Calcium Signaling and Cerebellar Synaptic Circuit Development

2004 Fiscal Year Final Research Report Summary

• Project/Area Number: 15016001
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: HOKKAIDO UNIVERSITY
• Principal Investigator: WATANABE Masahiko Hokkaido Univ., Graduated School of Medicine, Prof., 大学院医学研究科, 教授 (70210945)
• Co-Investigator(Kenkyū-buntansha): FUKAYA Masahiro Hokkaido Univ., Graduated School of Medicine, Inst., 大学院医学研究科, 助手 (10360900)
• Project Period (FY): 2003 – 2004
• Keywords: synapse / development / cerebellum / glutamate receptor / climbing fiber / parallel fiber / Purkinje cell / calcium channel

Research Abstract

Synapse formation depends critically on the competition among inputs of multiple sources to individual neurons. Cerebellar Purkinje cells have highly organized synaptic wiring from two distinct sources of excitatory afferents. Single climbing fibers innervate proximal dendrites of Purkinje cells, whereas numerous parallel fibers converge on their distal dendrites. Here, we demonstrate that the P/Q-type Ca^<2+> channel a1A, a major Ca^<2+> channel subtype in Purkinje cells, is crucial for this organized synapse formation. In the alA knockout mouse, ectopic spine formation was frequently observed in proximal dendrites and somata of Purkinje cells. Innervation territory of parallel fibers was expanded proximally to innervate these ectopic spines, whereas that of climbing fibers was regressed to the basal portion of proximal dendrites and somata. Furthermore, multiple climbing fibers, consisting of a strong climbing fiber and one or a few weaker ones, persisted in the majority of Purkinje cells and were co-wired to the basal somatodendritic domain. The lack of alA, therefore, results in the survival of parallel fibers and surplus climbing fibers, which should normally be expelled from the compartment innervated by the main climbing fiber. We conclude that a P/Q-type Ca^<2+> channel alA fuels both heterosynaptic competition between climbing fibers and parallel fibers and homosynaptic competition among multiple climbing fibers. This molecular function facilitates the distal extension of climbing fiber innervation along Purkinje cell's dendritic tree and also establishes mono climbing fiber innervation of individual Purkinje cells.

Research Products

• [Journal Article] Rescue of abnbormal phenotypes of the _2 glutamate receptor-null mice by mutant _2 transgenes. (2005)
  • Author(s): Hirai, H., Miyazaki, T., Mishina, M., Watanabe, M., Yuzaki, M.
  • Journal Title: EMBO report 6 Pages: 90-95
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Retinotectal transmission in the optic tectum of rainbow trout. (2005)
  • Author(s): Kinoshita, M., Fukaya, M., Tojima, T., Kojima, S., Ando, H., Watanabe, M., Urano, A., Ito,E.
  • Journal Title: J.Comp.Neurol. 484 Pages: 249-259
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Evidence for creatine biosynthesis in Muller glial cells. (2005)
  • Author(s): Nakashima, T., Tomi, M., Tachikawa, M., Watanabe, M., Terasaki, T., Hosoya, K.
  • Journal Title: Glia 52 Pages: 47-52
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] NR2-to-NR3B subunit conversation of NMDA receptor in early postnatal motoneurons. (2005)
  • Author(s): Fukaya, M., Hayashi, Y., Watanabe, M.
  • Journal Title: Eur.J.Neurosci. 21 Pages: 1432-1436
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Control of synaptic connection by glutamate receptor _2 in the mature cerebellum. (2005)
  • Author(s): Takeuchi, M., Miyazaki, T., Watanabe, M., Mori, H., Sakimura, K., Mishina,M.
  • Journal Title: J. Neurosci. 484 Pages: 249-259
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification and characterization of a novel member of murine semaphoring family. (2005)
  • Author(s): Taniguchi, M., Masuda, T., Fukaya, M., Kataoka, H., Mishina, M., Yaginuma, H., Watanabe, M., Shimizu, T.
  • Journal Title: Genes to Cells. 10 Pages: 785-792
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Ptf1a,a bHLH transcriptional gene, defines GABAergic neuronal gates in cerebellum. (2005)
  • Author(s): Hoshino, M., Nakamura, S., Mori, K., Kawauchi, T., Terano, M., Nishimura, Y.V., Fukuda, A., Matsuo, N., Sone, M., Watanabe, M., Terashima, T., Wright, C.V.E., Kawaguchi, Y., Nakao, K., Nabeshima,Y.
  • Journal Title: Neuron 47 Pages: 201-213
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The delta2 "glutamate receptor is not activated by glutamate-likeligand. (2005)
  • Author(s): Hirai, H., Miyazaki, T., Mishina, M., Watanabe, M., Yuzaki, M.
  • Journal Title: EMBO report. 6 Pages: 90-95
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Retinotectal transmission in the optic tectum of rainbow trout. (2005)
  • Author(s): Kinoshita, M., Fukaya, M., Tojima, T., Kojima, S., Ando, H., Watanabe, M., Ito, E.
  • Journal Title: J.Comp.Neurol. 484 Pages: 249-259
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evidence for creatine biosynthesis in Muller glial cells. (2005)
  • Author(s): Nakashima, T., Tomi, M., Tachikawa, M., Watanabe, M., Terasaki, T., Hosoya, K.
  • Journal Title: Glia. 52 Pages: 47-52
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] NR2-to-NR3B subunit conversion of NMDA receptor in early Postnatal motoneurons. (2005)
  • Author(s): Fukaya, M., Hayashi, Y., Watanabe, M.
  • Journal Title: Eur.J.Neurosci. 21 Pages: 1432-1436
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Control of synaptic connection by glutamate receptor d2 in the mature cerebellum. (2005)
  • Author(s): Takeuchi, T., Miyazaki, T., Watanabe, M., Mori, H., Sakimura, K., Mishina, M.
  • Journal Title: J.Neurosci. 484 Pages: 249-259
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification and characterization of a novel member of murine semaphorin family. (2005)
  • Author(s): Taniguchi, M., Masuda, T., Fukaya, M., Kataoka, H., Mishina, M., Yaginuma, H., Watanabe, M., Shimizu, T.
  • Journal Title: Genes to Cells. 10 Pages: 785-792
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal gates in cerebellum. (2005)
  • Author(s): Hoshino, M., Nakamura, S., Mori, K., Kawauchi, T., Terano, M., Nishimura, Y.V., Fukuda, A., Matsuo, N., Sone, M., Watanabe, M., Terashima, T., Wright, C.V.E., Kawaguchi, Y., Nakao, K., Nabeshima, Y.
  • Journal Title: Neuron 47 Pages: 201-213
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] P/Q-type Ca^<2+> channel α1A regulates synaptic competition on developing cerebellar Purkinje cells (2004)
  • Author(s): Miyazaki, M., Hashimoto, K., Shin H.-S., Kano, M., Watanabe, M.
  • Journal Title: J. Neurosci. 24 Pages: 1734-1743
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mammalian septin Sept2 modulates the activity of GLAST, a glutamate transporter in astrocytes. (2004)
  • Author(s): Kinoshita, N., Kimura, K., Matsumoto, N., Watanabe, M., Fukaya, M., Ide, C.
  • Journal Title: Genes Cells 9 Pages: 1-14
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality. (2004)
  • Author(s): Yoshida, K., Furuya, S., Osuka, S., Mitoma, J., Shinoda, Y., Watanabe, M., Azuma, N., Tanaka, H., Hashikawa, T., Itohara, S., Hirabayashi, Y.
  • Journal Title: J. Biol. Chem. 279 Pages: 3573-3577
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. (2004)
  • Author(s): Somogyi, J., Baude, A., Omori, Y., Shimizu, H., Mestikawy, S.E., Fukaya, M., Ryuichi, S., Watanabe, M., Somogyi, P.
