Repair and replace the degenerative or defective cartilage using tissue engineering

2004 Fiscal Year Final Research Report Summary

• Project/Area Number: 14571397
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Osaka City University
• Principal Investigator: KITANO Toshio Osaka City University, Graduate School of Medicine, Lecture, 大学院医学研究科, 講師 (50291597)
• Co-Investigator(Kenkyū-buntansha): KAWASE Tokuzo Kyoto Institute of Technology, Division of Chemistry and Materials Technology, Professor, 工芸学部物質工学科, 教授 (60152956) ; TAKAOKA Kunio Osaka City University, Graduate School of Medicine, Professor, 大学院医学研究科, 教授 (30112048)
• Project Period (FY): 2002 – 2004
• Keywords: Repair of cartilage / Lubrication / Arthorplasty / DDS

Research Abstract

Hyaluronic acid and/or Chondroitin sulfate capsulated in Lα-DPPC (dipalmitoylphosphatidylcholine) liposome could accelerate the repair of degenerative and/or defective articular cartilage. Using this Lα-DPPC drug delivery system (DDS), we investigate the lubrication between the disk shaped specimens from porcine knee joint. These results showed that Hyaluronic acid encapsulated in the cationic liposome for the lubricant decreased the coefficient of friction between cartilage specimens at low angular velocity. At low angular velocity, boundary lubrication mechanism is dominant, especially in the degenerative and/or defective articular. For the purpose of accelerating the repair of degenerative and/or defective articular cartilage, it is important to keep low friction on articulate cartilage surfaces during cartilage repair. This research result suggested the possibility of new treatment system of the arthorplasty, i.e., repairing the degenerative and/or defective articular cartilage using 1) the endoscopic surgery and 2) the incubation of the cartilage on site 3) without using artificial scaffold nor culture dish. This research develops the following research project (Project number : 18591672, Drug delivery system to improve the joint lubrication and to accelerate the regeneration of joint cartilage.