2003 Fiscal Year Final Research Report Summary
Role of molecular chaperon in gastric mucosal injury and restoration
| Project/Area Number |
14570442
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Akita University |
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Principal Investigator |
OTAKA Michiro Akita University, School of Medicine, Assistant Professor, 医学部, 講師 (30250872)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Sumio Akita University, School of Medicine, Professor, 医学部, 教授 (20138225)
ITOH Hideaki Akita University, Faculty of Engineering and Resource Science, Professor, 工学資源学部, 教授 (80168369)
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| Project Period (FY) |
2002 – 2003
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| Keywords | molecular chaperon / gastric mucosal protection / gastric mucosal restoration / stress / gastric ulcer / gastric mucosal lesion / heat shock protein |
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| Research Abstract |
Many recent studies have indicated the importance of heat shock (proteins (HSPs) for survival of cells under stress conditions. Some HSPs are known to be involved in cytoprotection against environmental stresses mediated by their function as a "molecular chaperon". We have reported that a 72-kDa heat shock protein (HSP72, stress-inducible HSP7O) plays essential role in the gastric and colonic mucosa in vivo.
In the present study demonstrated that
1)When gastric mucosal HSP72 is induced by zinc derivatives, protective ability and wound restoration are enhanced in vitro and in vivo.
2)Over-expression of HSP72 by gene-transfection clearly enhanced cytoprotective ability against ethanol-induced cell damage and wound restoration in cultured gastric mucosal cells.
Our results suggested that expression of HSP72 could play important roles not only in cytoprotection but also in mucosal wound restoration mediated by the function as a molecular chaperon of HSP72.
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Research Products
(18 results)
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[Publications] Odashima, M., Otaka, M., Jin, M., Konishi, N., Sato, T., Kato, S., Matsuhashi, T., Nakamura, C., Watanabe, S.: "Induction of a 72-kDa Heat Shock Protein in Cultured Rat Gastric Mucosal Cells and Rat Gastric Mucosa by Zinc L-Carnosine."Dig Dis Sci. 47. 2799-2804 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Matsuumori, M., Itoh, H., Toyoshima, I., Komatsuda, A., Sawada, K., Fukuda, J., Tanaka, T., Okubo, A., Kiouchi, H., Mizoi, K., Suzuki, A., Kamada, F., Otaka, M., Shoji, Y., Takada, G.: "Characterization of the 105-kDa molecular chaperone."Eur J Biochem. 269. 5632-5641 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Itoh, H., Komatsu, A., Ohtani, H., Wakui, H., Imai, H., Sawada, K., Otaka, M., Ogura, M., Suzuki, A., Hamada, F.: "Mammalian HSP60 is quickly sorted into the mitochondria under condition of dehydration."Eur J Biochem. 269. 5931-5938 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Miyazaki T, Sagawa R, Honma T, Noguchi S, Harada T, Komatsuda A, Ohtani H, Wakui H, Sawada KI, Otaka M, Watanabe S, Jikei M, Ogawa N, Hamada F, Itoh H.: "73-kDa Molecular Chaperone HSP73 Is a Direct Target of Antibiotic Gentamicin."J Biol Chem. 279. 17295-17300 (2004)
Description
「研究成果報告書概要(和文)」より
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[Publications] Itoh S, Otaka M, Odashima M, Zeniya A, Okuyama A, Jin M, Otani S, Iwabuchi A, Sasahara H, Masamune O, Watanabe S.: "Inhibition of CN(protein phosphatase-2B) suppresses Ca2+-mediated acid secretion in rtas."Aliment Pharmacol Ther. 16. S26-S28 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Odashima, M., Otaka, M., Jin, M., Konishi, N., Sato, T., Kato, S., Matsuhashi, T., Nakamura, C., Watanabe, S.: "Induction of a 72-kDa Heat Shock Protein in Cultured Rat Gastric Mucosal Cells and Rat Gastric Mucosa by Zinc L-Carnosine."Dig Dis Sci. 47. 2799-2804 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Matsumori, M., Itoh, H., Toyoshima, I., Komatsuda, A., Sawada, K., Fukuda, J., Tanaka, T., Okubo, A., Kiouchi, H., Mizoi, K., Suzuki, A., Kamada, F., Otaka, M3, Shoji, Y., Takada, G.: "Characterization of the 105-kDa molecular chaperone."Eur J Biochem. 269. 5632-5641 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Itoh, H., Komatsu, A., Ohtani, H., Wakui, H., Imai, H., Sawada, K., Otaka, M., Ogura.M., Suzuki, A., Hamada, F.: "Mammalian HSP60 is quickly sorted into the mitochondria under condition of dehydration."Eur J Biochem. 269. 5931-5938 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Miyazaki T, Sagawa R, Honma T, Noguchi S, Harada T, Komatsuda A, Ohtani H, Wakui H, Sawada KI, Otaka M, Watanabe S, Jikei M, Ogawa N, Hamada F, Itoh H.: "73-kDa Molecular Chaperone HSP73 Is a Direct Target of Antibiotic Gentamicin."J Biol Chem. 279. 17295-17300 (2004)
Description
「研究成果報告書概要(欧文)」より
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