2005 Fiscal Year Final Research Report Summary
Development of Simulation System for Radiotherapy Effect utilizing Complexity
| Project/Area Number |
15390353
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
SHIRATO Hiroki Hokkaido University Hospital, Department of Radiology, Associate Professor, 病院, 助教授 (20187537)
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| Co-Investigator(Kenkyū-buntansha) |
OHUCHI Azuma Hokkaido University, Graduate School of Engineering, Department of Information and Electronics, Professor, 大学院・工学研究科, 教授 (50002308)
TADANO Shigeru Hokkaido University, Graduate School of Engineering, Division of Human Mechanical Systems and Design, Professor, 大学院・工学研究科, 教授 (50175444)
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| Project Period (FY) |
2003 – 2005
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| Keywords | radiotherapy / complexity / simulation / finite element model / Tumor shrinkage |
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| Research Abstract |
We have investigated from two aspects about the radiation effect on the tumor shrinkage in radiotherapy. First, we assumed that the tumor is complexity consisted of cells which are interacting each other and to simulate the change of shape of tumor by the radiotherapy using two-dimensional cellular automaton model. One of the co-investigator, Ouchi A, has tried to use an automaton model for the shrinkage of the tumor by immuno-response using the parameters derived from in vivo studies. The modeling of the immunotherapy suggested that we need more solid information about the parameters for the application of the automaton model to the radiation reaction. On the other hand, we assumed that the tumor is a deformable material decreases it size in relation to the radiation dose. We applied stress-strain relationship to the dose-response relationship based on the linear-quadratic model for cell deaths. This approach has succeeded reasonably well with the change of tumor volume after radiotherapy for uterine cervix tumors. Integration of the simulation model in the adaptive radiotherapy will be important step in the four-dimensional intensity-modulated radiotherapy. More solid information is to be implemented in accordance with the achievement in molecular imaging technology.
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Research Products
(33 results)
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[Journal Article] Speed and amplitude of lung tumor motion precisely detected in four-dimensional setup and in real-time tumor-tracking radiotherapy.2006
Author(s)
Shirato H, Suzuki K, Sharp GC, Fujita K, Onimaru R, Fujino M, Kato N, Osaka Y, Kinoshita R, Taguchi H, Onodera S, Miyasaka K.
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Journal Title
Int J Radiat Oncol Biol Phys. 64(4)
Pages: 1229-1236
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Insertion and fixation of fiducial markers for setup and tracking of lung tumors in radiotherapy.2005
Author(s)
Imura M, Yamazaki K, Shirato H, Onimaru R, Fujino M, Shimizu S, Harada T, Ogura S, Dosaka-Akita H, Miyasaka K, Nishimura M.
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Journal Title
Int J Radiat Oncol Biol Phys. 63(5)
Pages: 1442-1447
Description
「研究成果報告書概要(欧文)」より
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