  • Journal Title: Eur. J. Neurosci. 19 Pages: 552-569
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Two distinct classes of muscarinic action on hippoccampal inhibitory synapses : M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signaling. (2004)
  • Author(s): Fukudome, Y., Ohno-Shosaku, T., Matsui, M., Omori, Y., Fukaya, M., Taketo, M., Watanabe, M., Manabe, M., Kano, M.
  • Journal Title: Eur. J. Neurosci. 19 Pages: 2682-2692
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-brain barrier. (2004)
  • Author(s): Nakashima, T., Tomi, M., Katayama, K., Tachikawa, M., Watanabe, M., Terasaki, T., Hosoya, K.
  • Journal Title: J. Neurochem. 89 Pages: 1454-1461
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest novel neuron-glial relationship for brain energy homeostasis. (2004)
  • Author(s): Tachikawa, M., Fukaya, M., Terasaki, T., Ohtsuki, S., Watanabe, M.
  • Journal Title: Eur. J. Neurosci. 20 Pages: 144-160
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Immunolocalization of metabotropic glutamate receptor 1α (mGluR1α) in Distinct classes of interneuron in the CA1 region of the rat hippocampus. (2004)
  • Author(s): Ferraguti, F., Cobden, P., Pollard, M., Cope, D., Shigemoto, R., Watanabe, M., Somogy, P.
  • Journal Title: Hippocampus 14 Pages: 193-215
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen unmasking method. (2004)
  • Author(s): Nagy, G.G., Al-Ayyan, M., Andrew, D., Fukaya, M., Watanabe, M., Todd, A.J.
  • Journal Title: J. Neurosci. 24 Pages: 5766-5777
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] NMDA Receptor GluR ε/NR2 subunits are essential for postsynaptic localization and protein stability of GluRζ 1/NR1 subunit. (2004)
  • Author(s): Abe, M., Fukaya, M., Yagi, T., Mishina M., Watanabe, M., Sakimura, K.
  • Journal Title: J. Neurosci. 24 Pages: 9292-9304
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. (2004)
  • Author(s): Hama, K., Aoki, J., Fukaya, M., Kishi, Y, Sakai, T., Suzuki, R., Ohta, H., Yamori, T., Watanabe, M., Chun, J., Arai, H.
  • Journal Title: J. Biol. Chem. 279 Pages: 17634-17639
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Changes of high-affinity choline transporter expression during degeneration and regeneration of hypoglossal nerves in mice. (2004)
  • Author(s): Oshima, S., Yamada, K., Shirakawa, T., Watanabe, M.
  • Journal Title: Neurosci. Lett. 365 Pages: 97-101
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family. (2004)
  • Author(s): Kawano H, Nakatani T, Mori T, Ueno S, Fukaya M, Abe A, Kobayashi M, Toda F, Watanabe M, Matsuoka I
  • Journal Title: Mol Brain Res. 125 Pages: 60-75
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Functional expression of rat ABCG2 and its enhancement by astrocyte-derived soluble factor(s). (2004)
  • Author(s): Hori, S., Ohtsuki, S., Tachikawa, M., Kimura, N., Kondo, T., Watanabe, M., Nakashima, E., Terasaki, T.
  • Journal Title: J. Neurochem. 90 Pages: 526-536
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E. (2004)
  • Author(s): Kitamura, H.W., Hamanaka, H., Watanabe, M., Wada, K., Yamazaki, C., Fujita, S.C., Manabe, T., Nukina, N.
  • Journal Title: Neurosci. Lett. 369 Pages: 173-178
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B cclathrin adaptor. (2004)
  • Author(s): Nakatsu, F., OKada, M., Mori, F., Kamazawa, N., Iwasa, H., Zhu, G., Kasagi, Y., Kamiya, H., Harada, A., Nishimura, K., Takeuchi, A., Miyazaki, T., Watanabe, M., Yuasa, S., Manabe, T., Wakabayashi, K., Kaneko, S., Saito, T., Ohno, H.
