2005 Fiscal Year Final Research Report Summary
Research on physiological responses in the acute phase of anoxic coma patients
| Project/Area Number |
15390545
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka University |
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Principal Investigator |
SHIOZAKI Tadahiko Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (60278687)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Hisashi Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (90127241)
TANAKA Hiroshi Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助教授 (90252676)
OGURA Hiroshi Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (70301265)
TASAKI Osamu Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (90346221)
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| Project Period (FY) |
2003 – 2005
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| Keywords | Prolonged ischemia / Brain temperature / Cerebral blood flow / Somatosensory evoked potential / Ischemic reperfusion |
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| Research Abstract |
In clinical situation, it takes rather long time to recover the cerebral reperfusion after stroke or cardiac arrest. We, therefore, aimed to identify differences in the postischemic recovery of physiological parameters between short and prolonged brain ischemia.
Eighteen Mongolian gerbils were assigned to one of three groups: 5-minute (G5), 15-minute (G15) and 30-minute (G30) ischemia. With the use of our original microspectroscopy system, global ischemic reperfusion was performed. We measured changes in regional cerebral blood flow (r-CBF), microvessel diameter, and brain temperature (BrT) simultaneously. We also monitered somatosensory evoked potentials (SEPs) to evaluate electrophysiological response.
Both G5 and G 15 showed concurrent recovery of r-CBF and BrT with hyperemia and hyperthermia, respectively, 10-15 minutes after reperfusion. The increase in BrT was < 1 ℃ and recovered to baseline within 60 minutes after reperfusion. In G30, recovery of r-CBF was significantly delayed relative to that of BrT. The increase in BrT was > 2 ℃, peaking approximately 15 minutes after reperfusion, and then remaining > 1 ℃ increased over 120 minutes. SEPs in G5 and G15 showed concomitant recovery with that of r-CBF, whereas SEP recovery in G30 was delayed relative to that of r-CBF, eventually disappearing. All except one of the G30 gerbils died within 24 hours, but all in G5 and G15 survived.
These results suggest that mismatch recovery of r-CBF and BrT after prolonged ischemia initiates metabolic derangement in brain tissue, leading to the electrochemical dysfunction and mortality afterward.
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Research Products
(23 results)
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[Journal Article] Enhanced expression of intracellular heme oxygenase-1 in deactivated monocytes from patients with severe systemic inflammatory response syndrome._2006
Author(s)
Mohri T, Ogura H, Koh T, Fujita K, Sumi Y, Yoshiya K, Matsushima A, Hosotsubo H, Kuwagata Y, Tanaka H, Shimazu T, Sugimoto H
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Journal Title
J Trauma 61
Pages: 616-23
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Altered gut flora and environment in patients with severe SIRS.2006
Author(s)
Shimizu K, Ogura H, Goto M, Asahara T, Nomoto K, Morotomi M, Yoshiya K, Matsushima A, Sumi Y, Kuwagata Y, Tanaka H, Shimazu T, Sugimoto H
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Journal Title
J Trauma 60
Pages: 126-133
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cerebrospinal fluid concentrations of anti-inflammatory mediators in early-phase severe traumatic brain injury.2005
Author(s)
Shiozaki T, Hayakata T, Tazaki O, Hosotubo H, Fujita K, Mouri T, Tajima G, Kajino K, Nakae H, Shimazu T, Tanaka H, Sugimoto H
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The balance between expression of intranuclear NF-kappaB and glucocorticoid receptor in polymorphonuclear leukocytes in SIRS patients.2005
Author(s)
Nakamori Y, Ogura H, Koh T, Fujita K, Tanaka H, Sumi Y, Hosotsubo H, Yoshiya K, Irisawa T, Kuwagata Y, Shimazu T, Sugimoto H
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Journal Title
J Trauma 59
Pages: 308-14
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury.2004
Author(s)
Hayakata T, Shiozaki T, Tazaki 0, Ikegawa H, Inoue Y, Fujinaka T, Hosotubo T, Fujita K, Yamashita T, Tanaka H, Shimazu T, Sugimoto H
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Hepatocyte growth factor in polymorphonuclear leukocytes is increased in patients with systemic inflammatory response syndrome.2004
Author(s)
Matsushima A, Ogura H, Koh T, Fujita K, Yoshiya K, Sumi Y, Hosotsubo H, Kuwagata Y, Tanaka H, Shimazu T, Sugimoto H
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Journal Title
J Trauma 56
Pages: 259-264
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Mismatch Recovery of Regional Cerebral Blood Flow and Brain Temperature during Reperfusion after Prolonged Brain Ischemia in Gerbils.
Author(s)
Tajima, Shiozaki T, Akitoshi Seiyama, Mouri T, Kentaro Kajino, Haruhiko Nakae, Tasaki 0, Ogura H, Kuwagata Y, Tanaka H, Shimazu T, Sugimoto H
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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