2007 Fiscal Year Final Research Report Summary
Study of IP3 receptor/Ca^<2+> signaling in neural plasticity and brain development and differentiation
Project/Area Number |
15100006
|
Research Category |
Grant-in-Aid for Scientific Research (S)
|
Allocation Type | Single-year Grants |
Research Field |
Neurochemistry/Neuropharmacology
|
Research Institution | The Institute of Physical and Chemical Research (2007) The University of Tokyo (2003-2006) |
Principal Investigator |
MIKOSHIBA Katsuhiko The Institute of Physical and Chemical Research, BSI, Group director (30051840)
|
Project Period (FY) |
2003 – 2007
|
Keywords | IP_3 receptor / Ca^<2+> signaling / neuronal plasticity / endoplasmic reticulum / redox sensor / Ip_ indicator / Na+K+-ATPase / 2-APB |
Research Abstract |
IP_3 is a second messenger to release Ca^<2+> from internal stores. We discovered that P400 which is deficient in Purkinje-neuron-degenerating mutant is IP_3 receptor (IP_3R). IP_3R /P400 is found to be localized on endoplasmic reticulum (ER). Purified IP_3 receptor (IP_3R) works as Ca^<2+> release channel and works as Ca^<2+> oscillator. IP_3R function is regulated by phosphorylation (by PKC, CaMK II, PKG) suggesting that IP_3R works as a cross-talk station between Ca^<2+> signaling and phosphorylation. IP_3R has unique properties: 1) IP_3R is functional even though it is fragmented by proteases into several pieces; 2) IP_3R allosterically and dynamically changes its form reversibly; _3) CryoEM study shows that IP_3R contains multiple cavities; 4) ER forms a meshwork and vesicular ER containing IP_3R moves rapidly along microtubles using kinesin motor. We succeeded in crystallization of IP_3 binding core and suppressor sequence. They show unique structure and interact each other to re
… More
cognize IP_3. Studies on the role of IP_3R during development show that IP_3R is involved in fertilization and is essential for determination of dorsoventral axis formation. IP_3R is involved in neuronal plasticity. Double homozygous mutant of IP_3R2 and IP_3R_3 shows deficit of exocrine secretion. ERp44 works as a redox sensor in the ER and regulates IP_3R1 activity. We developed IP_3 indicator (named as IRIS) using the IP_3 binding core. We discovered that IP_3 not only releases Ca^<2+>, but also releases IRBIT. IRBIT binds to the same site as IP_3. IRBIT works only when it is phosphorylated. It regulates frequency and amplitude of Ca^<2+> oscillation generated by IP_3R. In addition, phosphorylated IRBIT binds to pancreas type Na, Bicarbonate co-transporter 1 (NBC1) and works as a third messenger to enhance NBC1 which regulates pH inside cells. Therefore, signaling pathway may be modified to be as follows: [ extracellular signal →IP_3→IP_3R→Ca^<2+> release, and IRBIT release→NBC1 activation, and Ca^<2+> oscillation modification ]. Less
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[Journal Article] Optimization of Transfection Conditions for Gene Expression, siRNA Knock-Down, and Live Cell Imaging Using FuGENE(R) HD Transfection Reagent.2008
Author(s)
Kawaai K, Ishida S, Matsu-ura T, Kuroda Y, Ogawa N, Tashiro T, Enomoto M, Hisatsune C, Mikoshiba, K.
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[Journal Article] Activation of SAD Kinase by CA(2+) /Calmodulin-Dependent Protein Kinase Kinase.2008
Author(s)
Fujimoto T, Yurimoto S, Hatano N, Nozaki N, Sueyoshi N, Kameshita I, Mizutani A, Mikoshiba, K., Kobayashi R, Tokumitsu H.
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Journal Title
Briochemistry 47(13)
Pages: 4151-9
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase.2008
Author(s)
Ogawa M, Mizugishi K, Ishiguro A, Koyabu Y, Imai Y, Takahashi R, Mikoshiba, K., Aruga J.
