| Research Abstract |
Some of the obese Japanese do not respond well to the treatment that consists of diet and exercise therapy. The main reason is that in these obese adults who have so-called "thrifty gene", the resting metabolic rate (RMR) is being decreased. For example, obese patients with the polymorphism (Trp64Arg) of the β3-adrenergic receptors (β3-AR) has the reduction of RMR by 200 kcal/day, and are required further reduction of the calories that correspond to this 200 kcal from the ordinary low calory diet. The polymorphism on the uncoupling protein 1 (A-3826G), in whom RMR is decreased by 100 kcal. For the obesity in individuals when both the polymorphisms are combined, in total 300 kcal should be lowered from the ordinary low calory diet. However, in the subjects with polymorphism of the β2-AR (Arg16Gly), RMIR is elevated by 100-300 kcal/day. These are the reasons that the introduction of genetic diagnosis is also expected in planning the diet therapy to individual obese patients. In the present study, we newly checked further 26 kinds of the polymorphisms of obesity related genes in obese patients and found next results. That is : the polymorphism (Ala54Thr) of FABP2 gene (RMR : reduction of 100 kcal/day), the polymorphism (Met235Thr) of Angiotensinogen gene (RMIR : reduction of 200 kcal/day), the polymorphism (G1704T) of AGE gene (RMR : reduction of 350 kcal/day), the polymorphism (Pro12Ala) of PPAR-γ2 gene (RMR : reduction of 150 kcal/day), the polymorphism (Glu23Lys) of Kir6.2 gene (RMIR : increasing of 100 kcal/day) and the polymorphism (Arg1273Arg) of SUR1 gene (RMR : increasing of 300 kcal/day). Therefore, we are now investigating whether the combination of these 9 gene polymorphisms is effective for Tailor-made diet therapy in obese patients.
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