2003 Fiscal Year Final Research Report Summary
Comprehensive studies on chronic infection with Chlamydia pneumoniae as a risk factor for atherosclerosis
| Project/Area Number |
14570668
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | EHIME UNIVERSITY |
|---|
Principal Investigator |
KOHARA Katsuhiko Ehime University, School of Medicine, Associate professor, 医学部, 助教授 (30260384)
|
|---|
| Project Period (FY) |
2002 – 2003
|
| Keywords | Chlamydia pneumoniae / chronic infection / seropositivity / adhesion molecule / chemokine / oxidative stress / susceptible gene / angiotensinogen |
|---|
| Research Abstract |
Chronic and persistent infection a risk factor for atherosclerosis has been the focus of research. In particular, Chlamydia pneumoniae(Cp), has attracted so much attention that several clinical trials using antimicrobial drugs have been carried out. Although infection and activation of vascular endothelium by micropathogen is one of main underlying mechanisms, the mechanisms how the infection turns out to persist in certain patients after pulmonary airways infections remains to be determined. Three major results were obtained in the present study : (1)Cp seropositivity showed a significant positive associations with soluble adhesion molecules, ICAM-1 and VCAM-1,as well as chemokines MCP1 concentration, (2)Cp seroposivity significantly associated with systemic oxidative stress expressed with urinary concentration of 8-epi PGF2 alfa, and (3)Cp seropositivity was significantly associated with M235T angiotensinogen gene polymorphisms. These findings provide useful information for the comprehensive understanding about the mechanisms linking Cp infection and atherosclerosis.
|
Research Products
(12 results)
