2003 Fiscal Year Final Research Report Summary
Clinical feasibility of individually optimal chemotherapy based on the molecular targets in brain tumors
| Project/Area Number |
14370443
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MINEURA Katsuyoshi Kyoto Prefectural University of Medicine, Department of Neurosurgery, Professor, 医学研究科, 教授 (70134103)
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| Co-Investigator(Kenkyū-buntansha) |
TATSUZAWA Kazunori Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor, 医学研究科, 助手 (80347450)
OHWADA Kei Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor, 医学研究科, 助手 (80332948)
SASAJIMA Hiroyasu Kyoto Prefectural University of Medicine, Department of Neurosurgery, Assistant Professor, 医学研究科, 講師 (80196188)
TAKAHASHI Yoshinobu Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor, 医学研究科, 助手 (90347451)
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| Project Period (FY) |
2002 – 2003
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| Keywords | brain tumor / chemotherapy / chloroethylnitrosourea (CENU) / O^6-metylguanine-DNA methyltransferase (MGMT) / immunohistochemistry / chromosome analysis / ^<18>F-^<10>B-fluoroboronophenylalanine (FBPA) / pathognomonic diagnosis |
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| Research Abstract |
Immunohistochemical studies might provide superiority in better understanding the location and distribution of O^6-methylguanine-DNA methyltransferase (MGMT) activity. Brain tumors are heterogeneous in histological structure and biological properties. MGMT activity varies widely among brain tumors and even within individual tumor tissue. MGMT activity, especially when judged from biopsied specimens, may easily underestimate the degree of the activity. Best confirmation requires a large amount of tumor tissue containing the most active parts of a tumor.
Determinations of genetic alternation are useful and loss of 1p and/or 19q is a landmark of drug sensitivity. Oligodendrogliomas having combined loss of 1p and 19q significantly prolong survival. Thus, chemotherapy regimen should be selected and applied on according to individual tumors based on biological and molecular characteristics.
There is a critical disadvantage in obtaining biological information on the entire brain tumors because
… More
the resected amounts of tumor tissue are often limited. Since positron emission tomography (PET) can image the entire tumor, it therefore overcomes such problems with histologic evaluation alone. In the present study, we obtained in vivo evidence of boron-derivatives in gliomas prior to treatment. ^<18>F-^<10>B-Fluoroboronophenylalanine (FBPA) is accepted as an indicator of the amino acid transport process through blood-brain barrier and in the tumor cells. FBPA-PET method was accurate for the measurements of FBPA incorporation in gliomas ; even the histologic diagnosis was insufficient because of the small amounts of tissue available from biopsy. FBPA-PET is practical and clinically useful for predicting prognosis and for determining whether tumors will be sensitive or resistant boron neutron capture therapy in gliomas.
Accumulation of knowledge of genetic alternations and in vivo crucial biological properties will establish the individual optimum treatments including chemotherapy in brain tumors. Less
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Research Products
(17 results)
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[Publications] Yamada K, Kizu O, Mori S, Ito H, Nakamura H, Yuen S, Kubota T, Tanaka O, Akada W, Sasajima H, Mineura K, Nishimura T: "Brain fiber tracking with clinically feasible diffusion-tensor MR imaging. Initial experience."Radiology. 227. 295-301 (2003)
Description
「研究成果報告書概要(欧文)」より
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