Applying ferrite nanobeads to medical diagnosis, therapy and analysis

2005 Fiscal Year Final Research Report Summary

• Project/Area Number: 15209019
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: ABE Masanori Tokyo Institute of Technology, Department of Physical Electronics, Professor, 大学院・理工学研究科, 教授 (70016624)
• Co-Investigator(Kenkyū-buntansha): HANDA Hiroshi Tokyo Institute of Technology, Department of Biologiral Information Science, Professor, 大学院・生命理工学研究科, 教授 (80107432) ; HIBI Norifumi Keio University, Department of Internal Medicine, Professor, 医学部, 教授 (50129623)
• Project Period (FY): 2003 – 2005
• Keywords: Magnetic beads / Bio-screening / Bio-sensing / MRI contrast agent / Hyperthermia / Anticancer drug / DNA / Ferrite nanobeads

Research Abstract

1. Development of size controlled ferrite nanobeads
Iron-ferrite nanoparticles with controlled size of 10-100 nm were successfully synthesized by our newly developed methods called co-precipitation, partial-oxidation, and seed-growth methods.
2. Development of functional-polymer coated ferrite nanobeads
The iron-ferrite nanoparticles were successfully coated with poly-GMA, which exhibits minimal non-specific adsorption of proteins, by a co-polymerization method and a novel, soap-free polymerization method.
3. Development of polymer coated iron nanobeads
Metallic iron nanoparticles (7-20 nm in size), which have magnetization two times stronger than that of ferrite particles and are advantageous for magnetic separation in bio-screening, were successfully coated with poly-GMA.
4. Application to analysis by bio-screening system
The poly-GMA coated ferrite nanobeads were conjugated with physiologically active substances such as anticancer antibodies and recombinant proteins containing tagged Prote in-G. Utilizing the beads, we successfully captured physiologically active substances that are complementary to those conjugated onto the beads. This revealed our beads are fitted for magnetic carriers for high throughput bio-screening.
5. Application to diagnosis by Hall bio-sensing
poly-GMA coated ferrite nanobeads were conjugated with single strand DNA, which were immobilized onto the surface of a Hall sensor via hybridization with the complementary DNA single strand fixed on the sensor surface. This revealed our beads are applicable to magnetic carriers for DNA analysis.
6. Application to diagnosis by contrast enhanced MRI
We successfully modified the surfaces of the ferrite nanobeads with a variety of functional molecules, and discovered candidate materials for high performance MRI contrast agent.
7. Application to anticancer magnetic hyperthermia
Utilizing the ferrite nanobeads as heat source by magnetic-field induction at an non-invasive frequency of 120 kHz, we successfully killed human colon cancer cells. We thus revealed that our beads are applicable to magnetic carriers for non-invasive, anticancer magnetic hyperthermia.

Research Products

• [Journal Article] The VP2/VP3 minor capsid protein of SV40 promotes the in vitro assembly of the major capsid protein VP1 into particles (2006)
  • Author(s): Kawano, M., Inoue, T., Tsukamoto, H., Takaya, T., Enomoto, T., Takahashi, R.U., Yokoyama, N., Yamamoto, N., Nakanishi, A., Imai, T., Wada, T., Kataoka, K., Handa, H.
  • Journal Title: J. Biol. Chem. 281 Pages: 10164-10173
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Glucose oxidase assisted homogeneous electrochemical receptor binding assay for drug screening (2006)
  • Author(s): Funabashi, H., Tanaka, Y., Imamura, Y., Mie, M., Manabe, T., Tanaka, H., Takahashi, Takashi, Handa, H., Aizawa, M., Kobatake, E.
  • Journal Title: Biosens Bioelectron. 21 Pages: 1675-1683
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The VP2/VP3 minor capsid ptotein of SV40 promotes the in vitro assembly of the major capsid protein VP1 into particles. (2006)
  • Author(s): Kawano, M., Inoue, T., Tsukamoto, H., Takaya, T., Enomoto, T., Takahashi, R.U., Yokoyama, N., Yamamoto, N., Nakanishi, A., Imai, T., Wada, T., Kataoka, K., Handa, H.
  • Journal Title: J.Biol.Chem. 281 Pages: 10164-10173
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Glucose oxidase assisted homogeneous electrochemical receptor binding assay for drug screening (2006)
  • Author(s): Funabashi, H., Tanaka, Y., Imamura, Y, Mie.M., Manabe, T., Tanaka, H., Takahashi, Takashi., Handa, H., Aizawa, M., Kobatake, E.
