2003 Fiscal Year Annual Research Report

粒子線を軸にした難治癌の診断と治療法の開発

Research Project

Project/Area Number	15390362
Research Institution	Kobe University
Principal Investigator	杉村和朗神戸大学, 大学院・医学系研究科, 教授 (00136384)
Co-Investigator(Kenkyū-buntansha)	楫靖神戸大学, 医学部附属病院, 講師 (10273947) 藤井正彦神戸大学, 医学部附属病院, 助教授 (00228959) 副島俊典神戸大学, 大学院・医学系研究科, 助教授 (20231384) 村上昌雄兵庫県立粒子線医療センター, 部長(研究職) 菱川良夫兵庫県立粒子線医療センター, 院長(研究職)
Keywords	粒子線治療 / 陽子線 / 炭素イオン線 / 前立腺癌 / 骨軟部肉腫 / 悪性黒色腫 / 磁気共鳴画像 / PET
Research Abstract	まず,陽子線・炭素イオン線の臨床応用の前段階として,in vitroよびin vivoにて生物学的データの収集を行った.in vitroでは細胞照射実験により,in vivoではマウス腸管照射およびマウス皮膚照射により,各ビームの拡大ブラッグピーク内の異なる深さでの生物学的効果比を求め,臨床応用時の生物学的等価線量算出根拠とした. その後,兵庫県立粒子線医療センターにおいて,陽子線治療の臨床治験を開始した.これは陽子線治療装置の安全性・有効性を検討するためのもので,頭頚部・肺・肝・前立腺癌の患者30例を対象とした.内訳は頭頚部癌4例(脊索腫術後再発,上顎洞,篩骨洞,顎下腺),肺野型肺癌5例,肝癌5例(塞栓術後再発を含む),前立腺癌16例(ホルモン療法後を含む)であった.照射線量および分割回数はこれまで他施設から報告されている方法を参考に設定した.肺・肝癌に対しては呼吸同期照射を実施した.治療終了後1ヶ月時に効果判定を行い,治療開始90日目までの急性反応(米国国立癌研究所共通毒性基準第3版にて判定)を評価した.一次効果は良好で,急性反応も軽微であった.装置の大きなトラブルも経験しなかった. また,陽子線が組織に照射されたときに生成されるpositron emitterに着目して,PET (positron emission tomography)が陽子線照射範囲の検証に有用かどうかを検討した.陽子線治療直後の患者のPET画像を撮像し,治療計画における線量分布と比較したところ,PET画像における高輝度領域と治療計画における照射領域はよく一致した.つまり,陽子線治療直後にPET画像を撮像すれば,治療計画通りに照射されているかどうかを容易に検証することができるということが示された.

Research Products

(30 results)

All Other

All Publications (30 results)

