2003 Fiscal Year Final Research Report Summary
Molecular biology of calus formation after mandibular reconstruction using vasculized long bone
| Project/Area Number |
14571887
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kobe University |
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Principal Investigator |
YOKOO Satoshi Kobe University, Graduate School of Medicine, Lecturer, 医学部附属病院, 講師 (00322206)
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| Co-Investigator(Kenkyū-buntansha) |
TERASHI Hiroto Kobe University, Graduate School of Medicine, Associate Professor, 医学部附属病院, 助教授 (80217421)
WATATANI Sanae Kobe University, Graduate School of Medicine, Assistant Professor, 医学部附属病院, 助手 (50343265)
KOMORI Takahide Kobe University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (50251294)
OJIMA Yasutaka Kobe University, Graduate School of Medicine, Attending researcher, 医学部附属病院, 医員
UMEDA Masahiro Kobe University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (60301280)
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| Project Period (FY) |
2002 – 2003
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| Keywords | vascularized bone transplantation / long bone / menbranous bone / calus / immunohistochemistry / rat |
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| Research Abstract |
A new mandibular reconstruction model using the saphenous artery osteocutaneous flap is developed in the rat. The saphenous artery osteocutaneous flap in the rat was reported by Mutaf, et al in the Journal of Plastic and Reconstructive Surgery, 1994. This is a true osteocutaneous flap flap composed of a skin island from the medial aspect of the lower leg, the the gracilis and semitendinosus muscles, and a bone segment from the tibia based on the saphenous vascular pedicle. The mandibular defect was reconstructed by the vascularized tibia harvested in these technigue.
The process of membranous bone healing has not been clearly understood. The union of fibrous bone was assumed to be the only process in the healing of membranous bones. In the present study, cartilage formation associated with the bone healing process was observed. These findings are similar to early stage of endochondral (long) bone healing. It is concluded that cartilage tissue is formed in the process of membranous bone defect healing. In comparison with the long bone defect healing process, however, callus formation was limited.
We conclude that membranous bone periosteum is not main factor in the repair of bone defects, and that bone formation from membranous periosteum dose not itself completely heal the bone defect. The present observations indicated that the main sources of bone formation are the endosteum and bone marrow. We are of the union their investigation reveals the healing process of membranous bone defects to differ from that of endochondral ossification.
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Research Products
(12 results)
