2003 Fiscal Year Final Research Report Summary
Analysis of changes in body temperature rhythm during fasting
| Project/Area Number |
14570058
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
|---|
| Research Institution | OSAKA UNIVERSITY |
|---|
Principal Investigator |
NAGASHIMA Kei Osaka University, School of Medicine, Assistant Prof., 医学系研究科, 助手 (40275194)
|
|---|
| Project Period (FY) |
2002 – 2003
|
| Keywords | body temperature / metabolism / circadian rhythm / Vagus nerve / SCN / heat loss / homeostasis / food deprivation |
|---|
| Research Abstract |
It is well known that body temperature (T_b) follows a circadian rhythm. Despite recent advance in knowledge of thermoregulation, we know only a little about the mechanism of the T_b rhythm. In this symposium, we show several evidences proving that i) the prime mechanism for the circadian T_b rhythm is a change in characteristics of thermoregulatory processes according to circadian phases, ii) clock genes and the suprachiasmatic nucleus are involved in the mechanism.
T_b rhythm during fasting. In ad-lib feeding rats, T_b rhythm was linked with heat production rhythm. Moreover, tail surface temperature reflecting active heat loss also changed linearly with the T_b rhythm. Thus it is thought that heat production dominantly determines the T_b rhythm in fed condition. Although heat production decreased and its circadian amplitude was blunted during 3-day fasting, the T_b rhythm was well maintained. Moreover, the tail temperature decreased greatly in the active phase. These results suggest that animals control their circadian T_b rhythm by modulating thermoregulatory responses, which depends on feeding and/or nutritional states.
|
Research Products
(6 results)
-
-
-
-
-
[Publications] Nagashima, K., Nakai, S., Matsue, K., Konishi, M., Tanaka, M., Kanosue, K.: "Effects of fasting on thermoregulation processes and the daily oscillations in rats."American Journal of Physiology. 284. R1486-R1493 (2003)
Description
「研究成果報告書概要(欧文)」より
-