[Publications] Akagi T: "Ridge filter design for proton therapy at Hyogo Jon Beam Medical Center."Phys Med Biol. 48(22). N301-N312 (2003)
[Publications] Ishikawa T: "Solitary fibrous tumor in the pelvic space."Urol Res. 32(1). 49-50 (2004)
[Publications] Zhang Z: "Combination with CD/5-FC gene therapy enhances killing of human bladder-cancer cells by radiation."J Gene Med. 5(10). 860-867 (2003)
[Publications] Gotoh A: "The growth inhibitory effect of p21 adenovirus on androgen-dependent and -independent human prostate cancer cells."BJU Int.. 92(3). 314-318 (2003)
[Publications] Hara I: "Clinical outcome of conservative therapy for stage T1, grade 3 transitional cell carcinoma of the bladder."Int J Urol.. 10(1). 19-24 (2003)
[Publications] Okano Y: "Biological effects of glycolic acid on dermal matrix metabolism mediated by dermal fibroblasts and epidermal keratinocytes."Exp Dermatol. 12S2. 57-63 (2003)
[Publications] Usuki A: "The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells."Exp Dermatol.. 12S2. 43-50 (2003)
[Publications] Budiyanto A: "Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells."J Invest Dermatol.. 121(5). 1088-1094 (2003)
[Publications] Tamura S: "Genistein enhances the cisplatin-induced inhibition of cell growth and apoptosis in human malignant melanoma cells."Pigment Cell Res.. 16(5). 470-476 (2003)
[Publications] Oka M: "Protein kinase C alpha associates with phospholipase D1 and enhances basal phospholipase D activity in a protein phosphorylation-independent manner in human melanoma cells."J Invest Dermatol.. 121(1). 69-76 (2003)
[Publications] Shirakawa T: "Messenger RNA levels and enzyme activities of 5 alpha-reductase types 1 and 2 in human benign prostatic hyperplasia (BPH) tissue."Prostate.. 58(1). 33-40 (2004)
[Publications] Gotoh A: "The growth inhibitory effect of p21 adenovirus on androgen-dependent and -independent human prostate cancer cells."BJU Int.. 92(3). 314-318 (2003)
[Publications] Hinata N: "Radiation induces p53-dependent cell apoptosis in bladder cancer cells with wild-type-p53 but not in p53-mutated bladder cancer cells."Urol Res.. 31(6). 387-396 (2003)
[Publications] Ohno Y: "Dynamic perfusion MRI versus perfusion scintigraphy : prediction of postoperative lung function in patients with lung cancer."AJR Am J Roentgenol. 82(1). 73-78 (2004)
[Publications] Mastuoka S: "Comparison of magnetic resonance imaging and ultrasonography in the prenatal diagnosis of congenital thoracic abnormalities."Fetal Diagn Ther. 18(6). 447-453 (2003)
[Publications] Ohno Y: "Clinical oxygen-enhanced magnetic resonance imaging of the lung."Top Magn Reson Imaging. 14(3). 237-243 (2003)
[Publications] Ejima Y: "Combination of genistein with ionizing radiation on surviving fraction, apoptosis and cell-cycle alterations on Du-145 prostate cancer cells."Int J Radiat Oncol Biol Phys. 57(2 Suppl). S353 (2003)
[Publications] Yamada K: "Prospective trial of combined transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma."Int I Radiat Oncol Biol Phys. 57(1). 113-119 (2003)
[Publications] Yamada K: "Radiotherapy for medically inoperable non-small cell lung cancer at clinical stage I and II."Tumori. 89(1). 75-79 (2003)
[Publications] Yamada K: "Three-dimensional treatment planning using electrocardiographically gated multi-detector row CT."Int J Radiat Oncol Biol Phys. 56(1). 235-239 (2003)
[Publications] Nishimura H: "Radiographic pulmonary and pleural changes after carbon ion irradiation."Int J Radial Oncol Biol Phys. 55(4). 861-868 (2003)
[Publications] Ohno Y: "Time-resolved contrast-enhanced pulmonary MR angiography using sensitivity encoding (SENSE)."J Magn Reson Imaging. 17(3). 330-336 (2003)
[Publications] Nishimura Y: "Severe complications in advanced esophageal cancer treated with radiotherapy after intubation of esophageal stents : a questionnaire survey of the Japanese Society for Esophageal Diseases"Int J Radiat Oncol Biol Phys. 56(5). 1327-1332 (2003)
[Publications] Sasaki R: "SUV by FDG-PET predicts outcome of non-small cell lung cancer"Int J Radiat Oncol Biol Phys. 57(2 Sup). S166 (2003)
[Publications] Fujishiro T: "Effect of cyclic mechanical stretch and titanium particles on prostaglandin E2 production by human macrophages in vitro."J Biomed Mater Res. 68A(3). 531-536 (2004)
[Publications] Yamamoto T: "Immunohistochemical analysis of platelet-derived growth factor and its receptors in soft tissue malignant fibrous histiocytoma."Anticancer Res.. 23(5b). 4325-4328 (2003)
[Publications] Yamamoto T: "Expression of stem cell factor and lack of c-kit expression in malignant fibrous histiocytoma of soft tissues."Anticancer Res.. 23(5b). 4305-4308 (2003)
[Publications] Nakatani T: "Expression of stem cell factor and c-kit in human malignant fibrous histiocytoma cell line (TNMY1)."Anticancer Res.. 23(3B). 2329-2333 (2003)
[Publications] Yamamoto T: "Management of liposarcoma occurring in pregnant women."Anticancer Res.. 23(1B). 799-802 (2003)
[Publications] 杉村和朗: "臨床医のための腹部血管造影・IVR"新興医学出版社. (2003)

2003 Fiscal Year Annual Research Report

粒子線を軸にした難治癌の診断と治療法の開発

Principal Investigator

杉村 和朗 神戸大学, 大学院・医学系研究科, 教授 (00136384)

Research Products

[Publications] Akagi T: "Ridge filter design for proton therapy at Hyogo Jon Beam Medical Center."Phys Med Biol. 48(22). N301-N312 (2003)

[Publications] Ishikawa T: "Solitary fibrous tumor in the pelvic space."Urol Res. 32(1). 49-50 (2004)

[Publications] Zhang Z: "Combination with CD/5-FC gene therapy enhances killing of human bladder-cancer cells by radiation."J Gene Med. 5(10). 860-867 (2003)

[Publications] Gotoh A: "The growth inhibitory effect of p21 adenovirus on androgen-dependent and -independent human prostate cancer cells."BJU Int.. 92(3). 314-318 (2003)

[Publications] Hara I: "Clinical outcome of conservative therapy for stage T1, grade 3 transitional cell carcinoma of the bladder."Int J Urol.. 10(1). 19-24 (2003)

[Publications] Okano Y: "Biological effects of glycolic acid on dermal matrix metabolism mediated by dermal fibroblasts and epidermal keratinocytes."Exp Dermatol. 12S2. 57-63 (2003)

