2002 Fiscal Year Annual Research Report

分極誘起セラミックスによるナノ制御可能な特異的固体析出操作と表面活性の創出

Research Project

Project/Area Number	14350457
Research Institution	Tokyo Medical and Dental University
Principal Investigator	大柿真毅東京医科歯科大学, 生体材料工学研究所, 助手 (50223748)
Co-Investigator(Kenkyū-buntansha)	中村聡東京医科歯科大学, 生体材料工学研究所, 助手 (40227898) 山下仁大東京医科歯科大学, 生体材料工学研究所, 教授 (70174670)
Keywords	アパタイト / セラミック / ポーリング / 分極誘起 / 固体析出 / 表面活性 / ナノ制御
Research Abstract	本課題研究では、最近分極可能なことを見出したアパタイトセラミックスが特異的な表面活性制御の効果をもたらすという重大な現象を、これまで培った生体材料学的知見を有効に活用しながらナノレベルの表面活性反応場に着目し研究を進めている。本研究の成果は、材料表面の活性を環境関連化学を含む工業化学分野のみならず医用生体工学など広い分野に活かすことができる。本年度の研究は、反応場中におけるアパタイトセラミックス表面の材料学的基礎物性評価と、誘起された表面活性が及ぼす周囲との化学的および生物学的反応性評価とを同時に検討した。基礎物性評価の観点からは、分極処理条件によりポーリングアパタイトセラミックスの蓄積エネルギーが系統的に変化すること、アパタイトの持つ基本構造は変化せずプロトンの移動によつてポーリングするであろうことが明らかになった。さらに、材料表面構造を詳細に明らかにする新しい手法として、従来まで試料の深さ方向で異なる結晶層の同定を行うのみであった薄膜X線解析法を拡張し、各深さの層からの回折X線強度を独立に抽出する方法を模索した。この手法を確立することにより、活性に及ぼす表面の微細な構造変化に関する重要なデータを得られることができると考えられる。一方、表面活性反応場は擬似体液中の固体析出速度を加速するだけでなく生体中でも骨組織を早く再生する可能性があること、in vitroにおける培養細胞の増殖活性を高める効果を持つことが明らかになった。

Research Products

(18 results)

All Other

All Publications (18 results)

[Publications] Kizuki T, Ohgaki M, Nakamura S, Hashimoto K, Toda Y, Yamshita: "Bone-like Layer Formed in Culture Medium as a Scaffold for Cell Activation"Proc. 2nd Asian Bioceram. 53-56 (2002)
[Publications] Ohgaki M, Yamashita K: "Structure Refinement of Inside Layer of Calcium Phosphate Coatings by Thin Dilm X-Ray Piffraction Method"Proc. 2nd Asian Bioceram. 103-106 (2002)
[Publications] Ueshima M, Nakamura S, Ohgaki M, Yamashita K: "Electrovectorial Effect of Polarized Hydroxyapatite on Quasi-epitaxial Growth at Nanointerfaces"Solid State Ionics. 151. 29-34 (2002)
[Publications] Y.Toyama, Ohgaki M, Nakamura S, Katayama K, Yamashita K: "Conformation of Self-assembled Organic Layer on the Electrically Polarized Hydroxyapatite Ceramics in Non-Aqueous Solution"Solid State Ionics. 151. 159-163 (2002)
[Publications] Kizuki T, Ohgaki M, Nakamura S, Hashimoto K, Toda Y, Yamashita: "Synthesis of New Biocompatible Apatite-type Rare-earth Silicates"Bioceramics. 15. 559-562 (2002)
[Publications] Ohgaki M, Nakamura S, Yamashita K: "Inductive Contact and Adherence Manipulation of Osteoblast-like Cell on Polarized Hydroxyapatite Ceramics"Bioceramics. 15. 711-714 (2002)
[Publications] Ueshima M, Tanaka S, Nakamura S, Yamashita K: "Manipulation of bacterial adhesion and proliferation by surface charges of electrically polarized hyfroxyapatite"J Biomed Mat Res. 60. 578-574 (2002)
[Publications] Nakamura S, Kobayashi T, Yamashita K: "Extended Bioactivity in the Proximity of Hydroxyapatite Ceramic Surfaces Induced by Polarization Charges"J Biorned Mat Re. 61. 593-599 (2002)
[Publications] Yamashita K: "Electrovectorial Effect of Electrically Polarized Hydroxyapatite on Biological Phenomena"Phosphorus, Sulfur, Silicon. 177. 1889-1892 (2002)
[Publications] H Takeda, Seki Y, Nakamura S, Yamashita K: "Evaluation of Electrical Polarizability and in vitro Bioactivity of Apatite Sr_5(PO_4)_3OH Dense Ceramics"J Mater Chem. 151. 2490-2495 (2002)
[Publications] Yamashita K, Nakamura S, Kobayashi T: "Electrovector Ceramics for Biomedical Use : Manipulation of Bonelike Crystal Growth in SBF"Ceram. Eng. Sci. Proc. 23. 735-744 (2002)
[Publications] Nakamura S, Kobayashi T, Yamashita K: "Enhanced Osteoconductivity of Hydroxyapatite Ceramics Induced by Proton Transport Polarization Charges"Transport Eng. 6. 102-106 (2002)
[Publications] Nakamura M, Sekijima Y, Kobayashi T, Obata A, Nakamura: "Molecular Biologic Detections of Cell Activation Related Proteins on Bioniaterials"Proc. 2nd Asian Bioceram. 57-60 (2002)
[Publications] Obata A, Nakamura S, Yamashita K: "High Osteoconductive Surface for Bioactive Glass by Electrical Polarization"Bioceramics. 15. 441-444 (2002)
[Publications] Nakatnura S, Ueshima M, Kobayashi T, Yamashita K: "Crystal Growth Modification by Surface Charges on Ceramic Electret in Simulated Body Fluid"Bioceramics. 15. 445-448 (2002)
[Publications] Nakamura M, Sekijima Y, Kobayashi T, Nakamura s: "Molecular Biologic-Detections of Cell Activation Related Proteins on Polarized Hydroxyapatite, Biocermics"Bioceramics. 15. 643-646 (2002)
[Publications] 大柿真毅, 山下仁大: "PMMAにより傾斜機能化した新規ハイドロキシアパタイト複合材料の開発"東医歯大生材研報告. 36. 21-26 (2002)
[Publications] Nakamura S, Kobayashi T, Yamashita K: "Enhanced Osteoconductivity of Hydroxyapatite Ceramics Induced by Proton Transport Polarization Charges"Transport Eng. 6. 102-106 (2002)

