• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2003 Fiscal Year Final Research Report Summary

Plasma levels of ghrelin in anorexia nervosa patients

Research Project

Project/Area Number 14571076
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionNational Graduate Institute for Policy Studies

Principal Investigator

SUZUKI Mari  National Graduate Institute for Policy Studies, Health Services Center, Professor, 保健管理センター, 教授 (90128140)

Project Period (FY) 2002 – 2003
KeywordsGhrelin / Aniorexia nervosa / Degradation
Research Abstract

Octanoylated ghrelin (1-28) (intact ghrelin) is rapidly degraded to desoctanoyl forms or smaller fragments (degraded ghrelin). Plasma levels of intact and degraded ghrelin were examined in 30 anorexia nervosa patients (AN) (body mass index (BMI) : 8.81-22.4 kg/m^2) and 16 age-matched healthy women using several assay methods. Plasma ghrelin levels measured by immunocomplex transfer-enzyme immunoassay (ICE-EIA) detecting specifically intact ghrelin in AN were lower than those of controls. Plasma ghrelin levels in AN by Active Ghrelin ELISA Kit advertised as specifically detecting intact ghrelin were not significantly different from controls. Levels of desoctanoyl ghrelin by Desacyl-Ghrelin ELISA, N-terminus ghrelin by Ghrelin Active RIA, and C-terminus ghrelin by Ghrelin Total RIA were significantly higher in AN than in controls, and displayed significant negative correlations with BMI.
Plasma levels of intact ghrelin in AN vary from lower than to similar to those of controls. Degraded forms of ghrelin are elevated in AN.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Mari Hotta et al.: "Plasma levels of intact and degraded ghrelin and responses to glucose infusion"J Clin Endocrinol Metab. in press. (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mari Hotta et al.: "Plasma levels of intact and degraded ghrelin and responses to glucose infusion in anorexia nervosa"J Clin Endocrinol Metab. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2005-04-19   Modified: 2021-12-17  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi