2003 Fiscal Year Annual Research Report

アディポミクス、脂肪細胞の機能世界と破綻病態の解明

Research Project

Project/Area Number	15081101
Research Institution	Osaka University
Principal Investigator	松澤佑次大阪大学, 医学系研究科, 名誉教授 (70116101)
Co-Investigator(Kenkyū-buntansha)	矢田俊彦自治医科大学, 医学研究科, 教授 (60166527) 斉藤昌之北海道大学, 獣医学研究科, 教授 (80036441) 船橋徹大阪大学, 医学系研究科, 講師 (60243234)
Keywords	内臓脂肪 / アディポサイトカイン / 脂肪細胞 / 発現遺伝子 / 分化
Research Abstract	本プロジェクトは「食」というヒトを含む動物の根元的事象と深く関わりなから、これまであまり研究されてこなかった脂肪脂肪の起源や生命装置、特にアデイポサイトカインと呼ぶ内分泌機能などの機能世界を明らかにする「アデイポミクス」という新分野を確立し、脂肪細胞機能の破綻という観点から、動脈硬化、糖尿病、癌を初めとする過栄養が関与するとされる疾患群の病態メカニズムや治療戦略を、多数の研究分野から研究者を結集して取り組み、「脂肪細胞ワールド」の全貌を明らかにしようとするものである。本年度は研究班の立ち上げにあたって、まず1)平成15年11月には総括班会議を行い、班全体の計画、構成について協議した。2)平成16年1月には、総括班班員、計画研究者、評価委員を含めた班会議を行い、班全体が充分な成果を得られるよう、各研究の計画内容を発表し、評価を行った。このような研究面での進捗を確認しながら円滑な班運営を図るとともに、本研究は、従来研究が不充分であった脂肪細胞研究の裾野を広げて研究者の参入をはかり、さらに生活習慣病をターゲットとした研究を国民に公表しうるよう、3)研究班の目的、構成を示し、成果を公表できるように、ホームページを立ち上げた。4)本研究分野への関心を促すよう、全国大学の学部生、大学院生むけの小冊子を作成し配付した。また世界に成果を公表しうるよう、5)英語版の業績集を作成し、これは毎年作成予定である。以上のように総括班として、班全体の研究が円滑に行われ最大の成果が得られるよう努力するとともに、研究分野全体が発展し、日本から世界に向け情報を発信すべく活動を行った。

Research Products

(67 results)

All Other

All Publications (67 results)

