2006 Fiscal Year Final Research Report Summary
Regenerative Medicine of Nephron Segments
| Project/Area Number |
15390265
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
TERADA Yoshio Tokyo Medical and Dental University, Associate Professor, 医学部附属病院, 助教授 (30251531)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
INOSHITA Seiji Tokyo Medical and Dental University, Assistant Professor, 医学部附属病院, 助手 (00345307)
|
|---|
| Project Period (FY) |
2003 – 2006
|
| Keywords | Kidney / Regeneration / Renal tubule / Acute renal failure / Stem cell / Differentiation / Notch / Delta |
|---|
| Research Abstract |
Ischemic acute renal failure (ARF) is the most common form of ARF in the adult population. The molecular mechanisms of tubular regeneration after ischemic renal injury remain largely unknown. It has been suggested that regeneration processes may recapitulate developmental processes in order to restore organ or tissue function. The adult tubular epithelial cells have a potent ability of regenerate after cellular damage. We examined functional role of two developmental genes, Wnt-4 and Ets-1 in renal tubular regeneration in ARF. This slide shows hypothesis of mechanisms of renal tubular regeneration. After renal tubular injury, such as ischemia, renal tubular cells falls into apoptosis or necrosis. Then, some parts of injured renal tubules regenerate. We hypothesized three possibilities of renal tubular regeneration. One is the presence of renal tubular stem cells. Concerning to the stem cells, mamy presentation have already been reported in this meeting. The second possibility is Dedifferentiation. Our hypothesis is that the renal tubular cells transform to dedifferentiated cells, which have embryonic character, such as expression of Wnt-4 and Ets-1. The other possibility is involvement of blood cells.
In summary, we demonstrated that when the renal tubular cells are damaged, several recovery mechanisms are occurs using many types of stem cells. We may improve the recovery of renal tubular damage by manipulating stem cells such as tissue specific stem cells, or dedifferentiated stem cells, bone-marrow deribed stein cells, or ES cells. Further understanding of renal regeneration will improve new therapeutic strategy for ARF.
|
Research Products
(12 results)
-
-
-
-
-
-
-
-
[Journal Article] Human mesanchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissues.2005
Author(s)
T.Yokoo, T.Ohashi, JS.Shen, K.Sakurai, Y.Miyazaki, Y.Utsunomiya, M.Takahashi, Y.Terada, Y.Eto, T.Kawamura, T.Hosoya
-
Journal Title
Pro Nat Aca Sci USA Vol.102
Pages: 3296-3300
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Evidence for megalin-mediated proximal tubular uptake of L-FABP, a carrier of potentially nephrotoxic molecules.2005
Author(s)
Y.Oyama, T.Takeda, H.Hama, A.Tanuma, N.Iino, K.Sato, R.Kaseda, M.Ma, T.Yamamoto, H.Fujii, J.Kazama, S.Odani, Y.Terada, K.Mizut, F.Gejyo, A.Saito
-
Journal Title
Lab Invest Vol.85
Pages: 522-531
Description
「研究成果報告書概要(欧文)」より
-
-
-