  • Journal Title: J. Cell Biol. 167 Pages: 293-302
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Upreguration of GluR2 decrease intracellular Ca2+ following ischemia in developing gerbils. (2004)
  • Author(s): Oguro, K., Miyawaki, T., Yokota, H., Kato, K., Kamiya, T., Katayama, Y., Fukaya, M., Watanabe, M., Shimazaki, K.
  • Journal Title: Neurosci. Lett. 364 Pages: 101-105
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Signaling complex formation of phospholipase Cβ4 with mGluR1α and IP3R1 at the perisynapse and endoplasmic reticulum in the mouse brain. (2004)
  • Author(s): Nakamura, M., Sato, K., Fukaya, M., Araishi, K., Aiba, A., Kano, M., Watanabe, M.
  • Journal Title: Eur. J. Neurosci 20 Pages: 2929-2944
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A novel action of stargazin as an enhancer of AMPA receptor activity. (2004)
  • Author(s): Yamazaki, M., Ohno-Shosaku, T., Fukaya, M., Kano, M., Watanabe, M., Sakimura, K.
  • Journal Title: Neurosci. Res. 50 Pages: 369-374
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synaptic distribution of the NR1, NR2A, and NR2B subunits of the NMDA receptor in the rat lumbar spinal cord revealed with an antigen unmasking technique. (2004)
  • Author(s): Nagy, G.G., Watanabe.M., Fukaya, M., Todd, R.
  • Journal Title: Eur. J. Neurosci 20 Pages: 3301-3312
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] P/Q-type Ca^<2+> channel α1A regulates synaptic competition on Developing cerebellar Purkinje cells. (2004)
  • Author(s): Miyazaki, M., Hashimoto, K., Shin H.-S., Kano, M., Watanabe, M.
  • Journal Title: J.Neurosci. 24 Pages: 1734-1743
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mammalian septin Sept2 modulates the activity of GLAST, a glutamate transporter in astrocytes. (2004)
  • Author(s): Kinoshita, N., Kimura, K., Matsumoto, N., Watanabe.M..Fukaya, M., Ide, C.
  • Journal Title: Genes Cells. 9 Pages: 1-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality. (2004)
  • Author(s): Yoshida, K., Furuya, S., Osuka, S., Mitoma, J., Shinoda, Y., Watanabe, M., Azuma, N., Tanaka, H., Hashikawa, T., Itohara, S., Hirabayashi, Y.
  • Journal Title: J.Biol.Chem. 279 Pages: 3573-3577
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] GABAergic basket cells expressing cholecystokinin contain Vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. (2004)
  • Author(s): Somogyi, J., Baude, A., Omori, Y., Shimizu, H., Mestikawy, S.E., Fukaya, M., Ryuichi, S., Watanabe.M., Somogyi, P.
  • Journal Title: Eur.J.Neurosci. 19 Pages: 552-569
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Two distinct classes of muscarinic action on hippoccampal inhibitory synapses : M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signaling. (2004)
  • Author(s): Fukudome, Y., Ohno-Shosaku, T., Matsui, M., Omori, Y., Fukaya, M., Taketo, M., Watanabe, M., Manabe, M., Kano, M.
  • Journal Title: Eur.J.Neurosci. 19 Pages: 2682-2692
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-brain barrier. (2004)
  • Author(s): Nakashima, T., Tomi, M., Katayama, K., Tachikawa, M., Watanabe, M., Terasaki, T., Hosoya, K.
  • Journal Title: J.Neurochem. 89 Pages: 1454-1461
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Distinct cellular expressions of creatine synthetic enzyme GAMT And creatine kinases uCK-Mi and CK-B suggest novel neuron-gliarelationship for brain energy homeostasis. (2004)
  • Author(s): Tachikawa, M., Fukaya, M., Terasaki, T., Ohtsuki, S., Watanabe.M.