2002 Fiscal Year Annual Research Report

分極誘起セラミックスによるナノ制御可能な特異的固体析出操作と表面活性の創出

Principal Investigator

大柿 真毅 東京医科歯科大学, 生体材料工学研究所, 助手 (50223748)

Research Products

[Publications] Kizuki T, Ohgaki M, Nakamura S, Hashimoto K, Toda Y, Yamshita: "Bone-like Layer Formed in Culture Medium as a Scaffold for Cell Activation"Proc. 2nd Asian Bioceram. 53-56 (2002)

[Publications] Ohgaki M, Yamashita K: "Structure Refinement of Inside Layer of Calcium Phosphate Coatings by Thin Dilm X-Ray Piffraction Method"Proc. 2nd Asian Bioceram. 103-106 (2002)

[Publications] Ueshima M, Nakamura S, Ohgaki M, Yamashita K: "Electrovectorial Effect of Polarized Hydroxyapatite on Quasi-epitaxial Growth at Nanointerfaces"Solid State Ionics. 151. 29-34 (2002)

[Publications] Y.Toyama, Ohgaki M, Nakamura S, Katayama K, Yamashita K: "Conformation of Self-assembled Organic Layer on the Electrically Polarized Hydroxyapatite Ceramics in Non-Aqueous Solution"Solid State Ionics. 151. 159-163 (2002)

[Publications] Kizuki T, Ohgaki M, Nakamura S, Hashimoto K, Toda Y, Yamashita: "Synthesis of New Biocompatible Apatite-type Rare-earth Silicates"Bioceramics. 15. 559-562 (2002)

[Publications] Ohgaki M, Nakamura S, Yamashita K: "Inductive Contact and Adherence Manipulation of Osteoblast-like Cell on Polarized Hydroxyapatite Ceramics"Bioceramics. 15. 711-714 (2002)

[Publications] Ueshima M, Tanaka S, Nakamura S, Yamashita K: "Manipulation of bacterial adhesion and proliferation by surface charges of electrically polarized hyfroxyapatite"J Biomed Mat Res. 60. 578-574 (2002)

[Publications] Nakamura S, Kobayashi T, Yamashita K: "Extended Bioactivity in the Proximity of Hydroxyapatite Ceramic Surfaces Induced by Polarization Charges"J Biorned Mat Re. 61. 593-599 (2002)

[Publications] Yamashita K: "Electrovectorial Effect of Electrically Polarized Hydroxyapatite on Biological Phenomena"Phosphorus, Sulfur, Silicon. 177. 1889-1892 (2002)

[Publications] H Takeda, Seki Y, Nakamura S, Yamashita K: "Evaluation of Electrical Polarizability and in vitro Bioactivity of Apatite Sr_5(PO_4)_3OH Dense Ceramics"J Mater Chem. 151. 2490-2495 (2002)

[Publications] Yamashita K, Nakamura S, Kobayashi T: "Electrovector Ceramics for Biomedical Use : Manipulation of Bonelike Crystal Growth in SBF"Ceram. Eng. Sci. Proc. 23. 735-744 (2002)

[Publications] Nakamura S, Kobayashi T, Yamashita K: "Enhanced Osteoconductivity of Hydroxyapatite Ceramics Induced by Proton Transport Polarization Charges"Transport Eng. 6. 102-106 (2002)

[Publications] Nakamura M, Sekijima Y, Kobayashi T, Obata A, Nakamura: "Molecular Biologic Detections of Cell Activation Related Proteins on Bioniaterials"Proc. 2nd Asian Bioceram. 57-60 (2002)

[Publications] Obata A, Nakamura S, Yamashita K: "High Osteoconductive Surface for Bioactive Glass by Electrical Polarization"Bioceramics. 15. 441-444 (2002)

[Publications] Nakatnura S, Ueshima M, Kobayashi T, Yamashita K: "Crystal Growth Modification by Surface Charges on Ceramic Electret in Simulated Body Fluid"Bioceramics. 15. 445-448 (2002)

[Publications] Nakamura M, Sekijima Y, Kobayashi T, Nakamura s: "Molecular Biologic-Detections of Cell Activation Related Proteins on Polarized Hydroxyapatite, Biocermics"Bioceramics. 15. 643-646 (2002)

[Publications] 大柿真毅, 山下仁大: "PMMAにより傾斜機能化した新規ハイドロキシアパタイト複合材料の開発"東医歯大生材研報告. 36. 21-26 (2002)

[Publications] Nakamura S, Kobayashi T, Yamashita K: "Enhanced Osteoconductivity of Hydroxyapatite Ceramics Induced by Proton Transport Polarization Charges"Transport Eng. 6. 102-106 (2002)

大柿真毅東京医科歯科大学, 生体材料工学研究所, 助手 (50223748)