2004 Fiscal Year Final Research Report Summary
Analysis of spatio-temporarl mechanisms on outer plexiform layer in retina by the multichannel microprobe electrodes array chip
| Project/Area Number |
15360218
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Measurement engineering
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| Research Institution | RIKEN |
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Principal Investigator |
USUI Shiro RIKEN, LABORATORY FOR NEUROINFORMATICS, LABORATORY HEAD, ニューロンインフォマティクス技術開発チーム, チームリーダー (40023337)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Makoto TOYOHASHI UNIVERSITY OF TECHNOLOGY, PROFESSOR, 工学部, 教授 (30126924)
ISHEHARA Akito CHUKYO UNIVERSITY, ASSISTANT PROFESSOR, 生命システム工学部, 講師 (80387620)
YAMAJI Kazutsuna RIKEN, LABORATORY FOR NEUROINFORMATICS, RESEARCH SCIENTIST, ニューロンインフォマティクス技術開発チーム, 研究員 (50373379)
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| Project Period (FY) |
2003 – 2004
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| Keywords | retina / multichannel recording / mathematical models / electroretinogram(ERG) / bipolce cell / horizontal cell / microprobe electrode |
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| Research Abstract |
We have developed multichannel microprobe electrode array chips for recording neural responses to light from retina, and mathematical model of retinal neurons to analyze retinal mechanisms involved in the recorded light-induced responses.
Prototypes of the microprobe electrode array(MEA) chip have been fabricated on Si(111) substrates by selective Vapor-Liquid-Solid(VLS) growth method. The prototype MEA could detect light responses whose characteristics to a white flash and sensitivities to monochromatic stimulus were consistent with photopic electoretinogram(ERG). We also demonstrated that the changes of localized ERG responses were obtained with stimulus of slit light by the MEA.
In order to analyze inner retinal mechanisms involved in the measured ERG responses, we have developed models of retinal neuron and the retinal neural circuit by physiological engineering technique. The models of horizontal cell and bipolar cells which is closely related to form b-wave in ERG responses were described mathematically by their ionic mechanisms. It is allow us to analyze the relationship between light responses and the ionic mechanisms in their neuron.
These results suggest that the developed MEA chip is applicable to retinal neural recordings as a new measurement tool, and the models of retinal neuron would play a role to understand visual information preprocessing of retina.
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Research Products
(14 results)
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[Journal Article] Selective Vapor-liquid-solid Epitaxial Growth of Micro-Si Probe Electrode Arrays With On-chip MOSFETs on Si (111) Substrates2004
Author(s)
Kawano, T., Kato, Y., Tani, R., Takao, H., Sawada, K., Ishida M.
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Journal Title
IEEE Trans.Electron Device 51
Pages: 415-420
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Three-Dimensional Multichannel Si Microprobe Electrode Array Chip for Analysis of the Nervous System2004
Author(s)
Kawano, T., Ishihara, A., Harimoto, T., Takao, H., Sawada, K., Usui, S., Ishida, M.
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Journal Title
Proceeding of the IEEE International Electron Devices Meeting
Pages: 1013-1016
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Selective vapor-liquid-solid epitaxial growth of micro-Si probe electrode arrays with on-chip MOSFETs on Si(111) substrates2004
Author(s)
Kawano, T., Kato, Y., Tani, R., Takao, H., Sawada, K., Ishida, M.
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Journal Title
IEEE Trans.Electron Device Vol.51
Pages: 415-420
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Signal conditioning CMOS circuits integrated on Si(111) for image-recording sensor of neural activity2003
Author(s)
Kato, Y., Kawano, T., Ito, Y., Takao, H., Sawada, K., Ishida, M.
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Journal Title
IEEJ Trans.Sensors and Micromachines Vol.123
Pages: 363-367
Description
「研究成果報告書概要(欧文)」より