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Journal Title
Genes Cells 13(4)
Pages: 397-409
Description
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[Journal Article] 「研究成果報告書概要(欧文)」より2008
Author(s)
Kabayama H, Tokushige N, Takeuchi M, Mikoshiba, K. Syntaxing 6 Regulates nerve growth Factor-dependent neurite outgrowth.
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Journal Title
Neurosci Lett. 436
Pages: 340-344
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[Journal Article] 2-Aminoethyl diphenyborinate analogues2007
Author(s)
Zhou, H., Iwasakai, H., Nakamura, T., Nakamura, K., Maruyama, T., Hamano, S., Ozaki, S., Mizutani, A., Mikoshiba., K.
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「研究成果報告書概要(欧文)」より
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[Journal Article] Up-regulated PAR-2-mediated salivary secretion in mice deficient in vuscarinic acetylcholine receptor subtypes.2007
Author(s)
Nishiyama, T., Nakamura, T., Obara, K., Inoue, H., Mishima, K., Matsumoto, N., Matsui, M., Manabe, T., Mikoshiba, K., Saito, I.
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Journal Title
J Pharmacolo Exp Ther. 320
Pages: 516-524
Description
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[Journal Article] A case of limited cutaneous systemic sclerosis developing anti-mitochondria antibody positiv primary biliary cirrhosis after acute myocardial infarction.2007
Author(s)
Miyachi, K., Hankins, R., Ihara, M., Miyamoto, A., Okano, T., Iwai, M., Mikoshiba, K., fritzler, MJ.
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Journal Title
Clin Rhecumatol. 26(9)
Pages: 1571-4
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Dvl regulates endo-and exocytotic processes through binding to synapotagmin.2007
Author(s)
Kishida, S., Hamao, K., Inoe, M., Hasegawa, M., Matsuura, Y., Mikoshiba, K., Fukuda, M., Kikuchi, A.
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Journal Title
Genes to Cells 12
Pages: 49-61
Description
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[Journal Article] Zic2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, Poly-ADP ribose polymerase, and RNA helicase A.2007
Author(s)
Ishiguro, A., Ideta, M., Mikoshiba, K., Chen, DJ., Aruga, J.
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Journal Title
J. Biol. Chem. 282(13)
Pages: 9983-9995
Description
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[Journal Article] Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras -transformed NIH/3T3 fibroblasts.2007
Author(s)
Hayashi, M., Fukuda, M., Nomura, H., Ito, N., Takahashi, H., Hattori, S., Mikoshiba, K., Noda, M., Higuchi, Y.
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Journal Title
Biochem Biophys Res Commun. 356(2)
Pages: 374-80
Description
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[Journal Article] Inositol 1, 4, 5-trisphosphate receptors are qutoantibody target antigens in patients with Sjogren's syndrome and other systemic rheumatic diseases.2007
Author(s)
Miyachi, K., Iwai, M., Asada, K., Saito, I. Hankins, R., Mikoshiba, K.
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Journal Title
Mod Rheumatol. 17(2)
Pages: 137-143
Description
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[Journal Article] The extremely conserved C-terminal region of reelin is not necessary for secretio but is required for efficient activation of donstream signaling.2007
Author(s)
Nakano, Y., T., Kohno, S., Baha, A., Mikoshiba, K., Nakajima, K. Hattori, M.
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Journal Title
J Biol Chem. 282(28)
Pages: 20544-52
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cdk5 is required for multipolar-tobipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex.2007
Author(s)
Ohashima, T., Hirosawa, M., Tabata, H., Mutoh, T., Adachi, T., Suzuki, H., Saruta, K., Iwasato, T., Itohara, S., Hashimoto, M., Nakajima., K., Ogawa, M., Kulkaruni, A. B., Mikoshiba, K
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Journal Title
Development 134(12)
Pages: 2273-2282
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Liganad-induced Conforrmational Changes via Flexible Linkers in the Amino-terminal region of the Inositol 1, 4, 5-Trisphosphate Receptor.2007
Author(s)
Chan J, Whitten AE, Jeffries CM, Bosanac I, Mal TK, Ito J, Porumb H, Michikawa T, Mikoshiba, Trewhella J, Ikura M
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Journal Title
J Mol Biol. 373(5)
Pages: 1269-80
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Abnormal Taste Perception in Mice Lacking the Type 3 Inositol 1, 4, 5-trisphosphate Receptor.2007
Author(s)
Hisatsune C, Yasumatsu K, Takahasi-Iwanaga H, Ogawa N, Kuroda Y, Yoshida R, Ninomiya Y, Mikoshiba, K.