[Publications] 木村和弘, 石岡克己他: "犬と猫のレプチン-血中濃度の測定とその肥満評価への応用-"獣医畜産情報. 56. 43-46 (2003)
[Publications] 斉藤昌之: "エネルギー消費の自律的調節と肥満に関する分子栄養学的研究"日本栄養・食糧学会誌. 56. 33-39 (2003)
[Publications] Makondo, K., Kimura, K., Kitamura, N., Kitamura, T., Yamaji D., et al.: "Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca- and phosphoinsitide 3-kinase/Akt-dependent phosphorylation in aortic endothelial cells."Biochem.J.. 374. 63-69 (2003)
[Publications] 大橋敦子, 斉藤昌之: "共役脂肪酸の体脂肪低減効果とインスリン抵抗性・脂肪肝"胞満研究. 9. 128-135 (2003)
[Publications] Shibate, H., Sasaki, N.et al.: "Feline Leptin : Immunogenic and Biological Activities of the Recombinant Protein, and Its Measurement by ELISA."J.Vet.Med.Sci.. 65. 1207-1211 (2003)
[Publications] Kitamura, T., Kimura, K., Makondo, K.et al.: "Proinsulin C-peptide increases nitric oxide production by enhancing mitogen-activated protein-kinase-depentent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats."Diabetologia.. 46. 1698-1705 (2003)
[Publications] T.Asaki et al.: "Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo"Mol.Cell.Endocrinol.. in press. (2004)
[Publications] M.Affolter et al.: "Tube or not tube : remodelling epithelial tissues by branching morphogenesis"Dev.Cell. 4. 11-18 (2003)
[Publications] N.Kusu et al.: "Sclerostin is a novel secreted osteoblast-derived bone morhogenetic protein (BMP) antagonist with unique ligand specificity"J.Biol.Chem.. 278. 24113-24117 (2003)
[Publications] R.C.Burns et al.: "Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mice"Dev.Biol.. 265. 61-74 (2004)
[Publications] J.Laurikkala et al.: "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF and SHH signals from the tooth enamel knot"Dev.Biol.. 264. 91-105 (2003)
[Publications] S.Ohmachi et al.: "Peferential Neurotrophic Activity of Fibroblast Growth factor (FGF)-20 for Dopaminergic Neurons through FGF Receptor-1c"J.Neurosci.Res.. 72. 436-443 (2003)
[Publications] H.Masuzaki, J.S.Flier et al.: "Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice."J.Clin.Invest.. 112. 83-90 (2003)
[Publications] H.Masuzaki, J.S.Flier: "Tissue-specific glucocorticoid reactivating enzyme, 11□-hydroxy steroid dehydrogenase type 1(11□-HSD1). -A promising drug target for the treatment of the Metabolic Syndrome-"Curr.Drug Targets Immune Endocrinol.Metab.Disord.. 3. 249-256 (2003)
[Publications] A.Takahashi-Yasuno, H.Masuzaki (corresponding author)et al.: "Leptin receptor (Ob-R) Arg223Gln polymorphism is associated with serum cholesterol elevation and impairment of cholesterol lowering effect by simvastatin in Japanese men."Diabetes Res.Clin.Pract.. 62. 169-175 (2003)
[Publications] H.Shinyama, H.Masuzaki et al.: "Regulation of melanocortin-4 receptor signaling : Agonist-mediated desensitization and internalization."Endocrinology. 144. 1301-1314 (2003)
[Publications] N.M.Morton, H.Masuzaki, et al.: "Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11□-hydroxysteroid dehydrogenase type-1 deficient mice."Diabetes. in press. (2004)
[Publications] Iwaki M, Matsuda M, Maeda N, et al.: "Induction ofadiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors"Diabetes. 52(7). 1655-1663 (2003)
[Publications] Kohno D., Gao H-G., Muroya S., Kikuyama S., Yada T: "Ghrelin directly interacts with NPY-containing neurons in the rat arcuate nucleus : Ca2+ signaling via protein kinase A- and N-type channel-dependent Ca2+ mechanisms and cross-talk with leptin and orexin."Diabetes. 52. 948-956 (2003)
[Publications] Funahashi H, Yada T, Suzuki R, Shioda S: "Distribution, function, and properties of leptin receptors in the brain."Cytol(Int.Rev.). 224. 1-27 (2003)
[Publications] Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Sakurai T, Goto K: "Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins."J.Pharmacol.Sci.. 92. 259-266 (2003)