  • Journal Title: Biosens Bioelectron. 21 Pages: 1675-1683
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 医用磁性ナノビーズの新しい作製技術 (2005)
  • Author(s): 阿部, 正紀, 半田, 宏
  • Journal Title: 応用物理 74・12 Pages: 1580-1583
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Novel Medical Ferrite Nanobeads with Bioactive Molecules Immobilized Strongly onto the Surfaces (2005)
  • Author(s): Abe, M., Matsushita, N., Shimazu, R., Tada, M., Gokon, N., Nishio, K., Handa, H.
  • Journal Title: Mater. Res. Soc. Symp. Proc. 877E Pages: S8-2
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Functionalization of Micro-Hall Effect Sensors for Biomedical Applications Utilizing Superparamagnetic Beads (2005)
  • Author(s): A.Lapicki, H.Sanbonsugi, T.Yamamura, N.Matsushita, M.Abe, H.Narimatsu, H.Handa, A.Sandhu
  • Journal Title: IEEE Trans. Magn. Soc. 41, 10 Pages: 4134-4136
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] FMR Study on Spin-Sprayed Ni-Zn-Co Ferrite Films with High Permeability Usable for GHz Noise Suppressors (2005)
  • Author(s): K.Kondo, T.Chiba, S.Yoshida, S.Okamoto, Y.Shimada, N.Matsushita, A.Abe
  • Journal Title: IEEE Trans. Magn. Soc 41, 10 Pages: 3463-3465
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expediting Magnetic Separation Using Ni Wires, Applicable for Robot-Manipulated Bio-Screening systems (2005)
  • Author(s): Shimazu, R., Tada, M., Matsushita, N., Handa, H., Abe, M.
  • Journal Title: IEEE Trans. Magn. Soc. 41, 10 Pages: 4117-4119
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Styrene-Coated Iron Nanobeads for Medical Use (2005)
  • Author(s): Kuroda, C.S., Maeda, M., Nishibiraki, H., Matsushita, N., Handa, H., Abe, M.
  • Journal Title: IEEE Trans. Magn. Soc. 41, 10 Pages: 4143-4145
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Preparlation of medical magnetic nanobeads with ferrite particles encapsulated in a polyglycidyl methacrylate (GMA) for bioscreening (2005)
  • Author(s): Nishibiraki, H., Kuroda, C.S., Maeda, M., Matsushita, N., Abe, M., Handa, H.
  • Journal Title: JOURNAL OF APPLIED PHYSICS 97 Pages: 10Q919,1-3
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Functionalization of Micro-Hall Effect Sensors for Biomedical Applications Utilizing Superparamagnetic Beads (2005)
  • Author(s): Adam LAPICKI, Hideaki SANBONSUGI, Takuya YAMAMURA, Nobuhiro MATSUSHITA, Masanori ABE, Hiroki NARIMATSU, Hiroshi HANDA, Adarsh SANDHU
  • Journal Title: IEEE Trans. Magn. Soc 41, 10 Pages: 4134-4136
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Affinity Identification of o Opioid Receptors Using Latex Nanoparticles (2005)
  • Author(s): Hasegawa, M., Ohno, H., Tanaka, H., Hatakeyama, M., Kawaguchi, H., Takahashi, T., Handa, H.
  • Journal Title: Bioorg. Med. Chem. Lett. 16 Pages: 158-161
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Development of polymer latex particles for selctive cleavage of mismatched DNA and their application for DNA diagnosis. (2005)
  • Author(s): Oba, S., Hatakeyama, M., Handa, H., Kawaguchi, H.
  • Journal Title: Bioconjugate Chemistry 16 Pages: 551-558
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Polymer coating of ferrite nanoparticles by using "connecter" chemical compounds. (2005)
  • Author(s): Tsubouchi, S., Nishio, K., Ikeda, M., Narimatsu, H., Gokon, N., Handa, H., Abe, M.
  • Journal Title: Proceedings of the Ninth International Conference on Ferrites (ICF-9) Pages: 499-454
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Selective ligand purification using high-performance affinity beads. (2005)
  • Author(s): Ohtsu, Y., Ohba, R., Imamura, Y., Kobayashi, M., Hatori, H., Zenkoh, T., Hatakeyama, M., Manabe, T., Hino, M., Yamaguchi, Y., Kataoka, K., Kawaguchi, H., Watanabe, H., Handa, H.