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Journal Title
J Biol Chem 282(51)
Pages: 37225-37231
Description
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[Journal Article] Visuatization of inositol 1, 4, 5-trisphosphate receptor by atomic force microscopy.2006
Author(s)
Suhara, W., Kobayashi, M., Sagara, H., Hamada., K., Goto, T., Fujimoto, I., Torimitsu, K., Mikoshiba, K.
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Journal Title
Neuroscience Letters 391
Pages: 102-107
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Collaspsin response mediator protein 1 mediates reelin signaling in corical neuronal migration2006
Author(s)
Yamashita, N., Uchida, Y., Ohsima, T., Hirai, S., Nakamura, F., Taniguchi, M., Mikoshiba., K. Honnorat, J., Kolattukudy, P., Thomasset, N., Takei, K., Takahashi, T., Goshima, Y
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Journal Title
J. Neurosci. 26(51)
Pages: 13357-13362
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cytosolic inositol 1, 4, 5-trisphosphate dynamics during intracellular calcium oscillations in living cells.2006
Author(s)
Matsu-ura, T., Michikawa, T., Inoue, t., Miyawaki, A., Yoshida, M., Mikoshiba, K.
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Journal Title
J.Cell Biol. 173(5)
Pages: 755-765
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] IRBIT specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1, Pnbc1.2006
Author(s)
Shirakabe, K., Priori, G., Yamada, H., Ando, H., Horita, S., Fujita, T., Fujimoto, I., Mizutani, A., Seki, A., Mikoshiba, K.
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Journal Title
Proc. Natl. Acad. Sci. 103(25)
Pages: 9542-9547
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on IP3 receptor in a phosphorylatio-dependent manner.2006
Author(s)
Ando, H., Mizutani, A., Kiefer, H., Tsuzurugi, D., Michikawa, T., Mikoshiba., K.
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Journal Title
Molecular Cell 22
Pages: 795-806
Description
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[Journal Article] Neurogenic potential of progenitors derived from human circulating CD14+ monocytes.2006
Author(s)
Kodama, H., Inoue, T., Watanabe, R., Yasutomi, D., Kawakami, Y., Ogawa, S., Mikoshiba., K., Ikeda, Y., Kuwana, M.
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Journal Title
Immunology and Cell Biol. 84
Pages: 209-217
Description
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[Journal Article] Distinct role of the N-terminal tail of the Na, K-ATPase Catalytic subunit as a signal transducer.2006
Author(s)
Zhang, S., Malmersjo, S., Li, J., Ando, H., Aizman, O., Uhlen, P., Mikoshiba, K., Aperia, A.
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Journal Title
J. Biol. Chem. 281
Pages: 21954-21962
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[Journal Article] ATP autocrine/paracrine signaling induces calcium oscillations and EFAT activation in human mesenchymal stem cells.2006
Author(s)
Kawano, S., Otsu, K., A., Shoji, S., Yanagida, E., Muto, Y., Yoshikawa, F., Hirayama, Y., Mikoshiba., K., Furuichi, T.
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Journal Title
Cell Calcium 39
Pages: 313-324
Description
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[Journal Article] Homer 1 mediates store-and inositol 1, 4, 5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane.2006
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Kim J. Y., Zen W., Kiselyov K., Yuan J. Y., Dehoff M. H., Mikoshiba., K., Worely P. F., Muallem S.
