2003 Fiscal Year Final Research Report Summary
Approach from nutritional therapy to immune-allergic disorders
| Project/Area Number |
14580148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
食生活
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| Research Institution | JAPAN WOMEN'S UNIVERSITY |
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Principal Investigator |
SATO Kazuto Japan Women's Univ., Faculty of Home Economics, Professor, 家政学部, 教授 (40187175)
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| Project Period (FY) |
2002 – 2003
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| Keywords | immunity / allergy / nutrition / autoimmune diseases / obesity |
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| Research Abstract |
A.Allergy and nutrition
1.Obesity and immunity/allergy
1) Effect of obesity on allergic asthma
Effect of obesity on pathophysiology of antigen-specific allergic asthma was investigated by using diet induced-obese mice. Functional changes of T lymphocytes rather than immediate-type hypersensitivity was more involved in the asthma with obesity.
2) Effect of leptin in vivo on immunity with obesity
Sensitivity of lymphocyte to leptin was altered in obesity, which might relate with immuno-regulatory changes in the condition.
2.Oral tolerance and dietary fatty acids
IgE production in oral tolerance induction was altered by n-6/n-3 ratio of PUFA in dietary fatty acids, which may influence to pathophysiology of allergy.
B.Autoimmune diseases and nutrition
1.Oral tolerance induction and estrogen in arthritis model mice
Oral tolerance induction was affected by estrogen administration in arthritis, which implies the importance of hormonal condition in nutritional therapy.
2.Immunity in mother-child relationship was investigated in arthritis model.
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Research Products
(10 results)
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[Publications] Uwe Kalina, Noriko Koyama, Tomoko Hosoda, Heike Nuemberger, Kazuto Sato, Dieter Hoelzer, Frank Herweck, Tobias Manigold, Manfred V.Singer, Siegbert Rossol, Ulrich Bocker: "Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region"European Journal of Immunology. 32. 2635-2643 (2002)
Description
「研究成果報告書概要(欧文)」より
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