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2005 Fiscal Year Final Research Report Summary

Translational research in the establishment of treatment strategy for gastrointestinal cancers

Research Project

Project/Area Number 15209040
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionOsaka University

Principal Investigator

MONDEN Morito  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (00127309)

Co-Investigator(Kenkyū-buntansha) SEKIMOTO Mitsugu  Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (10273658)
FUJIWARA Yoshiyuki  Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (40314330)
YAMAMOTO Hirofumi  Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (30322184)
IKEDA Masataka  Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (80335356)
Project Period (FY) 2003 – 2005
KeywordsDigestive organ cancer / DNA chip / gene expression profile / Translational research
Research Abstract

The aim of this project is to establish the prediction system for the metastasis/prognosis or behavior of gastrointestinal cancers, using molecular biology such as the DNA chip technology, which would have been limited with the conventional clinicopathological diagnosis. This project contains the two major branches, one is multicenter registration system of thousands of cancer samples and their clinicopathological information as the clinical field, and the other is comprehensive molecular analyses system of them using whole human gene 30K DNA chip as the basic research field.
Our results are follows.
1.Approximately 4000 gastrointestinal cancer samples and their detailed pathological information and their prognosis including overall and disease free survival have been collected by the cooperation of 11 hospitals of our series participated in this project.
2.Whole human gene expressions of several hundred samples of each cancer were obtained with 30K DNA chip.
3.The data mining of both huge clinicopathological and molecular information was done with sophisticated statistics.
4.The candidate genes that may be related to or may play an important role for each carcinogenesis such as colorectal, gastric, hepatocellular, esophageal, and pancreatic cancer were identified.
5.After the recognition of the characteristic gene expression patterns correlated with metastasis, recurrence, prognosis, and responsibility for chemotherapy and/or radiotherapy of each cancer, we are succeeded in the establishment of prediction system for the tumor behavior using the results of such gene expression profiles.

  • Research Products

    (24 results)

All 2005 2004 2003

All Journal Article (23 results) Book (1 results)

  • [Journal Article] Prediction of recurrence in advanced gastric cancer patients after curative resection by gene expression profiling.2005

    • Author(s)
      Motoori M., et al.
    • Journal Title

      Int J Cancer 114(6)

      Pages: 963-968

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] DNA chipの癌臨床への応用-大腸癌診断用DNA chip (Mini Chip)の開発・作製-『消火器病学の進歩2005-モノグラフ 消火器病学のニューフロンティア編』2005

    • Author(s)
      山崎誠, 他
    • Journal Title

      財団法人日本消火器病学会

      Pages: 404-407

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Prediction of recurrence in advanced gastric cancer patients after curative resection by gene expression profiling.2005

    • Author(s)
      Motoori M., et al.
    • Journal Title

      Int J Cancer. 114(6)

      Pages: 963-968

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Molresular Prediction of Response to 5-Fluorouracil and Interferon-f Combination Chemotherapy on Advanced Hepatocellular Carcinoma.2004

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      Clinical Cancer Research 10

      Pages: 6029-6038

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Molecular-based prediction of early recurrence in hepatosellular carsinoma.2004

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      Journal of Hepatology 41

      Pages: 284-291

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] PCR-array Gene Expression Profiling of Hepatocellular Carcinoma.2004

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      J.Exp.Clin.Cancer Res 23(1)

      Pages: 135-141

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Identification of Differentially Expressed Genes Involved in Colorectal Carcinogenesis Using a cDNA Microarray.2004

    • Author(s)
      Komori T., et al.
    • Journal Title

      J.Exp.Clin.Cancer Res 23(3)

      Pages: 521-527

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] バイオインフォマティクスに基づく大腸癌の臨床-DNAチップの解析手法と臨床応用-2004

    • Author(s)
      竹政伊知朗, 他
    • Journal Title

      医学のあゆみ 208(8)

      Pages: 694-695

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] PCRアレイを用いた肝細胞癌の網羅的遺伝子発現解析-新しいバイオマーカーの探索-2004

    • Author(s)
      黒川幸典, 他
    • Journal Title

      癌の臨床 50(1)

      Pages: 21-26

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 分子診断学の進歩と癌検診への応用-DNAチップ技術による大腸癌の遺伝子発現プロファイル解析と臨床応用2004

    • Author(s)
      竹政伊知朗, 他
    • Journal Title

      日本がん検診・診断学会 11(2)

      Pages: 21-25

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] DNAチップによる癌の個別化診断・治療時代の到来2004

    • Author(s)
      竹政伊知朗, 他
    • Journal Title

      外科治療 91(4)

      Pages: 485-491

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Molecular Prediction of Response to 5-Fluorouracil and Interferon-α Combination Chemotherapy on Advanced Hepatocellular Carcinoma.2004

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      Clinical Cancer Research 10

      Pages: 6029-6038

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Molecular-based prediction of early recurrence in hepatocellular carcinoma.2004

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      Jounal of Hepatology 41

      Pages: 284-291

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Identification of Differentially Expressed Genes Involved in Colorectal Carcinogenesis Using a cDNA Microarray.2004

    • Author(s)
      Komori T., et al.
    • Journal Title

      J.Exp.Clin.Cancer Res. 23(3)

      Pages: 521-527

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Analytical technique and clinical application - of clinical - DNA chip of large bowel cancer based on bioinformatics.2004

    • Author(s)
      Takemasa I., et al.
    • Journal Title

      Medical Ayumi 208(8)

      Pages: 694-695

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Search - of the biomarker that cyclopedic gene expression analysis - is new of the hepatocellular carcinoma which I used PCR array for.2004

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      Rinsyou of cancer 50(1)

      Pages: 21-26

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Gene expression profile analysis and clinical application of large bowel cancer by applied - DNA chip technology to progress and a cancer checkup of molecule diagnostics.2004

    • Author(s)
      Takemasa I., et al.
    • Journal Title

      Japanese cancer screening/diagnostics society 11(2)

      Pages: 21-25

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The arrival of an individualization diagnosis / the treatment times of cancer with DNA chip.2004

    • Author(s)
      Takemasa I., et al.
    • Journal Title

      Surgery treatment 91(4)

      Pages: 485-491

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Molecular features of non-B, non-C hepatocellular carcinoma: a PCR-array gene expression profiling study.2003

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      J Hepatol 39(6)

      Pages: 1004-1012

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Identification of expressed genes linked to malignancy of human colorectal carcinoma by parametric clustering of quantitative expression data.2003

    • Author(s)
      Muro S., et al.
    • Journal Title

      Genome Biol 4(3)

      Pages: R21

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A bayesian missing value estimation method for gene expression profile data.2003

    • Author(s)
      Oba S., et al.
    • Journal Title

      Bioinformatics 19(16)

      Pages: 2088-2096

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Molecular features of non-B,non-C hepatocellular carcinoma : a PCR-array gene expression profiling study.2003

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      J Hepatol 39(6)

      Pages: 1004-1012

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A bayesian missing value estimation method for gene expression profile data.2003

    • Author(s)
      Oba S., Sato M., Takemasa I., Monden M., Matsubara K., Ishii S.
    • Journal Title

      Bioinformatics 19(16)

      Pages: 2088-2096

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] DNA chip for cancer clinical への application-large bowel cancer diagnoses of DNA chip(Mini Chip) development/manufacture-.2005

    • Author(s)
      Yamasaki M., et al.
    • Total Pages
      404-407
    • Publisher
      Japan digestive organ disease society Foundation
    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2007-12-13  

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