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J. Biol. Chem. 281
Pages: 32540-32549
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[Journal Article] Decreased Basal mucus secretion by Slp2-a-deficient gastric surface mucous cells.2006
Author(s)
Saegusa, C., Tanaka, T., Tani, S., Itohara, S., Mikoshiba, K. Fukuda, M.
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Journal Title
Genes to Cells 21
Pages: 623-631
Description
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[Journal Article] Phosphory lation of the tubulin -binding protein, stathmin, by Cdk5 and MAP Kinascs in the brain.2006
Author(s)
Hayashi, K., Pan, Y., Shu, H., Ohshima, T., Kansy, J. W., White, C. L., Tamminga, C. A., Sobel, A., Curmi, P. A., Mikoshiba, K., Bibb, P. A.
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J. Neurochem. 99
Pages: 237-250
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[Journal Article] Inositol 1, 4, 5-trisphoaphate receptor type 1 in granule cells, not in Purkinje cells, regulates the dendritic morphology of Purkinje cells throu gh BDNF production.2006
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Hisatsune, C., Kuroda, Y., Akagi, T., torashima, T., Hirai, H., Hashikawa, T., Inoue, T., Mikoshiba, K.
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J. Neurosci. 26(42)
Pages: 10916-10924
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[Journal Article] Organelles containing inositol trisphosphate receptor type 2 in adrenal medullary cells.2006
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Endo, Y., Harada, K., Fujishiro, N., Funahashi, H., Shioda, S., Prestwich, G.D., Mikoshiba., K., Inoue, M.
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J. Physiol. Sci. 56(6)
Pages: 415-423
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「研究成果報告書概要(欧文)」より
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[Journal Article] A wide-range phyolgenetic analysis of Zic proteins2006
Author(s)
Aruga, J., Kamiya, A., Takahashi H., fujimi, T.J., Shimizu, Y. Ohakawa, K., Yazawa, S., Umesono, Y. Noguchi, H., Shimizu, T., Saitou, N., Mikoshiba, K., Sakaki, Y, Agata, K, Toyoda, A.
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Journal Title
Genomics. 87(6)
Pages: 783-792
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Collaspsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration.2006
Author(s)
Yamashita, N., Uchida, Y., Ohshima, T., Hirai, S., Nakanura, F., Taniguchi, M., Mikoshiba, K., Honnorat, J., Kolatukudy, P., Thomasset, N., Takei, K., Takahashi, T., Goshima Y.
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Journal Title
J. Neurosci. 26(510
Pages: 13357-13362
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Subtype-specific and ER-lumenal-evironment=dependent Regulation of Inositol 1, 4, 5-Trisphosphate Receptor Type 1 by ERp44.2005
Author(s)
Higo, T., Hattori, M., Nakamura, T., Natsume, T., Michikawa, T, Mikoshiba. K
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Journal Title
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「研究成果報告書概要(欧文)」より
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[Journal Article] Molecular cloning of mouse type-2 an type-3 inositol 1, 4, 5-trisphosphate receptors and identification of anovel type-2 receptor splice variant.2005
Author(s)
Iwai, M., Tateishi, Y., Hattori, M., Mizutani, A., Nakamura, T., Futatsugi, A., Inoue, T., furuichi, T., Michikawa, T., Mikoshiba., K.
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Journal Title
J. Biol. Chem. 280
Pages: 10305-10317
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cluster formation of in ositol 1, 4, 5-trisphosphate receptor requires its transition to open state.2005
Author(s)
Tateishi, Y., Hattori, M., Nakayama, T., Iwai, M., Bannai, H., Nakamura, T., T maichikawa, T., Inoue, T., Mikoshiba, K.