  • Journal Title: Anal. Biochem. 338 Pages: 245-252
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Abnormally differentiated subsets of intestinal macrophage play a key role in Thl-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria. (2005)
  • Author(s): Kamada N., Hisamatsu T., Okamoto S., Sato T., Matsuoka K., Arai K., Nakai T., Hasegawa A., Inoue N., Watanabe N., Akagawa KS., Hibi T.
  • Journal Title: J Immunol 175 Pages: 6900-6908
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response. (2005)
  • Author(s): Sato T, Nakai T, Tamura N, Okamoto S., Matsuoka K, Sakuraba A., Fukushima T, Uede T., Hibi T
  • Journal Title: Gut 54 Pages: 1254-62
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Novel Medical Ferrite Nanobeads with Bioactive Molecules Immobilized Strongly onto the Surfaces (2005)
  • Author(s): Abe, M., Matsushita, N., Shimazu, R., Tada, M., Gokon, N., Nishio, K., Handa, H.
  • Journal Title: Mater.Res.Soc.Symp.Proc. 877E Pages: S8-2
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functionalization of Micro-Hall Effect Sensors for Biomedical Applications Utilizing Superparamagnetic Beads (2005)
  • Author(s): A.Lapicki, H.Sanbonsugi, T.Yamamura, N.Matsushita, M.Abe, H.Narimatsu, H.Handa, A.Sandhu
  • Journal Title: IEEE Trans.Magn.Soc. 41,10 Pages: 4134-4136
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] FMR Study on Spin-Sprayed Ni-Zn-Co Ferrite Films with High Permeability Usable for GHz Noise Suppressors (2005)
  • Author(s): K.Kondo, T.Chiba, S.Yoshida, S.Okamoto, Y.Shimada, N.Matsushita, M.Abe
  • Journal Title: IEEE Trans.Magn.Soc. 41,10 Pages: 3463-3465
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expediting Magnetic Separation Using Ni Wires, Applicable for Robot-Manipulated Bio-Screening Systems (2005)
  • Author(s): Shimazu, R., Tada, M., Matsushita, N., Handa, H., Abe, M.
  • Journal Title: IEEE Trans.Magn.Soc. 41,10 Pages: 4117-4119
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Styrene-Coated Iron Nanobeads for Medical Use (2005)
  • Author(s): Kuroda, C.S., Maeda, M., Nishibiraki, H., Matsushita, N., Handa, H., Abe, M.
  • Journal Title: IEEE Trans.Magn.Soc. 41,10 Pages: 4143-4145
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] High-Sensitivity InSb Thin-Film Micro-Hall Sensor Arrays for Simultaneous Multiple Detection of Magnetic Beads for Biomedical Applications (2005)
  • Author(s): Kiyoshi Togawa, Hideaki Sanbonsugi, Adam Lapicki, Masanori Abe, Hiroshi Handa, Adarsh Sandhu
  • Journal Title: IEEE Trans.Magn.Soc. 41,10 Pages: 3661-3663
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Preparlation of medical magnetic nanobeads with ferrite particles encapsulated in a polyglycidyl methacrylate (GMA) for bioscreening (2005)
  • Author(s): Nishibiraki, H., Kuroda, C.S., Maeda, M., Matsushita, N., Abe, M., Handa, H.
  • Journal Title: JOURNAL OF APPLIED PHYSICS 97,10Q919 Pages: 1-3
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functionalization of Micro-Hall Effect Sensors for Biomedical Applications Utilizing Supernaramarnetic Beads (2005)
  • Author(s): Adam LAPICKI, Hideaki SANBONSUGI, Takuya YAMAMURA, Nobuhiro MATSUSHITA, Masanori ABE, Hiroki NARIMATSU, Hiroshi HANDA, Adarsh SANDHU
  • Journal Title: IEEE Trans.Magn.Soc. 41,10 Pages: 4134-4136
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Practical Hall Sensors for Biomedical Instrumentation (2005)
  • Author(s): Sandhu, A., Handa.H.