[Publications] Nakata M, Yada T.: "Nitric Oxide-mediated insulin secretion in response to citrulline in islet b-cells"Pancreas. 27. 209-213 (2003)
[Publications] Rokkaku K, Onaka T, Okada N, Ideno J, Kawakami A, Honda K, Yada T, Ishibashi S: "Neuromedin U facilitates oxytocin release from the pituitary via beta adrenoceptors."Neuroreport. 14. 1997-2000 (2003)
[Publications] Muroya S., Funahashi H., et al.: "Orexins(Hypocretins) Directly Interacts with Neuropeptide Y, POMC and Glucose-Responsive Neurons to Regulate Ca2+ Signaling in a Reciprocal Manner to Leptin : Orexigenic Neuronal Pathways in the Mediobasal Hypothalamus."Eur.J.Neurosci.. in press. (2004)
[Publications] Kamada Y et al.: "Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin."Gastroenterology. 125(6). 1796-1807 (2003)
[Publications] Matsuzawa Y et al.: "Importance of adipocytokines in obesity-related diseases"Horm Res. 60. 56-59 (2003)
[Publications] Miyoshi Y et al.: "Association of serum adiponectin levels with breast cancer risk."Clin Cancer Res. 9(15). 5699-5704 (2003)
[Publications] Ouchi N et al.: "Obesity, adiponectin and vascular inflammatory disease."Curr Opin Lipidol. 14(6). 561-566 (2003)
[Publications] Nagasawa A et al.: "Divergent effects of soy protein diet on the expression of adipocytokines"Biochem Biophys Res Commun. 311(4). 909-914 (2003)
[Publications] Ouchi N et al.: "Association of hypoadiponectinemia with impaired vasoreactivity."Hypertension. 42(3). 231-234 (2003)
[Publications] Kishida K et al.: "Disturbed secretion of mutant adiponectin associated with the metabolic syndrome."Biochem Biophys Res Commun.. 306(1). 286-292 (2003)
[Publications] Kojima S et al.: "The variation of plasma concentrations of a novel, adipocyte derived protein, adiponectin, in patients with acute myocardial infarction."Heart. 89(6). 667 (2003)
[Publications] Zoccali C et al.: "Adiponectin is markedly increased in patients with nephrotic syndrome and is related to metabolic risk factors."Kidney Int Suppl. 84. S98-S102 (2003)
[Publications] Nagasawa A et al.: "Effects of soy protein diet on the expression of adipose genes and plasma adiponectin."Horm Metab Res. 34(11-12). 635-639 (2003)
[Publications] Ouchi N et al.: "Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue."Circulation. 107(5). 671-674 (2003)
[Publications] Kumada M et al.: "CAD Study Group. Coronary artery disease. Association of hypoadiponectinemia with coronary artery disease in men."Arterioscler Thromb Vase Biol.. 23(1). 85-89 (2003)
[Publications] Ouchi N et al.: "Association of hypoadiponectinemia with impaired vasoreactivity."Hypertension.. 42(3). 231-234 (2003)
[Publications] T.Nakagawa et al.: "Antiobesity and antidiabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance."Int.J.Obes.. 27. 557-565 (2003)
[Publications] K.Yamahara et al.: "Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration."Proc.Natl.Acad.Sci.USA. 100. 3404-3409 (2003)
[Publications] N.Satoh et al.: "Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect."Diabetes Care. 26. 2493-2499 (2003)
[Publications] F.Miyanaga et al.: "Leptin as an adjunct of insulin therapy in insulin-dependent diabetes."Diabetologia. 46. 1329-1337 (2003)
[Publications] A.Takahashi-Yasuno et al.: "Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men."Diabetes Res.Clin.Pract.. 62. 169-175 (2003)
[Publications] Kamei Y, et al.: "Identification of PPARγ coactivator 1β/ERR ligand 1 as an estrogen-related receptor protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity in mice."Proc.Natl.Acad.Sci.U.S.A.. 100. 12378-12383 (2003)
[Publications] Takahashi N, et al.: "Abietic acid activates peroxisome proliferator-activated receptor-γ(PPARγ)in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism."FEBS Lett.. 550. 190-194 (2003)