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Journal Title
J. Biol. Chem 280
Pages: 6816-6822
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「研究成果報告書概要(欧文)」より
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[Journal Article] Crystal structure of the ligand binding suppressor domain of type 1 inositol 1, 4, 5-trisphosphate receptor.2005
Author(s)
Bosanac, I., Yamazaki, H., Matsu-ura, T., Michikawa, T., Mikoshiba, K., Ikura, M
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Journal Title
Molecular Cell 17
Pages: 193-203
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Semaphorin 3A signaling is mediated via sequential Cdk5 and GSK3 β phosphorylation of CRMP2 : implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease.2005
Author(s)
Uchida, Y., Ohsima, T., Sasaki, Y., Suzuki, H., Yanai, S., yamashita., N., Nakamura, F., Takei, K., Ihara, Y., Mikoshiba., K., Kolattukudy, P., Honnorat, J., Goshima, Y
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Journal Title
Genes to Cells 10
Pages: 165-179
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Amplification of Ca2+ Singnalingby Diacyglycerol-mediated Inositol 1, 4, 5-Trisphosphate Production.2005
Author(s)
Hisatsune, C., Nakamura, K., Kuroda, Y., Nakamura, T. Mikoshiba, K.
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J. Biol. Chem. 280 12
Pages: 11723-11730
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Control of cyclin-dependent kinase 5(Cdk) 5activity by glutamatergic regulation of p35 stability.2005
Author(s)
Wei, F.-Y., Tomizawa, K., Ohshima, T., Asada, A., Saito, T., Nguye, C., Bibb, J. A., Ishiguro, K., Kulkarni, A. B., Pant, H. C., Mikoshiba, K., Matsui, H., Hisanaga, S.
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Journal Title
J. Neurochem. 93
Pages: 502-512
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「研究成果報告書概要(欧文)」より
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[Journal Article] Impainment of hippocampal long-term depression and defective spatial learning and memory in p35-/- mice.2005
Author(s)
Oshima, T., Ogura, H., Hayashi, K., Suzuki, H., Saito, T., Kamei, H., Nishi, A., James, A. B., Hisanaga, S., Matsui, H., Mikoshiba., K.
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J. Nenrochem. 94
Pages: 917-925
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「研究成果報告書概要(欧文)」より
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[Journal Article] Cdk5-dependent regulation of glucouse-stimulates insulin secretion.2005
Author(s)
Fan-Yan Wei, Nagashima, K., Oshima, T., Saheki, Y., Matsushita, M., Yamada, Y., Mioshiba., K., Seino, Y., Tomozawa, K.
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Journal Title
Nature Medicine 11(10)
Pages: 1104-1108
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] IP3 Receptor Types 2 and 3 mediate exocrine secretion underlying energy metabolism.2005
Author(s)
Futatsugi, A., Nakamura, T., Yamada, M. K., Ebisui, E., Nakamura, K., Uchida, K., Kitaguchi, T., Takahashi-Iwanaga, H., Noda, T., Aruga, J., Mikoshiba., K.
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Journal Title
Science 309
Pages: 2232-2234
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Involvement of IP3 receptors in LTP and LTD in duction in guinea pig hippocampla CAI neurons.2005
Author(s)
Taufiq, A., M., Fujii, S., Yamazaki, Y., Sakasi, H., Kaneko, K., Li, J., Kato, H., Mikoshiba, K.
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Journal Title
Learning & Memory
Pages: 594-600
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cardiomyogenic Potential of Mesenchymal progenitors derived from human circulating CD14+ Monocytes.2005
Author(s)
Komada, H., Inoue, T., Watanabe, R., Yasuoka, H., Kawakami, Y., Ogawa, S., Mikoshiba, K., Kuwana, M.