  • Journal Title: Eur.J.Neurosci. 20 Pages: 144-160
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Immunolocalization of metabotropic glutamate receptor 1a (mGluR1a) in distinct classes of interneuron in the CA1 region of the rat hippocampus. (2004)
  • Author(s): Ferraguti, F., Cobden, P., Pollard, M., Cope, D., Shigemoto, R., Watanabe, M., Somogy, P.
  • Journal Title: Hippocampus. 14 Pages: 193-215
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen unmasking method. (2004)
  • Author(s): Nagy, G.G., Al-Ayyan, M., Andrew, D., Fukaya, M., Watanabe, M., Todd, A.J.
  • Journal Title: J.Neurosci. 24 Pages: 5766-5777
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] NMDA Receptor GluRe/NR2 subunits are essential for postsynaptic localization and protein stability of GluRz1/NR1 subunit. (2004)
  • Author(s): Abe, M., Fukaya, M., Yagi, T., Mishina, M., Watanabe.M., Sakimura, K.
  • Journal Title: J.Neurosci. 24 Pages: 9292-9304
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. (2004)
  • Author(s): Hama, K., Aoki, J., Fukaya, M., Kishi, Y., Sakai, T., Suzuki, R., Ohta, H., Yamori, T., Watanabe.M., Chun, J., Arai, H.
  • Journal Title: J.Biol.Chem. 279 Pages: 17634-17639
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Changes of high-affinity choline transporter expression during degeneration and regeneration of hypoglossal nerves in mice. (2004)
  • Author(s): Oshima, S., Yamada, K., Shirakawa, T., Watanabe, M.
  • Journal Title: Neurosci.Lett. 97 Pages: 97-101
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family. (2004)
  • Author(s): Kawano H, Nakatani T, Mori T, Ueno S, Fukaya M, Abe A, Kobayashi M, Toda F, Watanabe M, Matsuoka I.
  • Journal Title: Mol Brain Res. 125 Pages: 60-75
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional expression of rat ABCG2 and its enhancement by astrocyte-derived soluble factor(s). (2004)
  • Author(s): Hori, S., Ohtsuki, S., Tachikawa, M., Kimura, N., Kondo, T., Watanabe, M., Nakashima, E., Terasaki, T.
  • Journal Title: J.Neurochem. 90 Pages: 526-536
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E. (2004)
  • Author(s): Kitamura, H.W., Hamanaka, H., Watanabe, M., Wada, K, Yamazaki, C., Fujita, S.C., Manabe, T., Nukina, N.
  • Journal Title: Neurosci.Lett. 369 Pages: 173-178
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B cclathrin adaptor. (2004)
  • Author(s): Nakatsu, F., Okada, M., Mori, F., Kamazawa, N., Iwasa, H., Zhu, G., Kasagi, Y., Kamiya, H., Harada, A., Nishimura, K., Takeuchi, A., Miyazaki, T, Watanabe, M., Yuasa, S., Manabe, T, Wakabayashi, K., Kaneko, S., Saito, T., Ohno, H.
  • Journal Title: J.Cell Biol. 167 Pages: 293-302
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Upreguration of GluR2 decrease intracellular Ca2+ following ischemia in developing gerbils. (2004)
  • Author(s): Oguro, K., Miyawaki, T., Yokota, H., Kato, K., Kamiya, T., Katayama, Y., Fukaya, M., Watanabe.M., Shimazaki, K.
  • Journal Title: Neurosci.Lett. 364 Pages: 101-105
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Signaling complex formation of phospholipase Cb4 with mGluR1a and IP3R1 at the perisynapse and endoplasmic reticulum in the mouse brain. (2004)
  • Author(s): Nakamura, M., Sato, K., Fukaya, M., Araishi, K., Aiba, A., Kano, M., Watanabe, M.
  • Journal Title: Eur.J.Neurosci. 20 Pages: 2929-2944
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A novel action of stargazin as an enhancer of AMPA receptor activity. (2004)
  • Author(s): Yamazaki, M., Ohno-Shosaku, T., Fukaya, M., Kano, M., Watanabe, M., Sakimura, K.