  • Journal Title: IEEE Trans Magn 41 Pages: 4123-4127
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Affinity Identification of δ Opioid Receptors Using Latex Nanoparticles (2005)
  • Author(s): Hasegawa, M., Ohno, H., Tanaka, H., Hatakeyama, M., Kawaguchi, H., Takahashi, T., Handa, H
  • Journal Title: Bioorg.Med.Chem.Lett. 16 Pages: 158-161
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of polymer latex particles for selctive cleavage of mismatched DNA and their application for DNA diagnosis. (2005)
  • Author(s): Oba, S., Hatakeyama, M., Handa, H, Kawaguchi, H.
  • Journal Title: Bioconjugate Chemistry 16 Pages: 551-558
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Polymer coating of ferrite nanoparticles by using "connecter" chemical compounds. (2005)
  • Author(s): Tsubouchi, S., Nishio, K., Ikeda, M., Narimatsu, H., Gokon, N., Handa, H.Abe, M.
  • Journal Title: Proceedings of the Ninth International Conference on Ferrites (ICF-9) Pages: 499-454
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Selective ligand purification using high-performance affinity beads. (2005)
  • Author(s): Ohtsu, Y., Ohba, R., Imamura, Y., Kobayashi, M., Hatori, H., Zenkoh, T., Hatakeyama, M., Manabe, T., Hino, M., Yamaguchi, Y, Kataoka, K., Kawaguchi, H., Watanabe, H., Handa, H.
  • Journal Title: Anal.Biochem. 338 Pages: 245-252
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria. (2005)
  • Author(s): Kamada N, Hisamatsu T, Okamoto S, Sato T, Matsuoka K, Arai K, Nakai T, Hasegawa A, Inoue N, Watanabe N, Akagawa KS, Hibi T
  • Journal Title: J.Immunol 175 Pages: 6900-6908
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response. (2005)
  • Author(s): Sato T, Nakai T, Tamura N, Okamoto S, Matsuoka K, Sakuraba A, Fukushima T, Uede T, Hibi T
  • Journal Title: Gut 54 Pages: 1254-1262
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Novel preparation method of magnetic nanobeads for medical use. (2005)
  • Author(s): Abe, M., Handa, H.
  • Journal Title: Oyo Buturi 74,12 Pages: 1580-1583
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] ULTRA HIGH SENSITIVITY INSB MICRO-HALL BIOSENSOR SYSTEM FOR HIGH SPEED BIOSCREENING APPLICATIONS (2004)
  • Author(s): H.Sanbonsugi, M.Abe, A.Sandhu, H.Handa
  • Journal Title: Proceedings of The Ninth International Conference on Ferrites (ICF-9) Pages: 419-424
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 特集バイオ・医療を志向する次世代の磁性微粒子<基礎編>医用磁性ナノビーズの新規作製技術 (2004)
  • Author(s): 阿部正紀, 半田宏
  • Journal Title: バイオインダストリー 8 Pages: 7-13
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 医用磁性ナノビーズのポストゲノム解析時代における新展開 (2004)
  • Author(s): 阿部正紀, 半田宏
  • Journal Title: 日本応用磁気学会誌 28,7 Pages: 841-846
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] High Sensitivity InSb Ultra-Thin+Film Micro-Hall Sensors for Bioscreening Applications (2004)
  • Author(s): Adarsh Sandhu, Hideaki Sanbonsugi, Ichiro Shibasaki, Masanori Abe, Hiroshi Handa
  • Journal Title: Japanese J. Applied Physics No.7 A Pages: 868-870
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthesis of affinity nanoparticles coupled to FR901464 derivatives. (2004)
  • Author(s): Imamura, Y., Ohtsu, Y., Tanaka, H., Hatakeyama, M., Manabe, T., Kawaguchi, H., Handa, H., Takahashi, T.
  • Journal Title: Heterocycles 64 Pages: 51-56
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthesis of monodisperse ferrite nanoparticles coated with polyacrylic acid (PAA). (2004)
  • Author(s): Nishio, K., Hasegawa, M., Ikeda, M., Narimatsu, H., Hase, Y., Ogura, Y., Gokon, N., Tsubouchi, S., Hatakeyama, M., Abe, M., Handa, H.