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Journal Title
Stem Cells and Development 14
Pages: 676-686
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Targeted expression of IP3 sponge and IP3 DSRNA impaires sugar taste sensation in drosophila.2005
Author(s)
Usui-Aoki, K., Matsumoto, K., Koganezawa, M., Kohatsu, S., Isono, K., Matsubayashi, H., Yamamoto, M., Ueda, R., Takahashi, K., Saigo, K., Mikoshiba., K., Yamamoto, D
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Journal Title
J. Neurogenetics 19
Pages: 123-141
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The secretory granule-associated protein CAPS2 REGULATES NEUROTROPHIN RELEASE AND CELL SURVIVAL.2004
Author(s)
Sadakata, T., Mizoguchi, A., Sato, Y., Katoh-Semba, R., Fukuda, M., Mikoshiba.K., Furuichi, T
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Journal Title
J, Neurosci. 24(1)
Pages: 43-52
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Distinct roles of inositol 1, 4, 5-trisphosphate receptor types 1 and 3in Ca2+ signaling.2004
Author(s)
Hattori, M, Suzuki, A. Z., Higo, T., Miyauchi, H., Michikawa, T., Nakamura, T. Inoue, T.and Mikoshiba, K
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Journal Title
J. Biol. Chem. 279
Pages: 11967-11975
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Kinesin dependent, rapid, bidirectional transport of ER sub-compartment in dendrites of neurous.2004
Author(s)
Bannai, H., Inoue, T., Nakamura, T., Hattor, Mikoshiba, K
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Journal Title
J. Cell Sci. 117
Pages: 163-175
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The regulatory domain of the inositol 1, 4, 5-trisphosphate receptor is necessary to maintain the channel domain closed-Possible Physiological significance of specific cleavage by caspase-3.2004
Author(s)
Nakayama, T., Hattori, M., Uchida, K., Nakamura, T., Tateishi, Y., Bannai, H., Iwai, M., Michikawa, T., Inoue T., Mikoshiba, K
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Journal Title
Biochem. J. 377
Pages: 299-307
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A chemical LTP induced by co-activaton of metabotropic and N-methyl-D-aspartate glutamate receptors in hippocampal CAI neurons.2004
Author(s)
Fujii, s., Sasaki, H., Mikoshiba., K., Kuroda, Y., Yamazaki, Y., Taufiq, A. M., Kato, H
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Journal Title
Brain Research 999
Pages: 20-28
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Inositol 1, 4, 5-trisphosphate Receptor contains Multiple cavities and L-shaped Ligand -binding domains.2004
Author(s)
Sato, C., Hamada, K., Ogura, T., Miyazawa, A., Iwasaki, K., Hiroaki, Y., Tani, K., Terauchi, A., Fujiyoshi, Y., Mikoshiba, K
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Journal Title
J. Mol. Biol. 336
Pages: 155-164
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Immunocytochemical localization of the α 1A subunit of the P/Q-type calcium channel in the rat cerebellum.2004
Author(s)
Kulik, A., Nakadate, K., Hagiwara, A., Fukazawa, Y., Saito, H., Suzuki, N., Futatsugi, A., Mikoshiba., K., Frotscher. M., Shigemoto, R.
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Journal Title
Europan Journal of Neuroscience vol. 19
Pages: 2169-2178
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The N-terminal Ca^<2+> -independent Calmodulin-binding site on the Inositol 1, 4, 5-trisphosphare receptor is responsible for Calmodulin inhibition, even though this in hibition reqires Ca^<2+>.2004
Author(s)
Nadif Kasri, N., bultynck, G., Smyth., J., Szlufcik, K., Parys, J.B., Callewaert, G., Missiaen, L., Fissore, R.A., Mikoshiba. K., De Smedt, H.
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Journal Title
Molecular Pharmacology 66
Pages: 276-284
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] M3 muscarinic acetylcholine receptor plays critical role in parasympathetic control of salivation in mice.2004
Author(s)
Nakamura, T., Matsui, M., Uchida, K., Futatsugi, A., Kusakawa, S., Matsumoto, N., Nakamura, K., Manabe, T., Taketo, M.M., Mikoshiba, K
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Journal Title
J. Physiol. 558
Pages: 561-575
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Activity-dependent expression of inositol 1, 4, 5-trisphosphate receptor type lin hippocampal neurons.2004
Author(s)
Cai, W., Hisatsune, C., Nakamura, K., Nakamura, T., Inoue, T., Mikoshiba, K.
