2005 Fiscal Year Final Research Report Summary
Application of Bioabsorbable Block Copolymers Containing Poly(Ethylene Glycol) as Medical Materials
| Project/Area Number |
15300172
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | Kansai University |
|---|
Principal Investigator |
OHYA Yuichi Kansai University, Faculty of Engineering, Associate Professor, 工学部, 助教授 (10213886)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OUCHI Tatsuro Kansai University, Faculty of Engineering, Professor, 工学部, 教授 (60067650)
日本油脂株式会社, 筑波研究所, 研究員
TANAKA Shinji NOF Corporation, Researcher
|
|---|
| Project Period (FY) |
2003 – 2005
|
| Keywords | Poly(lactic acid) / Polydepsipeptide / Poly(ethylene glycol) / Anti-adhesive membrane / Biodegradable materials / Biocompatibility / Bioabsrobability / Block copolymers |
|---|
| Research Abstract |
In order to develop material for bioabsorbable anti-adhesive membrane, amphiphilic ABA-type triblock copolymers were synthesized. A segment is poly[L-lactide(LA)-r-depsipeptide] (poly[LA-r-(Glc-Leu)] : PLGL or poly[LA-r-(Glc-Phe)] : PLGF) and B segment is poly(ethylene glycol) (PEG) (Mn=10,000 and Mn=20,500). The synthesis of the triblock copolymer (PLGL-PEG-PLGL and PLGF-PEG-PLGF) was carried out via ring-opening copolymerization of L-lactide and cyclo(Glc-Leu) or cyclo(Glc-Phe) in the presence of hydroxytelechelic poly(ethylene glycol) using tin 2-ethylhexanoate as a catalyst. In this study, to evaluate the copolymers as a candidate for bioabsorbable anti-adhesive membrane, physicochemical properties such as degradation behavior under physiological condition and water absorption behavior of PLGL-PEG-PLGL and PLGF-PEG-PLGF films were investigated and compared with polylactide-PEG-polylactide (PLLA-PEG-PLLA) triblock copolymer. The PLGF-PEG-PLGF films showed higher Young's modulus and longer elongation to break than PLGL-PEG-PLGL films and PLLA-PEG-PLLA. The degradation rate of PLGL-PEG-PLGL and PLGF-PEG-PLGF films could be varied by controlling the molecular architectures, such as molecular weight of hydrophilic B segment and depsipeptide unit content in A segment. The degradation rate of PLGF-PEG-PLGF films was slightly higher than that of PLGL-PEG-PLGL films having similar molecular weight and content of depsipeptide unit. The biocompatibility and absorption behavior of the PLGL-PEG-PLGL films were also evaluated in vivo. The films were implanted subcutaneously into ddy-mice. The results showed that the PLGL-PEG-PLGL films were absorbed gradually in vivo without inflammation.
|
Research Products
(21 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] Biomaterial Science2003
Author(s)
K.Ishihara, K.Hatanaka, T.Yamaoka, Y.Ohya
Total Pages
206
Publisher
Tokyo Kagaku Dojin Co.Ltd.
Description
「研究成果報告書概要(欧文)」より
-
