2004 Fiscal Year Final Research Report Summary
The mechanisms of information processing for reward and aversion in the insular cortex of monkeys and rats.
| Project/Area Number |
14580768
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Toyama Medical and Pharmaceutical University |
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Principal Investigator |
TAMURA Ryoi Toyama Med.& Pharmaceu.Univ., Medicine, Professor, 医学部, 教授 (60227296)
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| Co-Investigator(Kenkyū-buntansha) |
UWANO Teruko Toyama Med.& Pharmaceu.Univ., Medicine, Assistant Professor, 医学部, 助手 (80242486)
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| Project Period (FY) |
2002 – 2004
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| Keywords | monkeys / rats / insular cortex / behavior / single unit recording / taste responses / emotion / learning |
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| Research Abstract |
The aim of this study was to elucidate, at neuronal level, the role of the insular cortex for the expression of emotional behaviors in monkeys and rats. In the first fiscal year (2002), single neuron activity was recorded from the monkey insular cortex during performance of a delayed-response delayed-reward go/nogo task ; and responsiveness to the task was analyzed. As a result, we found that there are neurons related to attention, reward anticipation or behavioral decision making in the insular cortex ; we also found that there are functional topography in the insula. In the second fiscal year (2003), we recorded single neuron activity in the gustatory insular cortex of alert rats, and analyzed responses to rewarding or aversive taste stimuli. As a result, we found that some insular neurons responded differentially to the 4 standard taste stimuli (sweet, salty, sour and bitter). In addition to these taste cells, we found some neurons specifically responding to water or rinse. The cells best responding to salty or bitter tended not to respond to other taste stimuli but their own best stimulus, while for the sweet-best cells, the responses to sweet were almost similar to those to sour ; for the sour-best cells, the responses to sweet, sour and bitter were considerably similar. When considering the fact that sweet has innately hedonic while sour or bitter has an aversive property, the present results suggested that the insular neurons play an important role in the coding of taste quality. In the final fiscal year (2004), neural activity was recorded from the rat insular cortex during performance of a stimulus-reward/aversion association task, and responsiveness to the task was analyzed. As a result, we found that some insular neurons specifically code tones with biological significance.
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Research Products
(18 results)
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[Journal Article] Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place.2005
Author(s)
Tran A.H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., Ono, T.
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Journal Title
Proc.Natl.Acad.Sci.U.S.A. 102
Pages: 2117-2122
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Differential characteristics of face neuron responses within the anterior superior temporal sulcus of macaques.2005
Author(s)
De Souza W.C., Eifuku, S., Tamura.R., Nishijo, H., Ono, T.De Souza W.C., Eifuku, S., Tamura, R., Nishijo, H., Ono, T.
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Journal Title
J.Neurophysiol. (in press)
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Representation of place by monkey hippocampal neurons in real and virtual translocation.2003
Author(s)
Hori, E., Tabuchi, E., Matsumura, N., Tamura, R., Eifuku, S., Endo, S., Nishijo, H., Ono, T.
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Journal Title
Hippocampus 13
Pages: 190-196
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Dopamine D2 receptor-knockout changed accumbens neural response to prediction of reward associated with place in mice.2003
Author(s)
Tran, A.H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., Matsumoto, G., Ono, T.
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Journal Title
In : Cognition and Emotion in the Brain. (T.Ono, G.Matsumoto, R.R.Llinas, A.Berthoz, R.Norgren, H.Nishijo, R.Tamura (Eds.))(Elsevier)
Pages: 493-508
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Transmodal coding for reward prediction in the audiovisual thalamus.2003
Author(s)
Komura, Y., Tamura, R., Uwano, T., Nishijo H., Ono, T.
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Journal Title
In : Cognition and Emotion in the Brain. (T.Ono, G.Matsumoto, R.R.Llinas, A.Berthoz, R.Norgren, H.Nishijo, R.Tamura (Eds.))(Elsevier)
Pages: 383-396
Description
「研究成果報告書概要(和文)」より
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[Journal Article] On the organization of face memory.2003
Author(s)
Eifuku, S., de Souza, W.C., Tamura, R., Nishij o, H., Ono, T.
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Journal Title
In : Cognition and Emotion in the Brain. (T.Ono, G.Matsumoto, R.R.Llinas, A.Berthoz, R.Norgren, H.Nishijo, R.Tamura (Eds.))(Elsevier)
Pages: 73-86
Description
「研究成果報告書概要(和文)」より
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[Journal Article] A method for accurate determination of stereotaxic coordinates in single-unit recording studies in monkeys by high-resolution 3-dimensional magnetic resonance imaging.2003
Author(s)
Asahi, T., Tamura, R., Eifuku, S., Hayashi, N., Endo, S., Nishijo, H., Ono, T.
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Journal Title
Neurosci.Res. 47
Pages: 255-260
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Dopamine D2 receptor-knockout changed accumbens neural response to prediction of reward associated with place in mice.2003
Author(s)
Tran, A.H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., Matsumoto, G, Ono, T.
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Journal Title
Cognition and Emotion in the Brain (T.Ono, G Matsumoto, R.R.Llinas, A.Berthoz, R.Norgren, H.Nishijo, R.Tamura (Eds.)) (Elsevier)
Pages: 493-508
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Transmodal coding for reward prediction in the audiovisual thalamus.2003
Author(s)
Komura, Y, Tamura, R., Uwano, T., Nishijo, H., Ono, T.
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Journal Title
Cognition and Emotion in the Brain (T.Ono, G Matsumoto, R.R.Llinas, A.Berthoz, R.Norgren, H.Nishijo, R.Tamura (Eds.)) (Elsevier)
Pages: 383-396
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] On the organization of face memory.2003
Author(s)
Eifuku, S., De Souza, WC., Tamura, R., Nishijo, H., Ono, T.
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Journal Title
Cognition and Emotion in the Brain (T.Ono, G Matsumoto, R.R.Llinas, A.Berthoz, R.Norgren, H.Nishijo, R.Tamura (Eds.)) (Elsevier)
Pages: 73-86
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effects of a novel arginine-vasopressin derivative, NC-1900, on the spatial memory impairment of rats with transient forebrain ischemia.2002
Author(s)
Hori, E., Uwano, T., Tamura, R., Miyake, N., Nishijo, H., Ono, T.
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Journal Title
Cognitive Brain Res. 13
Pages: 1-15
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice.2002
Author(s)
Tran A.H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., Matsumoto, G., Ono, T.
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Journal Title
Proc.Natl.Acad.Sci.U.S.A. 99
Pages: 8986-8991
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Generators of visual evoked potentials for faces and eyes in the human brain as determined by dipole localization.2002
Author(s)
Shibata, T., Nishijo, H., Tamura, R., Miyamoto, K., Eifuku, S., Endo, S., Ono, T.
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Journal Title
Brain Topogr. 15
Pages: 51-63
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice.2002
Author(s)
Tran A.H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., Matsumoto, G., Ono, T.
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Journal Title
Proc.Natl.Acad.Sci.USA 99
Pages: 8986-8991
Description
「研究成果報告書概要(欧文)」より
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