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Journal Title
J. Biol. Chem. 279(22)
Pages: 23691-23698
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Regulation of TRPC6 channel activity by tyrosine phosphorylation.2004
Author(s)
Hisatsune, C., Kuroda, Y., Nakamura, K., Inoue, T., Nakamura, T., Michikawa, T., Mizutani, A., Mikoshiba, K.
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Journal Title
J. Biol. Chem. 279(18)
Pages: 18887-18894
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Junctate is a key element in calcium entry in duced by activation of Insp3 receptors and/or calcium store depletion.2004
Author(s)
Treves, S., franzini-Armsturong, C., Moccagatta, L., Amoult, C., Grasso, C., Schrum, A., Dureux, S., Zhu, M. X., Mikoshiba, K., Girard, T., Smida-Rezgui, S., Ronjat, M., Zorzato, F.
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Journal Title
J. Cell Biol. 166(4)
Pages: 537-548
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] 2-Aminocthoxydiphenyl borate inhibits against-induced Ca2+ signals by inositol trisphosphatce formation in acutely dissociated mouse pancreqtic acinar cells.2004
Author(s)
Wu, J., Takeo, T., Suga, S., Kanno, T., Osanai, T., Mikoshiba, K., Wakui, M
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Journal Title
Cell and Molecular Physiogy 448
Pages: 592-595
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Regulation of actin cytoskeleton by mDabl through N-WASP and ubiquitination of mDabl.2004
Author(s)
Suetsugu, S., Tezuka, T., Morimura, T., Hattori, M., Mikshiba, K., Yamamoto, T., Takenawa, T
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Journal Title
Biochem. J. 384
Pages: 1-8
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] An RNA-interacting Protein, SYNCRIP(Heterogeneous Nuclear Ribonuclear Protein Q1/NSAP1) Is a Component of mRNA Granule Transporlted with Inositol 1, 4, 5-Trisphosphate Receptor Type 1 mRNA in Newronal Dendrites.2004
Author(s)
Bannai, H., Fukatsu, K., Mizutani, A, Natsume, T., Iemura, S., Ikegami, T., Inoue, T., Mikoshiba, K.
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Journal Title
J. Biol. Chem 279(51)
Pages: 53427-53434
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Lateral diffusion of inositol 1, 4, 5-trisphosphate recepter type I is regulated actin Filaments and. In in neuronal dendrites.2004
Author(s)
Fukatsu, K., Bannai, K., Zhang, S., Nakamura, H., Inoue, T., Mikoshiba, K
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Journal Title
J. Biol. Chem. 279
Pages: 48976-48982
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects.2004
Author(s)
Hirasawa, M., Ohsima, T., Takahashi, S., Longenecker, G., Honjo, Y., Veeranna, Pant, H. C., Mikoshiba, K., Brady, R. O., Kulkarni, A. B.
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Journal Title
Proc. Natl. Acad. Sci. 101(16)
Pages: 6249-6254
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Protein 4. 1N is required for translocation fo inositol 1, 4, 5-trisphosphate receptor type l to the basolateral membrane domain in polarized madin-darby canine kidey cells2003
Author(s)
Zhang, S., Mizutani, A., Hisatsune, C., Higo, T., Bannai, H., Nakayama, T., Hattori, M., Mikoshiba, K
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Journal Title
J. Biol. Chem. 278(6)
Pages: 10602-10612
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] IRBIT, a novel inositol 1, 4, 5-trisphosphate(IP3) receptor binding protein, is released from the IP3 receptor upon IP3 binding to the receptor.2003
Author(s)
Ando, H., Mizutani, A., Matsu-ura, T., Mikoshiba, K
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Journal Title
J. Biol. Chem. 278
Pages: 10602-10612
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Imaging of calcineurin activated by long -term depression-inducing synaptic inputs in living neurons of rat visual corlex.2003
Author(s)
Yasuda, H., Higashi, H., Kudo, Y., Inoue, T., Hata, Y., Mikoshiba, K., Tsumoto, T
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Journal Title
European J. of Neuroscience 17
Pages: 287-297
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Inhibition of ubiquitin ligase Siah-1A by disabled-l.2003
Author(s)
Park, T., -J., Hamanaka, H., Ohsima, T., Watanabe, N., Mikoshiba, K., Nukina, N
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Journal Title
Biochem. Biophys. Res. Commun. 302
Pages: 671-678
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Long-term potentiation and long-term depression in hippocampal CAI neurons of mice lacking the IP3 type l receptor.2003
Author(s)
Nagase, T., Ito, K. -I., Kato, K., Kaneko, K., Kohda, K., Matsumoto, M., Hoshino, A., Inoue, T., Fujii, S., Kato, H., Mikoshiba, K.
