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2005 Fiscal Year Final Research Report Summary

Atypical symptoms caused by bovine viral diarrhea virus infection

Research Project

Project/Area Number 15380212
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical veterinary science
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

TAJIMA Motoshi  Hokkaido Univ., Grad.School of Vet.Med., Assoc.Prof., 大学院・獣医学研究科, 助教授 (90202168)

Co-Investigator(Kenkyū-buntansha) OCHIAI Kenji  Hokkaido Univ., Grad.School of Vet.Med., Assoc.Prof., 大学院・獣医学研究科, 助教授 (80214162)
SAKODA Yoshihiro  Hokkaido Univ., Grad.School of Vet.Med., Assoc.Prof., 大学院・獣医学研究科, 助教授 (40333637)
Project Period (FY) 2003 – 2005
KeywordsBovine viral diarrhea virus / BVDV / virus distribution / pathogenisity / disorder of CNS / virus gene
Research Abstract

We examined the relationship between clinical symptoms in persistently infected cattle (PI) with bovine viral diarrhea virus (BVDV) and subgenotypes of the virus isolated from the PI. Subgenotypes were identified based on diversity of nucleotide sequence of BVDV E2 coding region. By the phylogenetic analysis, 13 iolates were classified in 1c subgenotype. Some PI infected with BVDV 1c indicated disorder of central nervous system (CNS) characterized by locomotive abnormalities, and had pathological changes in cerebrum on necropsy. All BVDV infected from PI complicated diabetes mellitus (DM) were classified in 1a subgenotype. These BVDV 1a were genetically close correlation each other and made a small cluster in phylogenetic tree.
The results mentioned above suggested that disorder of CNS and DM in BVDV PI had relevance to the subgenotypes of BVDV. Then the cerebrum of PI infected with BVDV 1c was examined histologicaly. Although specific distribution of virus in cerebrum was not recognized, BVDV 1c tended to invade cerebrum neurocytes compared to other subgenotypes of BVDV. By the quantitative PCR, virus titers were almost the same in individual other organs such as lymphnode, lever, spleen and so on.
Poor growth has been recognized frequently in BVDV PI all over the world. The genotypes of BVDV isolated from these PI were estimated. There was not relevance between subgenotype and poor growth. However, in PI complicated with poor growth, hypoplastic of thyroid gland were often recognized. Based on these facts and our previous investigations, poor growth complicated with BVDV infection seemed to be caused by autoimmune disorder induced by BVDV, not to be direct influence of BVDV infection.

  • Research Products

    (10 results)

All 2005 2004

All Journal Article (10 results)

  • [Journal Article] Genetic and clinical analyses of bovine viral diarrhea virus isolated in the United States of America2005

    • Author(s)
      Tajima, M., Dubovi, E.J.
    • Journal Title

      Journal of Veterinary Diagnostic Investigation 17・1

      Pages: 8-13

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Relationship of bovine viral diarrhea virus persistent infection to incidence of diseases on dairy farms based on bulk tank milk test by RT-PCR2005

    • Author(s)
      Kozasa, T. et al.
    • Journal Title

      Veterinary Microbiology 106・1

      Pages: 41-47

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Genetic and clinical analyses of bovine viral diarrhea virus isolated in the United States of America.2005

    • Author(s)
      Tajima, M., Dubovi, E.J.
    • Journal Title

      Journal of Veterinary Diagnostic Investigation 17-1

      Pages: 8-13

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Relationship of bovine viral diarrhea virus persistent infection to incidence of diseases on dairy farms based on bulk tank milk test by RT-PCR.2005

    • Author(s)
      Kozasa, T., Tajima, M., Yasutomi, Y., Sano, K., Ohashi, K., Onuma, M.
    • Journal Title

      Veterinary Microbiology 106-1

      Pages: 41-47

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Bovine viral diarrhea virus 1 is classified into different subgenotypes depending on the analyzed region within the viral genome2004

    • Author(s)
      Tajima, M
    • Journal Title

      Veterinary Microbiology 99・1

      Pages: 131-138

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 臨床症状を指標とした牛ウイルス性下痢ウイルスの汚染状況調査2004

    • Author(s)
      小佐々隆志ら
    • Journal Title

      日本獣医師会雑誌 57・8

      Pages: 511-514

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] バルク乳中抗体の検出による牛ウイルス性下痢ウイルスの浸潤状況調査2004

    • Author(s)
      小佐々隆志ら
    • Journal Title

      日本獣医師会雑誌 57・11

      Pages: 705-709

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Bovine viral diarrhea virus 1 is classified into different subgeno-types depending on the analyzed region within the viral genome2004

    • Author(s)
      Tajima M.
    • Journal Title

      Veterinary Microbiology 99-1

      Pages: 131-138

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Surveillance of bovine viral-diarrhea virus infection in diseased cattle.2004

    • Author(s)
      Kozasa, T., Tajima, M., Ohashi, K., Onuma, M.
    • Journal Title

      Japanese Journal of Veterinary Medical Association 57-8

      Pages: 511-514

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Detecting the neutralizing antibody in bulk-milk whey to investigate prevalence of infection with the bovine viral-diarrhea virus.2004

    • Author(s)
      Kozasa, T., Tajima, M., Sano, K., Yasutomi, I., Ohashi, K., Onuma, M.
    • Journal Title

      Japanese Journal of Veterinary Medical Association 57-11

      Pages: 705-709

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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