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2003 Fiscal Year Final Research Report Summary

Intervention of interleukin to neuropathic pain

Research Project

Project/Area Number 14571905
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKyushu Dental College

Principal Investigator

SHIIBA Shunji  Kyushu Dental College, Associate professor, 歯学部, 助手 (20285472)

Co-Investigator(Kenkyū-buntansha) SAKAMOTO Eiji  Kyushu Dental College, Associate professor, 歯学部, 助手 (00295859)
NAKANISHI Osamu  Kyushu Dental College, Professor, 歯学部, 教授 (50137345)
Project Period (FY) 2002 – 2003
KeywordsNeuropathic pain / Interleukin-6 / Inflammatory cytocaine / CCI / Dorsal Root Gangrion / Sciatic nerve / Neuritis / 疼痛関連行動
Research Abstract

It was clear that painful animal model, CFA(complete Freund's adjuvant) and CCI(choronic constriction injury) in sciatic nerve induced neuropathic pain. The pain-related behavior which these models lick hindpow and take escape behavior for heat radiation and a pin prick test. That these pain-related action is inhibited by administration of thalidomide of immunomodulator and cyclosporine S of an immunosuppressive drug, and a substance of inflammatory contributes to neuropathic pain is predicted. Therefore I paid attention to interleukin-6(IL-6) which contributed to neurotization deeply. I understood that a pain-related behavior for all algetic irritation was inhibited when I preloaded an antibody of IL-6. IL-6 developed in rat dorsal root ganglia, spinal dorsal root and nerve injury region from the immediately after which nerve damage caused. I became a peak after nerve damage in three days and continued it to 14 after a disorder. This immunostaining result accords with course of rat pain-related behavioral degree. Rat sciatic nerve exposed was soaked into IL-6 solution, and it developed a pain-related behavior as CCI and CFA painful model. Intervention of IL-6 to neuropathic pain became clear. Early administration of an IL-6 blocker after nerve injury is effective as a therapy of neuropathic pain.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 椎葉俊司, 今村佳樹, 仲西 修: "筋に由来する痛み"九州歯科学会雑誌. 57巻. 1-7 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 今村佳樹, 椎葉俊司, 坂本英治, 仲西 修: "歯科治療に関連した難治性疼痛"日本歯科麻酔学会雑誌. 32巻. 180-181 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shunji Shiiba, Imamura Yoshiki Nakanishi Osamu: "Myofascial pain -Muscle problem that can present as toothache"Journal of Kyushu Dental College. 57(1-2). 1-7 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Imamura Yoshiki, Shunji Shiiba, Eiji sakamoto, Nakanishi Osamu: "Myofascial pain-Muscle problem that can present as toothace"Journal of Japanese dental Anesthesiology. 32(2). 180-181 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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