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Journal Title
Neuroscience 117
Pages: 821-830
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Phospholipase Co 4 is required for ca2+ mobilization essential for acrosome reaction in sperm.2003
Author(s)
Fukami, K., Yoshida M., Inoue, T., Kurosawa, M., Rafael A.F., Yoshida, N., Mikoshiba, K., Takenawa, T
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Journal Title
J. Cell Biology 161
Pages: 79-88
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Critical regions for activation gating or the inositol 1, 4, 5-Trisphosphate receptor2003
Author(s)
Uchida, K., Miyauchi, H., Furuichi, T., Michikawa, T., Mikoshiba. K
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Journal Title
J. Biol. Chem. 278(19)
Pages: 16551-16560
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Zic2 pattems binocular vision by specifying the uncrossed retinal projection.2003
Author(s)
Herrera, E., Brown, L., Aruga, J., Rachel, R. A., Dolen, G., Mikoshiba, K., Brown, S., Mason, C.A
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cell signaling microdomain with Na, K-ATPase and inositol 1, 4, 5-trisphate recepter generates calucim oscillations.2003
Author(s)
Miyakawa-Naitou, A., Uhlen, P., Lal, M., Aizma, O,. Mikoshiba, K., Brismar, H., Zelenin, S., Aperia, A
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Journal Title
J. Biol. Chem. 278(50)
Pages: 50355-50361
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Reelin and Disabled-l expression in developing and mature human cortical neurons.2003
Author(s)
Deguchi, K., Inoue, K., Avila, W. E., L. -Terrada, D., Antalffy, B. A., Quattrocchi, C. C., Sheldon, M., Mikoshiba. K., D'Arcangelo, G., Armstong. D. L.
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Journal Title
J. Neuropathol. Exp.Neurol. 62(6)
Pages: 676-684
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Structure and function of IP3 receptor and its role in cell function 20th Bienniol2005
Author(s)
Mikoshiba K, Michikawa T, Hamada K, Ando H, Higo T, Nakamura T, Futatsugi A, Fukatsu K, Kuruma A, Goto J, Inoue T, Mizutani A
Organizer
Meeting of the International Society for Neurochemistry(ISN) and the European Society for Neurochemistry(ESN), (invited symposium lecture) Innsbruck
Place of Presentation
Austria
Year and Date
20050800
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Ca^<2+> signaling in development and cell function.2004
Author(s)
Mikoshiba K, Michikawa T, Hamad K, Ando H, Higo T, Fujimoto I, Nakamura T, Bannai H, Fukatsu K, Inoue T
Organizer
Calcium function in Development, Health and Disease : Applications in Biotechonology
Place of Presentation
Hong Kong China
Year and Date
20041100-1200
Description
「研究成果報告書概要(欧文)」より
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[Presentation] IP3 receptor/calcium channel : its structure and the role in cell function. Korea-Japan, invited2004
Author(s)
Mikoshiba K, Michikawa T, Hamad K, Ando H, Higo T, Fujimoto I, Nakamura T, Bannai H, Fukatsu K, Inoue T.
Organizer
Frontiers in Epithelial Transport The 3rd Symposium on Exocrine Glands symposium lecture)
Place of Presentation
Seoul Korea
Year and Date
20040700
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 神経の発生2003
Author(s)
御子柴 克彦
Organizer
第26回日本医学会総会
Place of Presentation
福岡
Year and Date
20030400
Description
「研究成果報告書概要(和文)」より
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