[Publications] Kim C.-S, et al.: "Macrophage inflammatory protein-related protein-2, a novel CC chemokine, can regulate preadipocyte migration and adipocyte differentiation."FEBS Lett.. 548. 125-130 (2003)
[Publications] Kamei Y, et al.: "A forkhead transcription factor FKHR up-regulates lipoprotein lipase expression in skeletal muscle"FEBS Lett.. 536. 232-236 (2003)
[Publications] Kim C.-S, et al.: "Capsaicin exhibits anti-inflammatory property by inhibiting IkB-α degradation in LPS-stimulated peritoneal macrophages."Cellular Signalling. 15. 299-306 (2003)
[Publications] Kageyama H, et al.: "Fasting increases gene expressions of uncoupling proteins and peroxisome proliferator-activated receptor-γ in brown adipose tissue of ventromedial hypothalamus-lesioned rats."Life Sciences. 72. 3035-3046 (2003)
[Publications] Mae T, et al.: "A licorice ethanolic extract with PPAR-γ ligand-binding activity affects diabetes in KK-Ay mice, abdominal obesity in diet-Induced obese C57BL mice and Hypertension in spontaneously hypertensive rats."J.Nutrition. 133. 3369-3377 (2003)
[Publications] Masuda Y, et al.: "Up-regulation of uncoupling proteins (UCPs) by oral administration of capsiate, a non-pungent capsaicin analog."J.Appl.Physiol.. 95. 2408-2415 (2003)
[Publications] Kuroda M, et al.: "Phenolics with PPAR-γ ligand-binding activity obtained from : Licorice (Glycyrrhiza uralensis roots ) and ameliorative effects of glycilin on genetically diabetic KK-A^y mice."Bioorg.Med.Chem.Lett.. 13. 4267-4272 (2003)
[Publications] Yu R, et al.: "Involvement of leukotactin-1, a novel CC chemokine, in human atherosclerosis."Atherosclerosi. In press. (2004)
[Publications] Tsuda T, et al.: "Anthocyanin enhances adipocytokine secretion and adipocyte specific gene expression in Isolated Rat adipocytes."Biochem.Biophys.Res.Commun. 316. 149-157 (2004)
[Publications] Inoue H et al.: "Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo."Nature Medicine. 10・2. 168-174 (2004)
[Publications] Sakaue H et al.: "Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes"Journal of Biological Chemistry. 278. 38870-38874 (2003)
[Publications] Matsumoto M et al.: "PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity."Journal of Clinical Investigation. 112・6. 935-944 (2003)
[Publications] Shimoaka T et al.: "Impairment of bone healing by insulin receptor substrate-1 deficiency."J Biol Chem.. Epub ahead of print. (2004)
[Publications] Fukao T, Terauchi Y, Kadowaki T, Koyasu S.: "Role of phosphoinositide 3-kinase signaling in mast cells : new insights from knockout mouse studies"J Mol Med.. 81(9). 524-535 (2003)
[Publications] Suzuki R, Tobe K, Terauchi Y et al.: "Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner."J Biol Chem.. 278(44). 43691-43698 (2003)
[Publications] Kubota T et al.: "Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury."Circulation. 107(24). 3073-3080 (2003)
[Publications] Yamauchi T et al.: "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects"Nature. 423(6941). 762-769 (2003)
[Publications] Ogura T et al.: "Reduction of phosphodiesterase 3B gene expression in peroxisome proliferator-activated receptor gamma (+/-) mice independent of adipocyte size."FEES Lett. 542(1-3). 65-68 (2003)
[Publications] Terauchi Y et al.: "Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice."J Biol Chem. 278(16). 14284-14290 (2003)
[Publications] N.Itoh: "Fibroblast growth factor (FGF)"Encyclopaedia of Endocrine Diseases. (in press). (2004)
[Publications] 河野大輔, 藤原研, 前川文彦, 倉持素樹, 尾仲達史, 矢田俊彦: "視床下部・全身代謝・ストレスによる摂食調節"肥満研究. 9(3). 235-243 (2003)
[Publications] 斉藤昌之: "脳と栄養-行動の分子基盤を求めて-(斉藤昌之、鳥井邦夫、青山頼孝編集)"建帛社、東京. 59 (2003)
[Publications] 益崎裕章, 中尾一和: "Annual Review内分泌代謝"中外医学社. 6 (2004)

