2003 Fiscal Year Final Research Report Summary
Application of the three-dimensional jaw tracking system to mice and investigation of the jaw function using genetically engineered mouse.
| Project/Area Number |
14571956
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
矯正・小児・社会系歯学
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| Research Institution | Nagasaki University |
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Principal Investigator |
KOGA Yoshiyuki Nagasaki University, Hospital of Medicine and Dentistry, Lecturer, 医学部・歯学部附属病院, 講師 (50175329)
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| Co-Investigator(Kenkyū-buntansha) |
IIJIMA Seiko Nagasaki University, Graduate School of Biomedical Sciences, Assistant Professor, 大学院・医歯薬学総合研究科, 助手 (00202812)
NAKAO Noriko Nagasaki University, Graduate School of Biomedical Sciences, Assistant Professor, 大学院・医歯薬学総合研究科, 助手 (20333578)
YOSHIDA Noriaki Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (40230750)
YAMADA Yoshiaki Nagasaki University, School of Dentistry, Professor, 歯学部, 教授 (80115089)
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| Project Period (FY) |
2002 – 2003
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| Keywords | Magnetic sensor / Hall element / Mandibular tracking / Freely movina mouse / EMG / BDNF-lackina mouse |
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| Research Abstract |
・Collection of basic data of mouse jaw function (three-dimensional jaw movements and EMG).
The three-dimensional jaw-tracking system was implanted in the normal mice. The jaw movement trajectories were recorded with foods in different texture : There were characteristic jaw movement patterns during mastication. The EMG recording were added to the system in order to investigate the mouse jaw function more in detail. Thus, jaw movement trajectories and masticatory muscle activities could be recorded simultaneously.
・Evaluation of the acquisition of jaw function.
To evaluate the acquisition of mouse's normal jaw function, the mice were divided into two groups. One group bred with solid food, and another group bred with liquid food. The jaw movement range of the liquid food group was smaller than that of the hard hood group and the characteristic EMG activity was found in the liquid food group.
・Masticatory jaw movements and muscle activities of BDNF lacking mouse
The chewing pattern in BDNF lacking mice was more irregular and smaller than that of wild mice. During hard food chewing, the lateral jaw movement of BDNF lacking mice was restrict and the vertical jaw movement was increased.
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