2003 Fiscal Year Final Research Report Summary
IL-12-mediated regulation of human chemokine receptor function
| Project/Area Number |
14570405
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内科学一般
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAWASAKI Hiroshi The University of Tokyo, Institute of Medical Science, Research Assistant, 医科学研究所, 助手 (80280957)
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| Project Period (FY) |
2002 – 2003
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| Keywords | cytokine / chemokine / dendritic cell / signal transduction / antigen presentation / allergy / infalmmation / autoimmunity |
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| Research Abstract |
To clarify the mechanism of the initiation of an Ag-specific immune response in epidermis in the human system, we examined the role of the interplay between dendritic cells (DCs) and Langerhans cells (LCs) in vitro. DCs exhibited more potent expressions of the MHC product and costimulatory molecules than LCs. LCs were less effective for the internalization of exogenous Ag, and the activation of allogeneic and autologous Ag-specific T cells than DCs. DCs and LCs expressed different in chemokine receptor repertoire and responsiveness. LCs can transfer unprocessed Ag to DCs via cell to cell contact, and these trans-Ag-loaded DCs induced an Ag-specific T cell response
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Research Products
(13 results)
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[Book] 腎炎2004
Author(s)
谷口茂夫 (分担執筆)
Total Pages
140
Publisher
文光堂
Description
「研究成果報告書概要(和文)」より
