近縁種で独立に生じた全ゲノム重複が解明する全ゲノム重複のメカニズムとインパクト

2015 Fiscal Year Annual Research Report

• Project/Area Number: 14F04382
• Research Institution: The University of Tokyo
• Principal Investigator: 岩崎 渉 東京大学, 理学(系)研究科(研究院), 准教授 (50545019)
• Co-Investigator(Kenkyū-buntansha): SRISWASDI SIRA 東京大学, 理学(系)研究科(研究院), 外国人特別研究員
• Project Period (FY): 2014-04-25 – 2017-03-31
• Keywords: バイオインフォマティクス / ゲノム / 進化

Outline of Annual Research Achievements

In this project, we aim to understand how neofunctionalization and subfunctionalization occur and whether they are driven by particular genetic elements or functions of nearby genes after genome polyploidization. Following the identification and characterization of genome polyploidization in newly sequenced fungal genomes, we investigated evolution rates among orthologs and paralogs, transcriptional orientation of newly formed adjacent genes, and conservations of stoichiometry for protein complexes and biological pathway components. Specifically, improved gene ontology annotation achieved during the last year allowed us to identify the relationship between genes in newly formed gene clusters. In the next year, we will look for sequence motifs in nearby untranslated regions that might be related to these conserved rearrangements.

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

Several unexpected discoveries were obtained in addition to those originally targeted.

Strategy for Future Research Activity

We plan to conduct in-depth genome data analysis and make scientific publications.