2004 Fiscal Year Final Research Report Summary
Study on the mechanisms responsible for improvement of glucose, lipid, and amino acid metabolism.
| Project/Area Number |
14370022
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
SHIMOMURA Yoshiharu Nagoya Institute of Technology, Graduate School of Technology, Professor, 工学研究科, 教授 (30162738)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Taro Nagoya Institute of Technology, Graduate School of Technology, Associate Professor, 工学研究科, 助教授 (10252305)
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| Project Period (FY) |
2002 – 2004
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| Keywords | diabetes / insulin resistance / glucose metabolism / branched-chain amino acid metabolism / fatty acid metabolism / pyruvate dehydrogenase / branched-chain α-keto acid dehydroqenase / ラット |
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| Research Abstract |
The metabolism of glucose, fatty acids, and amino acids are dynamically interacted, and the interaction is very important in integration of the body system. The life-style-related diseases are getting common in Japan. It is evident that exercise is very effective to improve the life-style-related diseases, but the mechanisms are not so clear. In the present study, we have investigated the basic regulatory mechanisms of glucose, fatty acid, and amino acid metabolism in relation to exercise. We found that (1)greater PDK4 and less PDP1 in skeletal muscle of young/normal OLETF rats are responsible for the lowering of the PDC activity state and may be related with the development of diabetes mellitus, (2)promotion of fatty acid oxidation resulted in oxidation of branched-chain amino acids due to suppression of branched-chain α-keto acid dehydrogenase(BCKDH) kinase activity, (3)BCKDH kinase activity was regulated by estrogen, and (4)tumor-necrosis factor-a decreased the bound form of BCKDH kinase, resulting in activation of BCKDH complex and promotion of BCAA oxidation.
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Research Products
(11 results)
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[Journal Article] Activation of hepatic branched-chain α-keto acid dehydrogenase complex by tumor necrosis factor-α in rats.2005
Author(s)
Shiraki, M., Shimomura, Y., Miwa, Y., Fukushima, H., Murakami, T., Tamura, T., Tamura, N., Moriwaki, H.
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Journal Title
Biochem.Biophys.Res.Commun. 328
Pages: 973-978
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effects of liver failure on the enzymes in the branched-chain amino acid catabolic pathway.2004
Author(s)
Shimomura, Y., Honda, T., Goto, H., Nonami, T., Kurokawa, T., Nagasaki, M., Murakami, T.
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Journal Title
Biochem.Biophys.Res.Commun. 313
Pages: 381-385
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effects of liver failure on branched-chain α-keto acid dehydrogenase complex in rat liver and muscle : comparison between acute and chronic liver failure.2004
Author(s)
Honda, T., Fukuda, Y., Nakao, I., Katano, Y., Goto, H., Nagasaki, M., Sato, Y., Murakami, T., Shimomura, Y.
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Journal Title
J.Hepatol. 40
Pages: 439-445
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Downregulation of the skeletal muscle pyruvate dehydrogenase complex in the Otsuka Long-Evans Tokushima fatty rat both before and after the onset of diabetes mellitus.2004
Author(s)
Bajotto, G., Murakami, T., Nagasaki, M., Tamura, T., Tamura, N., Harris, R.A., Shimomura, Y., Sato, Y.
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Journal Title
Life Sci. 75
Pages: 2117-2130
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Regulation of branched-chain amino acid metabolism and pharmacological effects of branched-chain amino acids.2004
Author(s)
Shimomura, Y., Murakami, T., Nagasaki, M., Honda, T., Goto, H., Kotake, K., Kurokawa, T., Nonami, T.
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Journal Title
Hepatol.Res. 30S
Pages: 3-8
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms.2002
Author(s)
Kobayashi, R., Murakami, T., Obayashi, M., Nakai, N., Jaskiewicz, J., Fujiwara, Y., Shimomura, Y., Harris, R.A.
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Journal Title
Arch.Biochem.Biophys. 407
Pages: 231-240
Description
「研究成果報告書概要(欧文)」より
