Association of retinal antigen Brn 3b with pathogenesis of Behcet's disease

2003 Fiscal Year Final Research Report Summary

• Project/Area Number: 14570241
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bacteriology (including Mycology)
• Research Institution: Sapporo Medical University
• Principal Investigator: ISOGAI Hiroshi Sapporo Medical University, School of Medicine, Associated Professor, 医学部, 助教授 (50137436)
• Project Period (FY): 2002 – 2003
• Keywords: Brn 3b / Behcet' disease / 網膜

Research Abstract

About 1kb of Brn 3b DNA was obtained PCR from cDNA library of human embryonic brain. The product was inserted into Escherichia coli and the bacteria produced Brn 3b protein. The bacteria strain was agglutinated by anti-serum to synthetic peptide of Brn 3b. Furthermore, several sera from the patients with BD agglutinated this strain. The results suggested that the Brn 3b protein was correlated with the Behcet's disease.
Now, it is the final stage for developing TG mice which were inserted this DNA.

Research Products

• [Journal Article] Role of Streptococcus sanguis and traumatic factors in Behcet's disease (2003)
  • Author(s): Isogai E, Isogai H, Kotake S, Ohno S, Kimura K, Oguma K.
  • Journal Title: J Appl Res 3(4) Pages: 64-75
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Antimicrobial activity of synthetic human CAP18 peptides to Streptococcus sanguis isolated from pateints with Beheet's disease. (2003)
  • Author(s): Isogai E, Hirata M, Isogai H., Matuse K., Kimura K, Yokota K, Oguma K, Tojo M, Kaneko F, Kotake S, Ohno S.
  • Journal Title: In : Adamantiades-Behcet's disease (Ed : C.C.Zouboulis), Advances in Experimental Medicine and Biology, Vol 528, (Kluwer Academic/Pleunum Publishers, New York) 523 Pages: 195-200
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of Streptococcus sanguis and traumatic factors in Behcet's disease (2003)
  • Author(s): Isogai E, Isogai H, Kotake S, Ohno S, Kimura K, Oguma K
  • Journal Title: J Appl Res 3(4) Pages: 64-75
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antimicrobial activity of synthetic human CAP 18 peptides to Streptococcus sanguis isolated from pateints with Behcet's disease. In : Adam antiades -Behcet's disease (Ed : C.C.Zouboulis) (2003)
  • Author(s): Isogai E, Hirata M, Isogai H., Matuso K., Kimura K, Yokota K, Oguma K, Tojo M, Kaneko F, Kotake S, Ohno S
  • Journal Title: Advances in Experimental Medicine and Biology(Kluwer Academic/Pleunum Publishers, New York) Vol 528 Pages: 195-200
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antibody cross reactivity from sera of patients with Behcet's disease with synthetic peptides that have homologies with protein from Streptococcus sanguis. (2002)
  • Author(s): Isogai E, Isogai H, Kotake S, Ohno S, I shihara M, Aoki K, Tojc M, Kaneko F, Yokota K, Oguma K
  • Journal Title: J.Appl.Res. 2(3) Pages: 185-191
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Antibody cross reactivity from sera of patients with Behcet's disease with synthetic peptides that have homologies with protein from Streptococcus sanguis. (2002)
  • Author(s): Isogai E, Isogai H, Kotake S, Ohno S, Ishihara M, Aoki K, Tojo M, Kaneko F, Yokota K, Oguma K
  • Journal Title: J.Appl.Res. 2(3) Pages: 185-191
  • Description: 「研究成果報告書概要(欧文)」より