  • Journal Title: Neurosci.Res. 50 Pages: 369-374
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synaptic distribution of the NR1, NR2A, and NR2B subunits of the NMDA receptor in the rat lumbar spinal cord revealed with an antigen unmasking technique. (2004)
  • Author(s): Nagy, G.G., Watanabe, M., Fukaya, M., Todd, R.
  • Journal Title: Eur.J.Neurosci 20 Pages: 33013312
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse with transient expression in developing capillaries. (2003)
  • Author(s): Sakai, K., Shimizu, H., Koike, T., Furuya S., Watanabe, M.
  • Journal Title: J. Neurosci. 17 Pages: 550-560
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of Insulin-like Growth Factor I on Climbing Fiber Synapse Elimination during Cerebellar Development. (2003)
  • Author(s): Kakizawa, S., Yamada, K., Watanabe, M., Kano, M.
  • Journal Title: Eur. J. Neurosci. 17 Pages: 545-554
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. (2003)
  • Author(s): Fukaya, M., Kato, A., Lovett, C., Tonegawa, S., Watanabe.M.
  • Journal Title: Proc. Natl. Acad. Sci. USA 100 Pages: 4855-4860
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transient neonatal expression of NR2B/2D subunit mRNAs of the N-methyl-D-aspartate receptor in the parasympathetic preganglionic neurons in the rat spinal cord. (2003)
  • Author(s): Shibata, T., Watanabe.M., Ichikawa, R., Ameda, K., Koyanagi, T.
  • Journal Title: Dev. Brain Res. 140 Pages: 263-268
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] High level of mGluR7 in the presynaptic active zones of select populations of GABAergic termipals innervating interneurones in the rat hippocampus. (2003)
  • Author(s): Somogyi, P., Dalezios, Y., Lujan, R., Roberts, D.B., Watanabe, M., Shigemoto, R.
  • Journal Title: Eur. J. Neurosci. 17 Pages: 2503-2520
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Developmental switching of vesicular glutamate transporters at parallel fiber-Purkinje cell synapses. (2003)
  • Author(s): Miyazaki, T., Fukaya, M., Shimizu, H, Watanabe, M.
  • Journal Title: Eur. J. Neurosci 17 Pages: 2563-2572
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Organization of postsynaptic density proteins and glutamate receptors in axodendritic and dendrodendritic synapses of the rat olfactory bulb. (2003)
  • Author(s): Sassoe-Pngnetto, M., Utvik, J.K., Camoletto, P., Watanabe.M., Stephenson, F.A., Bredt, D.S., Otternen, O.P.
  • Journal Title: J. Comp. Neurol. 463 Pages: 237-248
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of thalamic phospholipase Cβ4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain. (2003)
  • Author(s): Miyata, M., Kashiwadani, H., Fukaya, M., Hayashi, T., Wu, D., Suzuki, T., Watanabe, M., Kawakami, Y.
  • Journal Title: J. Neurosci 23 Pages: 8098-8108
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons. (2003)
  • Author(s): Jourdi, H., Iwakura, Y., Narisawa-Saito, M., Ibaraki, K., Xiong, H., Watanabe, M., Hayashi, Y., Takei, N., Nawa, H.
  • Journal Title: Dev. Biol. 263 Pages: 216-230
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Selective expression of L-serine synthetic enzyme 3PGDH in Schwann cells, perineuronal glia, and endoneurial fibroblasts along sciatic nerves and its upregulation after crush injury. (2003)
  • Author(s): Yamashita, N., Sakai, K., Furuya, S., Watanabe, M.
  • Journal Title: Arch. Histol. Cytol. 66 Pages: 429-436
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua. (2003)
  • Author(s): Takahashi, Y., Mod, H., Mishina, M., Watanabe, M., Fujiwara, T., Shimomura, J., Aiba, H., Miyajima, T., Saito, Y., Nezu, A., Nishida, H., Imai, K., Saskaguchi, N, Kondo, N.
