2004 Fiscal Year Final Research Report Summary
Selective Removal of Environmental Hormones by Biopolymer Conjugates
| Project/Area Number |
14350491
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
高分子構造・物性(含繊維)
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
NISHI Norio Hokkaido Univ., Grad.School of Environmental Earth Science, Prof., 大学院・地球環境科学研究科, 教授 (70001857)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAIRI Nobuo Hokkaido Univ., Grad.School of Environmental Earth Science, Prof., 大学院・地球環境科学研究科, 教授 (60153863)
NOMIZU Motoyoshi Tokyo Univ.of Pharmacy and Life Science, Faculty of Pharmaceutical Sciences, Prof., 薬学部, 教授 (00311522)
HARUKI Masahiro Hokkaido Univ., Grad.School of Environmental Earth Science, Asso.Prof., 大学院・地球環境科学研究科, 助教授 (40113609)
FURUIKE Tetsuya Hokkaido Univ., Grad.School of Environmental Earth Science, Inst., 大学院・地球環境科学研究科, 助手 (10360942)
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| Project Period (FY) |
2002 – 2004
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| Keywords | biopolvmer conjugate / environmental hormone / dialysis / dioxin / benzopyrene / cigarette filter / air cleaner / sol-gel method |
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| Research Abstract |
Selective removal of environmental hormones by some biorelated polymer conjugates, such as DNA and cyclodextrin-containing polymeric material was investigated. Cyclodextrin-containing materials bind selectively to bisphenol A and nonylphenol. DNA-containing materials bind to dioxin derivatives and benzopyrens, selectively and very effectively. Hence this project focused mainly on DNA materials.
DNA has unique chemical properties and is readily purified from salmon mitts and shellfish gonads. DNA has few commercial uses and is generally discarded as an industrial waste. We prepared water-insoluble and immobilized DNA-containing materials by UV-irradiation, dialysis method, sol-gel method and conjugation with synthetic polymer. The DNA-immobilized beads columns bound endocrine disruptors with a planar structure, such as dioxin-derivatives, polychlorobiphenyl (PCB)-derivatives, benzopyrene. Bisphenol A and diethylstilbestrol, which lack a planar structure, did not bind to the DNA-immobilized columns. These results suggest that DNA-immobilized bead columns could selectively remove chemical compounds with a planar structure by intercalation into the double-stranded DNA. DNA-immobilized beads have the potential to serve as useful biomaterials for environmental applications, such as filter of cigarette and air cleaner.
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Research Products
(8 results)
