Expression of targets for chemotherapy in primacy and metastatic cancer

2004 Fiscal Year Final Research Report Summary

• Project/Area Number: 14572149
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 応用薬理学・医療系薬学
• Research Institution: FUKUSHIMA MEDICAL UNIVERSITY (2003-2004); Tohoku University (2002)
• Principal Investigator: TAKEBAYASHI Yuji Fukushima Medical University, School of Medicine Dept of Surgery II, Associate Professor, 医学部, 講師 (70321982)
• Co-Investigator(Kenkyū-buntansha): TAKENOSHITA Seiichi Fukushima Medical University, School of Medicine Dept of Surgery II, Professor, 医学部, 教授 (10167489)
• Project Period (FY): 2002 – 2004
• Keywords: Cancer Chemotherapy / Metastasis / Membrane Transporter / DNA repair / Angiogenesis

Research Abstract

First, the expression levels of the target molecules for cancer chemotherapy such as drug transporters (ATP7B, MRP,2), DNA repair molecules (CPG, XPF) and the targets for FU such as TP, DPD, TS were examined by RTPCR and immunohistochemical analysis. The exprnssian levels of TP and TS were different between primary and metastatic lesions among the examined molecules. Next, using the transfectants of TS or TP, the enhancement of the expression levels of these molecules were examined in animal models.Unfortunately, the enhancement of these molecules were not obtained.

Research Products

• [Journal Article] Angiogenesis in colon hyperplastic polyp. (2005)
  • Author(s): Takebayashi Y.他6名
  • Journal Title: Cancer Lett. 10 Pages: 223-228
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Angiogenesis in colon hyperplastic polyp (2005)
  • Author(s): Sano Y, Maeda N, Kanzaki A, Fujii T, Ochiai A, Takenoshita S, Takebayashi Y.
  • Journal Title: Cancer Lett Feb 10;218(2) Pages: 223-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression. (2004)
  • Author(s): Takebayashi Y.他6名
  • Journal Title: Cancer Sci. 95 Pages: 851-857
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) in human hepatocellular carcinoma. (2004)
  • Author(s): Takebayashi Y.他17名
  • Journal Title: Anticancer Res. 24 Pages: 1045-1048
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Prognostic value of the Cu-transporting ATPase in ovarian carcinoma patients receiving cisplatin-based chemotherapy. (2004)
  • Author(s): Takebayashi Y.他11名
  • Journal Title: Clin Cancer Res. 15;10 Pages: 2804-2811
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression (2004)
  • Author(s): Akiyama S, Furukawa T, Sumizawa T, Takebayashi Y, Nakajima Y, Shimaoka S, Haraguchi M.
  • Journal Title: Cancer Sci. Nov;95(11) Pages: 851-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) in human hepatocellular carcinoma (2004)
  • Author(s): Sugeno H, Takebayashi Y, Higashimoto M, Ogura Y, Shibukawa G, Kanzaki A, Terada K, Sugiyama T, Watanabe K, Katoh R, Nitta Y, Fukushima T, Koyama Y, Inoue N, Sekikawa K, Ogawa K, Sato Y, Takenoshita S.
  • Journal Title: Anticancer Res. Mar-Apr;24(2C) Pages: 1045-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prognostic value of the Cu-transporting ATPase in ovarian carcinoma patients receiving cisplatin-based chemotherapy (2004)
  • Author(s): Nakayama K, Kanzaki A, Terada K, Mutoh M, Ogawa K, Sugiyama T, Takenoshita S, Itoh K, Yaegashi N, Miyazaki K, Neamati N, Takebayashi Y.
  • Journal Title: Clin Cancer Res. Apr 15;10(8) Pages: 2804-11
  • Description: 「研究成果報告書概要(欧文)」より