2005 Fiscal Year Final Research Report Summary
Pharmacological investigation for mechanisms of cerebral hemorrhage induced by anti-thrombotic agents
| Project/Area Number |
15390173
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
UMEMURA Kazuo Hamamatsu University School of Medicine, Professor, 医学部, 教授 (40232912)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Yasuhiro Hamamatsu University School or Medicine, Assistant Professor, 医学部, 助手 (00324343)
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| Project Period (FY) |
2003 – 2005
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| Keywords | stroke / cerebral hemorrhage / heparin / tPA / MMP-9 |
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| Research Abstract |
Cerebral hemorrhage associated with antithrombotic and thrombolytic therapy in acute stroke is a major clinical problem. We investigated the roles of endogenous tPA and MMPs in hemorrhagic cerebral infarction associated with heparin. We demonstrated that heparin administration caused cerebral hemorrhage in WT but not in KO. Heparin administration increased tPA activity and its mRNA expression in WT. We also observed an induction of MMP9 and its mRNA expression by heparin administration in WT but not in KO. Our findings suggest that endogenous tPA plays an important role in heparin-produced cerebral hemorrhage via MMP9 induction and activation.
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