  • Journal Title: Neurology 61 Pages: 891-896
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Novel neuroglial and glioglial relationships mediated by L-serine metabolism. (2003)
  • Author(s): Furuya, S., Watanabe, M.
  • Journal Title: Arch. Histol. Cytol. 66 Pages: 109-121
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse with transient expression in developing capillaries. (2003)
  • Author(s): Sakai K, Shimizu H, Koike T, Furuya S, Watanabe M
  • Journal Title: J Neurosci. 23 Pages: 550-560
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of insulin-like growth factor I on climbing fiber synapse elimination during cerebellar development. (2003)
  • Author(s): Kakizawa S, Yamada K, Watanabe M, Kano M
  • Journal Title: Eur J Neurosci. 17 Pages: 545-554
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. (2003)
  • Author(s): Fukaya M, Kato A, Lovett C, Tonegawa S, Watanabe M
  • Journal Title: Proc Natl Acad Sci USA. 100 Pages: 4855-4860
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transient neonatal expression of NR2B/2D subunit mRNAs of the N-methyl-D-aspartate receptor in the parasympathetic preganglionic neurons in the rat spinalcord. (2003)
  • Author(s): Shibata T, Watanabe M, Ichikawa R, Ameda K, Koyanagi T.
  • Journal Title: Dev.Brain Res. 140 Pages: 263-268
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurones in the rathippocampus (2003)
  • Author(s): Somogyi, P., Dalezios, Y., Lujan, R., Roberts, D.B., Watanabe.M., Shigemoto, R.
  • Journal Title: Eur. J. Neurosci. 17 Pages: 2503-2520
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Developmental switching of vesicular glutamate transporters at parallel fiber-Purkinjecell synapses. (2003)
  • Author(s): Miyazaki, T., Fukaya, M., Shimizu, H, Watanabe.M.
  • Journal Title: Eur.J.Neurosci. 17 Pages: 2563-2572
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Organization of postsynaptic density proteins and glutamate receptors in axodendritic and dendrodendritic synapses of the rat olfactory bulb. (2003)
  • Author(s): Sassoe-Pngnetto, M., Utvik, J.K., Camoletto, P., Watanabe.M., Stephenson, F.A., Bredt, D.S., Otternen, O.P.
  • Journal Title: J.Comp.Neurol. 463 Pages: 237-248
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of thalamic phospholipase C β 4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain. (2003)
  • Author(s): Miyata, M., Kashiwadani, H., Fukaya, M., Hayashi, T., Wu, D., Suzuki, T., Watanabe, M., Kawakami, Y.
  • Journal Title: J.Neurosci. 23 Pages: 8098-8108
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons. (2003)
  • Author(s): Jourdi, H., lwakura, Y., Narisawa-Saito, M., lbaraki, K., Xiong, H., Watanabe, M., Hayashi, Y., Takei, N., Nawa, H.
  • Journal Title: Dev.Biol. 263 Pages: 216-230
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua. (2003)
  • Author(s): Takahashi, Y., Mori, H., Mishina, M., Watanabe, M., Fujiwara, T, Shimomura, J., Aiba, H., Miyajima, T., Saito, Y., Nezu, A., Nishida, H., Imai, K, Saskaguchi, N, Kondo, N.
  • Journal Title: Neurol. 61 Pages: 891-896
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Novel neuroglial and glioglial relationships mediated by L-serine metabolism. (2003)
  • Author(s): Furuya, S., Watanabe, M.
  • Journal Title: Arch.Histol.Cytol. 66 Pages: 109-121
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Selective expression of L-serine synthetic enzyme 3PGDH in Schwann cells, perineuronal glia, and endoneurial fibroblasts along sciatic nerves and its upregulation after crush injury. (2003)
  • Author(s): Yamashita, N., Sakai, K., Furuya, S., Watanabe.M.
  • Journal Title: Arch.Histol.Cytol. 66 Pages: 429-436
  • Description: 「研究成果報告書概要(欧文)」より