2003 Fiscal Year Final Research Report Summary
Effect of DHEA(S) on the progression of life style related disease : epidemiological and basic analysis.
| Project/Area Number |
14571061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Gifu University |
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Principal Investigator |
YAMAMOTO Mayumi Gifu University Hosp., 3rd Dept. of Int. Med., Lectureler, 医学部附属病院, 講師 (40313879)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIZAWA Masayoshi Gifu University Hosp., 3rd Dept. of Int. Med., Lectureler, 医学部附属病院, 講師 (20313893)
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| Project Period (FY) |
2002 – 2003
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| Keywords | DHEA / insulin / insulin resisitance / PPAR / fat / breast cancer / obesity |
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| Research Abstract |
We investigated effects of DHEA(S) on the progression of life style-related diseases.
DHEA and insulin resistance : DHEA activated P13-kinase and atypical PKC in rat adipocytes. Since these activation induced glucose uptake, DHEA may improve insurin resistance in the insulin target organs.
DHEA and obesity : DHEA decreased the expression levels of PPAR and triglyceride volume through the suppression of mRNA levels in adipocyte lipid-binding protein and sterol regulatory element-binding protein. DHEA might have an important roles in function of adipocytes.
DHEA and breast cancer : DHEA increased the human breast cancer cell proliferation as a mitogen, which was diminished with 4-hydroxyandrostendione inhibiting aromatase enzyme.
DHEA administration might have an advantage to prevent some of life style-related diseases like obesity and diabetes mellitus.
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Research Products
(12 results)