2003 Fiscal Year Annual Research Report

アディポミクス、脂肪細胞の機能世界と破綻病態の解明

Principal Investigator

松澤 佑次 大阪大学, 医学系研究科, 名誉教授 (70116101)

Research Products

[Publications] 木村和弘, 石岡克己 他: "犬と猫のレプチン-血中濃度の測定とその肥満評価への応用-"獣医畜産情報. 56. 43-46 (2003)

[Publications] 斉藤昌之: "エネルギー消費の自律的調節と肥満に関する分子栄養学的研究"日本栄養・食糧学会誌. 56. 33-39 (2003)

[Publications] Makondo, K., Kimura, K., Kitamura, N., Kitamura, T., Yamaji D., et al.: "Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca- and phosphoinsitide 3-kinase/Akt-dependent phosphorylation in aortic endothelial cells."Biochem.J.. 374. 63-69 (2003)

[Publications] 大橋敦子, 斉藤昌之: "共役脂肪酸の体脂肪低減効果とインスリン抵抗性・脂肪肝"胞満研究. 9. 128-135 (2003)

[Publications] Shibate, H., Sasaki, N.et al.: "Feline Leptin : Immunogenic and Biological Activities of the Recombinant Protein, and Its Measurement by ELISA."J.Vet.Med.Sci.. 65. 1207-1211 (2003)

[Publications] T.Asaki et al.: "Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo"Mol.Cell.Endocrinol.. in press. (2004)

[Publications] M.Affolter et al.: "Tube or not tube : remodelling epithelial tissues by branching morphogenesis"Dev.Cell. 4. 11-18 (2003)

[Publications] N.Kusu et al.: "Sclerostin is a novel secreted osteoblast-derived bone morhogenetic protein (BMP) antagonist with unique ligand specificity"J.Biol.Chem.. 278. 24113-24117 (2003)

[Publications] R.C.Burns et al.: "Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mice"Dev.Biol.. 265. 61-74 (2004)

[Publications] J.Laurikkala et al.: "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF and SHH signals from the tooth enamel knot"Dev.Biol.. 264. 91-105 (2003)

[Publications] S.Ohmachi et al.: "Peferential Neurotrophic Activity of Fibroblast Growth factor (FGF)-20 for Dopaminergic Neurons through FGF Receptor-1c"J.Neurosci.Res.. 72. 436-443 (2003)

[Publications] H.Masuzaki, J.S.Flier et al.: "Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice."J.Clin.Invest.. 112. 83-90 (2003)

[Publications] H.Masuzaki, J.S.Flier: "Tissue-specific glucocorticoid reactivating enzyme, 11□-hydroxy steroid dehydrogenase type 1(11□-HSD1). -A promising drug target for the treatment of the Metabolic Syndrome-"Curr.Drug Targets Immune Endocrinol.Metab.Disord.. 3. 249-256 (2003)

[Publications] A.Takahashi-Yasuno, H.Masuzaki (corresponding author)et al.: "Leptin receptor (Ob-R) Arg223Gln polymorphism is associated with serum cholesterol elevation and impairment of cholesterol lowering effect by simvastatin in Japanese men."Diabetes Res.Clin.Pract.. 62. 169-175 (2003)

[Publications] H.Shinyama, H.Masuzaki et al.: "Regulation of melanocortin-4 receptor signaling : Agonist-mediated desensitization and internalization."Endocrinology. 144. 1301-1314 (2003)

[Publications] N.M.Morton, H.Masuzaki, et al.: "Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11□-hydroxysteroid dehydrogenase type-1 deficient mice."Diabetes. in press. (2004)

[Publications] Iwaki M, Matsuda M, Maeda N, et al.: "Induction ofadiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors"Diabetes. 52(7). 1655-1663 (2003)

[Publications] Funahashi H, Yada T, Suzuki R, Shioda S: "Distribution, function, and properties of leptin receptors in the brain."Cytol(Int.Rev.). 224. 1-27 (2003)

[Publications] Nakata M, Yada T.: "Nitric Oxide-mediated insulin secretion in response to citrulline in islet b-cells"Pancreas. 27. 209-213 (2003)

[Publications] Rokkaku K, Onaka T, Okada N, Ideno J, Kawakami A, Honda K, Yada T, Ishibashi S: "Neuromedin U facilitates oxytocin release from the pituitary via beta adrenoceptors."Neuroreport. 14. 1997-2000 (2003)

[Publications] Kamada Y et al.: "Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin."Gastroenterology. 125(6). 1796-1807 (2003)

[Publications] Matsuzawa Y et al.: "Importance of adipocytokines in obesity-related diseases"Horm Res. 60. 56-59 (2003)

