2004 Fiscal Year Final Research Report Summary
Gene-Enviromental Interaction of Hypertension
| Project/Area Number |
14370226
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Ehime University |
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Principal Investigator |
HIGAKI Jitsuo Ehime University, School of medicine, Professor, 医学部, 教授 (70189744)
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| Co-Investigator(Kenkyū-buntansha) |
OKURA Takafumi Ehime University, School of medicine, Lecturer, 医学部, 講師 (40260385)
MIKI Tetsuro Ehime University, School of medicine, Professor, 医学部, 教授 (00174003)
OGIHARA Toshio Osaka University, Department of Geriatric medicine, Graduate School, Professor, 医学系研究科, 教授 (60107042)
RAKUGI Hiromi Osaka University, Graduate School, Associate Professor, 医学系研究科, 助教授 (20252679)
KATSUYA Tomohiro Osaka University, Graduate School, Lecturer, 医学系研究科, 講師 (30311757)
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| Project Period (FY) |
2002 – 2004
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| Keywords | genetic dissection / genetic epidemiology / hypertension / gene-environmental interaction / renin-angiotensin system / tailor-made medicine |
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| Research Abstract |
We investigated gene-enviromental interaction in hypertension and various cardiovascular diseases. By large scale genetic epidemiologic study, we showed that the genes of kinurein, acylCoA-synthase, angiotensinogen are associated with hypertension. Another new genes of chemoattractant factor 1, interferon 10, and angiotensin converting enzyme are showed as associating with bad prognosis of cardiomyopathy or longevity. Furthermore, we found that insulin resistance is an overall basis of pathophysiology of cardiovascular diseases. Insulin resistance contributes not only diabetes mellitus but also hypertension and cardiomyopathy. Genes and environmental factors of insulin resistance are now under, the investigation. These study will open the era of tailor-made medicine.
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[Journal Article] C-Reactive Protein Induces Apoptosis in Human Coronary Vascular Smooth Muscle Cells.2004
Author(s)
Blaschke F, Bruemmer D, Yin F, Takata Y, Wang W, Fishbein MC, Okura T, Higaki J, Graf K, Fleck E, Hsueh WA, Law RE.
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Journal Title
Circulation 110
Pages: 579-287
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Candesartan antihypertensive survival evaluation in Japan(CASE-J). Trial of cardiovascular events in high-risk hypertensive patients : Rationale, design, and methods.2003
Author(s)
Fukui T, Rahman M, Hayashi K, Takeda K, Higaki J, Sato T, Fukushima M, Sakamoto J, Morita S, Ogihara T, Fukiyama K, Fujishima M, Saruta T.
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Journal Title
Hypertension Research 26
Pages: 979-990
Description
「研究成果報告書概要(和文)」より
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[Journal Article] 「研究成果報告書概要(欧文)」より2003
Author(s)
Fukui T, Rahman M, Hayashi K, Takeda K, Higaki J, Sato T, Fukushima M, Sakamoto J, Morita S, Ogihara T, Fukiyama K, Fujishima M, Saruta T.
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Journal Title
Hypertension Research 26
Pages: 979-990
