2003 Fiscal Year Final Research Report Summary
Study of the New Therapeutic Strategy for the Malignant Brain Tumor by using of Artificially Designed Pore-Forming Small Globular Protein
| Project/Area Number |
14571348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Fukuoka University |
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Principal Investigator |
IWASA Mitsutoshi Fukuoka University, School of Medicine, Assistant, 医学部, 助手 (40341416)
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| Co-Investigator(Kenkyū-buntansha) |
TSUGU Hitoshi Fukuoka University, School of Medicine, Lecturer, 医学部, 講師 (80279273)
LEE Sannamu Fukuoka University, Faculty of Science, Assistant, 理学部, 助手 (40248472)
FUKUSHIMA Takeo Fukuoka University, School of Medicine, Professor, 医学部, 教授 (10078735)
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| Project Period (FY) |
2002 – 2003
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| Keywords | SGP / U87-MG / cytotoxic / apoptosis / necrosis / pore-forming / lipid bilayer |
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| Research Abstract |
Artificially designed pore-forming small globular protein (SGP) has membrane-disrupting properties and anti-tumor activity We applied this protein to malignant brain tumor. The study shows that not only diminishing tumor volume but also tumor curing without recurrence. We compared SGP with CDDP (Cisplatin) which is therapeutically used for malignant brain tumor. But CDDP couldn't extinguish tumor lesion.
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