[Publications] Miyoshi Y et al.: "Association of serum adiponectin levels with breast cancer risk."Clin Cancer Res. 9(15). 5699-5704 (2003)

[Publications] Ouchi N et al.: "Obesity, adiponectin and vascular inflammatory disease."Curr Opin Lipidol. 14(6). 561-566 (2003)

[Publications] Nagasawa A et al.: "Divergent effects of soy protein diet on the expression of adipocytokines"Biochem Biophys Res Commun. 311(4). 909-914 (2003)

[Publications] Ouchi N et al.: "Association of hypoadiponectinemia with impaired vasoreactivity."Hypertension. 42(3). 231-234 (2003)

[Publications] Kishida K et al.: "Disturbed secretion of mutant adiponectin associated with the metabolic syndrome."Biochem Biophys Res Commun.. 306(1). 286-292 (2003)

[Publications] Kojima S et al.: "The variation of plasma concentrations of a novel, adipocyte derived protein, adiponectin, in patients with acute myocardial infarction."Heart. 89(6). 667 (2003)

[Publications] Zoccali C et al.: "Adiponectin is markedly increased in patients with nephrotic syndrome and is related to metabolic risk factors."Kidney Int Suppl. 84. S98-S102 (2003)

[Publications] Nagasawa A et al.: "Effects of soy protein diet on the expression of adipose genes and plasma adiponectin."Horm Metab Res. 34(11-12). 635-639 (2003)

[Publications] Ouchi N et al.: "Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue."Circulation. 107(5). 671-674 (2003)

[Publications] Kumada M et al.: "CAD Study Group. Coronary artery disease. Association of hypoadiponectinemia with coronary artery disease in men."Arterioscler Thromb Vase Biol.. 23(1). 85-89 (2003)

[Publications] Ouchi N et al.: "Association of hypoadiponectinemia with impaired vasoreactivity."Hypertension.. 42(3). 231-234 (2003)

[Publications] T.Nakagawa et al.: "Antiobesity and antidiabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance."Int.J.Obes.. 27. 557-565 (2003)

[Publications] K.Yamahara et al.: "Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration."Proc.Natl.Acad.Sci.USA. 100. 3404-3409 (2003)

[Publications] N.Satoh et al.: "Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect."Diabetes Care. 26. 2493-2499 (2003)

[Publications] F.Miyanaga et al.: "Leptin as an adjunct of insulin therapy in insulin-dependent diabetes."Diabetologia. 46. 1329-1337 (2003)

[Publications] A.Takahashi-Yasuno et al.: "Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men."Diabetes Res.Clin.Pract.. 62. 169-175 (2003)

[Publications] Kamei Y, et al.: "Identification of PPARγ coactivator 1β/ERR ligand 1 as an estrogen-related receptor protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity in mice."Proc.Natl.Acad.Sci.U.S.A.. 100. 12378-12383 (2003)

[Publications] Takahashi N, et al.: "Abietic acid activates peroxisome proliferator-activated receptor-γ(PPARγ)in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism."FEBS Lett.. 550. 190-194 (2003)

[Publications] Kim C.-S, et al.: "Macrophage inflammatory protein-related protein-2, a novel CC chemokine, can regulate preadipocyte migration and adipocyte differentiation."FEBS Lett.. 548. 125-130 (2003)

[Publications] Kamei Y, et al.: "A forkhead transcription factor FKHR up-regulates lipoprotein lipase expression in skeletal muscle"FEBS Lett.. 536. 232-236 (2003)

[Publications] Kim C.-S, et al.: "Capsaicin exhibits anti-inflammatory property by inhibiting IkB-α degradation in LPS-stimulated peritoneal macrophages."Cellular Signalling. 15. 299-306 (2003)

[Publications] Kageyama H, et al.: "Fasting increases gene expressions of uncoupling proteins and peroxisome proliferator-activated receptor-γ in brown adipose tissue of ventromedial hypothalamus-lesioned rats."Life Sciences. 72. 3035-3046 (2003)