[Publications] Usuki A: "The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells."Exp Dermatol.. 12S2. 43-50 (2003)

[Publications] Budiyanto A: "Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells."J Invest Dermatol.. 121(5). 1088-1094 (2003)

[Publications] Tamura S: "Genistein enhances the cisplatin-induced inhibition of cell growth and apoptosis in human malignant melanoma cells."Pigment Cell Res.. 16(5). 470-476 (2003)

[Publications] Oka M: "Protein kinase C alpha associates with phospholipase D1 and enhances basal phospholipase D activity in a protein phosphorylation-independent manner in human melanoma cells."J Invest Dermatol.. 121(1). 69-76 (2003)

[Publications] Shirakawa T: "Messenger RNA levels and enzyme activities of 5 alpha-reductase types 1 and 2 in human benign prostatic hyperplasia (BPH) tissue."Prostate.. 58(1). 33-40 (2004)

[Publications] Gotoh A: "The growth inhibitory effect of p21 adenovirus on androgen-dependent and -independent human prostate cancer cells."BJU Int.. 92(3). 314-318 (2003)

[Publications] Hinata N: "Radiation induces p53-dependent cell apoptosis in bladder cancer cells with wild-type-p53 but not in p53-mutated bladder cancer cells."Urol Res.. 31(6). 387-396 (2003)

[Publications] Ohno Y: "Dynamic perfusion MRI versus perfusion scintigraphy : prediction of postoperative lung function in patients with lung cancer."AJR Am J Roentgenol. 82(1). 73-78 (2004)

[Publications] Mastuoka S: "Comparison of magnetic resonance imaging and ultrasonography in the prenatal diagnosis of congenital thoracic abnormalities."Fetal Diagn Ther. 18(6). 447-453 (2003)

[Publications] Ohno Y: "Clinical oxygen-enhanced magnetic resonance imaging of the lung."Top Magn Reson Imaging. 14(3). 237-243 (2003)

[Publications] Ejima Y: "Combination of genistein with ionizing radiation on surviving fraction, apoptosis and cell-cycle alterations on Du-145 prostate cancer cells."Int J Radiat Oncol Biol Phys. 57(2 Suppl). S353 (2003)

[Publications] Yamada K: "Prospective trial of combined transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma."Int I Radiat Oncol Biol Phys. 57(1). 113-119 (2003)

[Publications] Yamada K: "Radiotherapy for medically inoperable non-small cell lung cancer at clinical stage I and II."Tumori. 89(1). 75-79 (2003)

[Publications] Yamada K: "Three-dimensional treatment planning using electrocardiographically gated multi-detector row CT."Int J Radiat Oncol Biol Phys. 56(1). 235-239 (2003)

[Publications] Nishimura H: "Radiographic pulmonary and pleural changes after carbon ion irradiation."Int J Radial Oncol Biol Phys. 55(4). 861-868 (2003)

[Publications] Ohno Y: "Time-resolved contrast-enhanced pulmonary MR angiography using sensitivity encoding (SENSE)."J Magn Reson Imaging. 17(3). 330-336 (2003)

[Publications] Nishimura Y: "Severe complications in advanced esophageal cancer treated with radiotherapy after intubation of esophageal stents : a questionnaire survey of the Japanese Society for Esophageal Diseases"Int J Radiat Oncol Biol Phys. 56(5). 1327-1332 (2003)

[Publications] Sasaki R: "SUV by FDG-PET predicts outcome of non-small cell lung cancer"Int J Radiat Oncol Biol Phys. 57(2 Sup). S166 (2003)

[Publications] Fujishiro T: "Effect of cyclic mechanical stretch and titanium particles on prostaglandin E2 production by human macrophages in vitro."J Biomed Mater Res. 68A(3). 531-536 (2004)

[Publications] Yamamoto T: "Immunohistochemical analysis of platelet-derived growth factor and its receptors in soft tissue malignant fibrous histiocytoma."Anticancer Res.. 23(5b). 4325-4328 (2003)

[Publications] Yamamoto T: "Expression of stem cell factor and lack of c-kit expression in malignant fibrous histiocytoma of soft tissues."Anticancer Res.. 23(5b). 4305-4308 (2003)

[Publications] Nakatani T: "Expression of stem cell factor and c-kit in human malignant fibrous histiocytoma cell line (TNMY1)."Anticancer Res.. 23(3B). 2329-2333 (2003)

[Publications] Yamamoto T: "Management of liposarcoma occurring in pregnant women."Anticancer Res.. 23(1B). 799-802 (2003)

[Publications] 杉村和朗: "臨床医のための腹部血管造影・IVR"新興医学出版社. (2003)

杉村和朗神戸大学, 大学院・医学系研究科, 教授 (00136384)