  • Journal Title: Trans. Mater. Res. Soc. Jpn. 29 Pages: 1659-1662
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammtory bowel disease. (2004)
  • Author(s): Sato T, Kanai T, Watanabe M, Sakuraba A, Okamoto S, Nakai T, Okazawa A, Inoue N, Totsuka T, Yamazaki M, Kroczek RA, Fukushima T, Ishii H, Hibi T
  • Journal Title: Gastroenterology 126 Pages: 829-839
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Limited capability of regional lymph nodes to eradicate metastatic cancer cells. (2004)
  • Author(s): Nagata H, Arai T, Soejima Y, Suzuki H, Ishii H, Hibi T
  • Journal Title: Cancer Res 64(22) Pages: 8239-8248
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] T-bet up-regulation and subsequent interleukin 12 stimulation are essential for the induction of Th1 mediated immunopathology in Crohn's disease. (2004)
  • Author(s): Matsuoka K, Inoue N, Sato T, Okamoto S, Hisamatsu T, Kishi Y, Sakuraba A, Hitotsumatsu O, Fukushima T, Kanai T, Watanabe M, Ishii H, Hibi T
  • Journal Title: Gut 53 Pages: 1303-1308
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A specific genetic alteration on chromosome 6 in ulcerative colitis-associated colorectal canders. (2004)
  • Author(s): Ezaki T, Watanabe M, Kanai T, Ogata H, Iwao Y, Ishii H, Hibi T
  • Journal Title: Cancer Res 63 Pages: 3747-3749
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] High Sensitivity InSb Ultra-Thin Film Micro-Hall Sensors for Bioscreening Applications (2004)
  • Author(s): Adarsh Sandhu, Hideaki Sanbonsugi, Ichiro Shibasaki, Masanori Abe, Hiroshi Handa
  • Journal Title: Japanese J.Applied Physics No.7A Pages: 868-870
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthesis of monodisperse ferrite nanoparticles coated with polyacrylic acid (PAA). (2004)
  • Author(s): Nishio, K., Hasegawa, M., Ikeda, M., Narimatsu, H., Hase, Y., Ogura., Y, Gokon, N., Tsubouchi, S., Hatakeyama, M., Abe, M., Handa, H.
  • Journal Title: Trans.Mater.Res.Soc.Jpn. 29 Pages: 1659-1662
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease. (2004)
  • Author(s): Sato T, Kanai T, Watanabe M, Sakuraba A, Okamoto S, Nakai T, Okazawa A, Inoue N, Totsuka T, Yamazaki M, Kroczek RA, Fukushima T, Ishii H, Hibi T
  • Journal Title: Gastroenterology 126 Pages: 829-839
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Limited capability of regional lymph nodes to eradicate metastatic cancer cells. (2004)
  • Author(s): Nagata H, Arai T, Soejima Y, Suzuki H, Ishii H, Hibi T
  • Journal Title: Cancer Res. 64(22) Pages: 8239-8248
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] T-bet up-regulation and subsequent interleukin 12 stimulation are essential for the induction of Th1 mediated immunopathology in Crohn's disease (2004)
  • Author(s): Matsuoka K, Inoue N, Sato T, Okamoto S, Hisamatsu T, Kishi Y, Sakuraba A, Hitotsumatsu O, Fukushima T, Kanai T, Watanabe M, Ishii H, Hibi T
  • Journal Title: Gut 53 Pages: 1303-1308
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A specific genetic alteration on chromosome 6 in ulcerative colitis-associated colorectal cancers. (2004)
  • Author(s): Ezaki T, Watanabe M, Kanai T, Ogata H, Iwao Y, Ishii H, Hibi T
  • Journal Title: Cancer Res. 63 Pages: 3747-3749
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Novel Techniques for Fabricating Magnetic Nanobeads (2004)
  • Author(s): Abe, M., Handa, H.
  • Journal Title: Bio Industry 8 Pages: 7-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prospects for Medical Applications Using Magnetic Beads in the Post-Genomic Era (2004)
  • Author(s): Abe, M., Handa, H.
