2004 Fiscal Year Final Research Report Summary
Solid Phase Synthesis in Water-Development of Green Chemistry
| Project/Area Number |
14572024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
KAWASAKI Koichi Kobe Gakuin University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (40068242)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Mitsuko Kobe Gakuin University, Faculty of Pharmaceutical Sciences, Senior Assistant, 薬学部, 助手 (90131531)
HOJO Keiko Kobe Gakuin University, Faculty of Pharmaceutical Sciences, Research Assistant, 薬学部, 実験助手 (20289028)
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| Project Period (FY) |
2002 – 2004
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| Keywords | solid phase synthesis / peptide synthesis / green chemistry / Leu-enkephalin / water-soluble protecting group / water |
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| Research Abstract |
Solid phase peptide synthesis (SPPS) is a well-established technique for the facile and rapid preparation of peptides, but it requires large amounts of organic solvents. Since the safe disposal of organic solvents is an important environmental issue, the ability to synthesize peptides in an aqueous medium would be preferable. In order to do so, water-soluble N-protected amino acids are necessary. We have successfully used the water-soluble N-protecting groups, 2-[phenyl(methyl)sulfonio]ethoxycarbonyl (Pms), ethanesulfonylethoxycarbonyl (Esc) and 2-(4-sulfophenylsulfonyl)ethoxycarbonyl (Sps), for the SPPS of Leu-enkephalin amide in water.
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[Journal Article] Application of ethanesulfonylethoxycarbonyl (Esc) group for solid phase synthesis in water.2005
Author(s)
Hojo, K., Kita, E., Yamamoto, S., Yamaguchi, F., Maeda, M., Kawasaki, K.
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Journal Title
Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries 2004 (Edited by Epton, R.)(Mayflower Wordwide Limited, London, England, UK)
Pages: 237-240
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Peptide synthesis in water IV. preparation of N-ethanesulfonylethoxy-carbonyl(Esc) amino acids and their application to solid phase peptide synthesis2004
Author(s)
Hojo, K., Maeda, M., Smith, T.J., Kita, E., Yamaguchi, F., Yamamoto, F., Kawasaki, K.
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Journal Title
Chem.Pharm.Bull. 52
Pages: 422-427
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Peptide synthesis in water IV. preparation of N-ethanesulfonylethoxy- carbonyl (Esc) amino acids and their application to solid phase peptide synthesis2004
Author(s)
Hojo, K., Maeda, M., Smith T.J., Kita, E., Yamaguchi, F., Yamamoto, F., Kawasaki, K.
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Journal Title
Chem.Pharm.Bull. 52
Pages: 422-427
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Solid phase synthesis in water : application of the ethansulfonylethoxycarbonyl (Esc) group.2004
Author(s)
Hojo, K., Kita, E., Yamamoto, S., Yamaguchi, F., Maeda, M., Kawasaki, K.
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Journal Title
Peptide Science 2003 (Edited by Ueki, M.)(PROTEIN RESEARCH FOUNDATION, Minoh-shi, Japan)
Pages: 145-146
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A New Reagent, 2-[Phenyl(methyl)sulfonio]ethyl-4-nitro- phenylcarbonate Tetrafluoroborate (Pms-ONp), for Preparing Water-Soluble N-Protected Amino Acids2003
Author(s)
Hojo, K., Maeda, M., Takahara, Y, Yamamoto, S., Kawasaki, K.
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Journal Title
Tetrahedron Lett. 44
Pages: 2849-2851
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A New Reagent, 2-[Phenyl(methyl)sulfonio]ethyl-4-nitro-phenylcarbonate Tetrafluoroborate (Pms-ONp), for Prepareing Water-Soluble N-Protected Amino Acids.2003
Author(s)
Hojo, K., Maeda, M., Kawasaki, K.
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Journal Title
Peptide Science 2002 (Edited by Yamada, T.)(PROTEIN RESEARCH FOUNDATION, Minoh-shi, Japan)
Pages: 153-154
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A New Reagent, 2-[Phenyl(methyl)sulfonio]ethyl-4-nitro-phenylcarbonate Tetrafluoroborate(Pms-ONp), for Preparing Water-Soluble N-Protected Amino Acids2002
Author(s)
Hojo, K., Maeda, M., Takahara, Y., Yamamoto, S., Kawasaki, K.
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Journal Title
Tetrahedron Letters 44
Pages: 2849-2852
Description
「研究成果報告書概要(和文)」より
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