2003 Fiscal Year Final Research Report Summary
Properties of the masticatory muscle piimary afferents from the trigeminal ganglion in the rats
| Project/Area Number |
14571731
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | OSAKA UNIVERSITY |
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Principal Investigator |
MORITANI Masayuki OSAKA UNIV., GRALDUATE SCHOOL OF DENTISTRY, ASSISTANT PROFESSOR, 大学院・歯学研究科, 講師 (80303981)
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| Co-Investigator(Kenkyū-buntansha) |
ATSUSHI Ypshida OSAKA UNIV., GRALDUATE SCHOOL OF DENTISTRY, PROFESSOR, 大学院・歯学研究科, 教授 (90201855)
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| Project Period (FY) |
2002 – 2003
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| Keywords | trigeminal nerve / masticatory muscle / sensory / primary afferent nueron / trigeminal ganglion / pain / neuron tracer / neuro-transmitter |
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| Research Abstract |
The main findings of this research project are as follows:
(1) Rerogradely labeled muscle afferent neurons were significantly lager and fewer than retrogradely labeled cutaneous afferent neurons. (2) α-D-galactose specific lectin IB4 binding was found in 6% of muscle and 44% of cutaneous afferents indicating a target specific difference. (3) The experiments inducing muscle inflammation by injecting complete Freund's adjuvant (CFA) to masseter muscle indicate that the percentage of trigeminal ganglion muscle afferent neurons immunoreactive for CGRP or SP does not change significantly four days after inflammation. (4) Muscle inflammation resulted in increased number of CGRP and substance P positive trigeminal ganglion muscle afferent neurons 12 days after CFA injection. It is suggested that the increased number of peptidergic neurons following muscle inflammation is recruited equally from trigeminal group III and IV muscle afferents. (5) It is indicated that in trigeminal ganglia, P2X3 receptor is not exclusively expressed in IB4 neurons but includes larger neurons. Target specific differences exist in P2X3 and IB4 expression. Furthermore, it is suggested that deep tissue inflammation can modulate the number of neurons expressing the P2X3 receptor.
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Research Products
(9 results)
