mechanisms of Ageing and Development. 124. 243-250 (2003)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Kimura, M., Tamam, M., Soemantri, A., Nakazawa, M., Ataka, Y., Ohtsuka, R., Ishida, T.: "Distribution of a 27-bp deletion in the band 3 gene in South Pacific islanders."Journal of Human Genetics. 48. 642-645 (2003)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Tachikui, H., Nakajima, T., Saitou, N., Hayasaka, I., Ishida, T., Inoue, I.: "Lineage specific homogenization of the polyubiquitin gene among human and great apes."Molecular Biology and Evolution. Journal of Molecular Evolution. 57. 737-744 (2003)
  • Description: 「研究成果報告書概要(欧文)」より