[Publications] Mae T, et al.: "A licorice ethanolic extract with PPAR-γ ligand-binding activity affects diabetes in KK-Ay mice, abdominal obesity in diet-Induced obese C57BL mice and Hypertension in spontaneously hypertensive rats."J.Nutrition. 133. 3369-3377 (2003)

[Publications] Masuda Y, et al.: "Up-regulation of uncoupling proteins (UCPs) by oral administration of capsiate, a non-pungent capsaicin analog."J.Appl.Physiol.. 95. 2408-2415 (2003)

[Publications] Kuroda M, et al.: "Phenolics with PPAR-γ ligand-binding activity obtained from : Licorice (Glycyrrhiza uralensis roots ) and ameliorative effects of glycilin on genetically diabetic KK-A^y mice."Bioorg.Med.Chem.Lett.. 13. 4267-4272 (2003)

[Publications] Yu R, et al.: "Involvement of leukotactin-1, a novel CC chemokine, in human atherosclerosis."Atherosclerosi. In press. (2004)

[Publications] Tsuda T, et al.: "Anthocyanin enhances adipocytokine secretion and adipocyte specific gene expression in Isolated Rat adipocytes."Biochem.Biophys.Res.Commun. 316. 149-157 (2004)

[Publications] Inoue H et al.: "Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo."Nature Medicine. 10・2. 168-174 (2004)

[Publications] Sakaue H et al.: "Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes"Journal of Biological Chemistry. 278. 38870-38874 (2003)

[Publications] Matsumoto M et al.: "PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity."Journal of Clinical Investigation. 112・6. 935-944 (2003)

[Publications] Shimoaka T et al.: "Impairment of bone healing by insulin receptor substrate-1 deficiency."J Biol Chem.. Epub ahead of print. (2004)

[Publications] Fukao T, Terauchi Y, Kadowaki T, Koyasu S.: "Role of phosphoinositide 3-kinase signaling in mast cells : new insights from knockout mouse studies"J Mol Med.. 81(9). 524-535 (2003)

[Publications] Suzuki R, Tobe K, Terauchi Y et al.: "Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner."J Biol Chem.. 278(44). 43691-43698 (2003)

[Publications] Kubota T et al.: "Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury."Circulation. 107(24). 3073-3080 (2003)

[Publications] Yamauchi T et al.: "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects"Nature. 423(6941). 762-769 (2003)

[Publications] Ogura T et al.: "Reduction of phosphodiesterase 3B gene expression in peroxisome proliferator-activated receptor gamma (+/-) mice independent of adipocyte size."FEES Lett. 542(1-3). 65-68 (2003)

[Publications] Terauchi Y et al.: "Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice."J Biol Chem. 278(16). 14284-14290 (2003)

[Publications] N.Itoh: "Fibroblast growth factor (FGF)"Encyclopaedia of Endocrine Diseases. (in press). (2004)

[Publications] 河野大輔, 藤原研, 前川文彦, 倉持素樹, 尾仲達史, 矢田俊彦: "視床下部・全身代謝・ストレスによる摂食調節"肥満研究. 9(3). 235-243 (2003)

[Publications] 斉藤昌之: "脳と栄養-行動の分子基盤を求めて-(斉藤昌之、鳥井邦夫、青山頼孝 編集)"建帛社、東京. 59 (2003)

[Publications] 益崎 裕章, 中尾 一和: "Annual Review内分泌代謝"中外医学社. 6 (2004)

松澤佑次大阪大学, 医学系研究科, 名誉教授 (70116101)

[Publications] 木村和弘, 石岡克己他: "犬と猫のレプチン-血中濃度の測定とその肥満評価への応用-"獣医畜産情報. 56. 43-46 (2003)

[Publications] 斉藤昌之: "脳と栄養-行動の分子基盤を求めて-(斉藤昌之、鳥井邦夫、青山頼孝編集)"建帛社、東京. 59 (2003)

[Publications] 益崎裕章, 中尾一和: "Annual Review内分泌代謝"中外医学社. 6 (2004)