  • Journal Title: J.Mag.Soc.Jpn 28,7 Pages: 841-846
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Direct immobilization of fluorescent dyes onto ferrite nanoparticles during their synthesis from aqueous solution (2003)
  • Author(s): S.Hatanaka, N.Matsushita, M.Abe, K.Nishimura, M.Hasegawa, H.Handa
  • Journal Title: J. Appl. Phys 93, 10 Pages: 7569-7570
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Method for synthesizing ferrite nanoparticles 〜30 nm in diameter on neutral pH condition for biomedical applications (2003)
  • Author(s): M.Tada, S.Hatanaka, H.Sanbonsugi, N.Matsushita, M.Abe
  • Journal Title: J. Appl. Phys 93, 10 Pages: 7566-7568
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Direct immobilization of fluorescent dyes onto ferrite nanoparticles during their synthesis from aqueous solution (2003)
  • Author(s): S.Hatanaka, N.Matsushita, M.Abe, K.Nishimura, M.Hasegawa, H.Handa
  • Journal Title: J.Appl.Phys 93,10 Pages: 7569-7570
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Method for synthesizing ferrite nanoparticles 〜30 nm in diameter on neutral pH condition for biomedical applications (2003)
  • Author(s): M.Tada, S.Hatanaka, H.Sanbonsugi, N.Matsushita, M.Abe
  • Journal Title: J.Appl.Phys 93,10 Pages: 7566-7568
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Novel Ferrite Films and Fine Particles Prepared at 3〜 100℃ by a Soft Solution Processing and Their Applications (2003)
  • Author(s): Masanori Abe
  • Journal Title: CIMTEC 2002- 10th International Ceramics Congress and 3rd Forum on New Materials, (Florence, Italy, July, 14-19, 2002) Pages: 501-510
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of affinity-purification technology for identification of drug receptors. (2003)
  • Author(s): Hasegawa, M., Uga, H., Ohba, R., Tsuboi, Y., Sato, I., Tang, J., Kabe, Y., Handa, H.
  • Journal Title: Recent Res.Develp.Biophys.Biochem. 3 Pages: 445-456
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Microwave and Nano-biomagnetic Applications of Ferrite Thin Films and Fine Particles Prepared from an Aqueous Solution (2003)
  • Author(s): Abe, M., Handa, H.
  • Journal Title: J.Mag.Soc.Jpn 27,6 Pages: 721-729
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Novel Ferrite Films and Fine Particles Prepared at 3〜100℃ by a Soft Solution Processing and Their Applications (2002)
  • Author(s): Masanori Abe
  • Journal Title: CIMTEC 2003 - 10th International Ceramics Congress and 3rd Forum on New Materials, (Florence, Italy, July 14-19, 2002) Pages: 501-510
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Detection of magnetically labeled DNA using pseudomorphic ALGaAs/InGaAs/GaAs heterostructure micro-Hall biosensor.
  • Author(s): Togawa, K., Sanbonsugi, H., Sandhu, A., Narimatsu, H., Nishio, K., Handa, H.
  • Journal Title: J. Appl. Phys. (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Detection of magnetically labeled DNA using pseudomorphic AlGaAs/InGaAs/GaAs heterostructure micro-Hall biosensor
  • Author(s): Togawa, K., Sanbonsugi, H., Sandhu, A., Narimatsu, H., Nishio, K., Handa, H.
  • Journal Title: J.Appl.Phys. (In press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 遺伝子医学M00K5号 ナノ磁性微粒子による遺伝子導入法 (2006)
  • Author(s): 野村祥太郎, 望月勇輔, 西尾広介, 阪本聡, 半田宏(分担)
  • Total Pages: 6
  • Publisher: 株式会社メディカル ドゥ
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 4,2 MRイメージング用ナノ磁性ビーズ、医療機器と再生医療 -開発最前線と今後の同港- (2005)
  • Author(s): 阿部正紀, 半田宏(分担)
  • Total Pages: 11
  • Publisher: 情報機構
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 14,医用・磁性ナノビーズ ナノ粒子の製造・評価・応用・機器の最新技術 (2002)
  • Author(s): 阿部正紀, 半田宏(分担)
  • Total Pages: 4
  • Publisher: シーエムシー出版
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 磁性ビーズのバイオ・環境技術への応用展開
  • Author(s): 半田宏, 阿部正紀, 野田紘喜(監修)
  • Publisher: シーエムシー出版
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 磁気ビーズセパレータ (2005)
  • Inventor(s): 阿部正紀, 多田大, 嶋津隆一
  • Industrial Property Rights Holder: 東京工業大学
  • Industrial Property Number: 特許、2005-106564(出願番号)
  • Filing Date: 2005-04-01
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] ポリマー被覆微粒子の製造方法およびポリマー被覆微粒子 (2004)
  • Inventor(s): 半田宏, 阿部正紀, 郷右近展之, 壷内信吾, 畠山士, 西尾広介, 池田森人, 成松宏樹
  • Industrial Property Rights Holder: 財団法人理工学振興会
  • Industrial Property Number: 特許、2004-363638
  • Filing Date: 2004-12-15
  • Description: 「研究成果報告書概要(和文)」より