2005 Fiscal Year Final Research Report Summary
Investigation of Indonesian Marine Organisms as Medicinal Resources
| Project/Area Number |
15406005
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 海外学術 |
|---|
| Research Field |
Environmental pharmacy
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
KOBAYASHI Motomasa Osaka University, Graduate school of Pharmaceutical Sciences, professor, 薬学研究科, 教授 (40116033)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIGA Tatsuo University of the Ryukyus, Department of Chemistry, Biology, and Marine Science, professor, 理学部, 教授 (10101461)
TANAKA Junichi University of the Ryukyus, Department of Chemistry, Biology, and Marine Science, associate professor, 理学部, 助教授 (20163529)
AOKI Shunji Osaka University, Graduate school of Pharmaceutical Sciences, lecturer, 薬学研究科, 講師 (60252699)
|
|---|
| Project Period (FY) |
2003 – 2005
|
| Keywords | Indonesia / marine invertebrate / medicinal resource / marine sponge / bioactivity |
|---|
| Research Abstract |
Indonesia consists of more than 17,000 islands distributed along the equator stretched over the two oceans. The Indonesian waters are known to have diverse species of sessile organisms such as sponges and soft corals. However, their regional and biological distribution and biomedical potential are scarcely understood. We, a group of scientists from both Indonesia and Japan, aim to conduct survey, collection, and chemical and pharmaceutical investigation of these organisms. Owing to the deterioration of coastal environment caused by industrial and municipal effluents and also by sedimentation of red clay discharged from land development, existence of sessile marine organisms are endangered in the coasts of Japan. This situation is not confined only to Japan. Similar situation is developing in Indonesia, especially along the coasts of Jakarta and other coastal cities. The problem is serious not only from the viewpoint of environmental conservation.
Considering these situations, we started the study of Indonesian marine organisms as sources of lead compounds for new medicines before some of these species disappear from the coastal waters. The present research is carried out as a collaborative project of Pusat Penelitian dan Pengembangan Oseanologi (Research and Development Centre for Oceanology)-LIPI, Lampung University, Diponegoro University, Indonesia and Osaka University and University of the Ryukyus, Japan. We have proceeded survey of marine invertebrates at Lampung in Sumatra Island in 2003, Carita in Java Island in 2004, and Biak Island in 2005 as shown below. 1) Search for diversity and correction of marine invertebrates by SCUBA diving. 2) Isolation of bioactive constituents from those marine invertebrates. We have already isolated several anti-tumor active constituents (cell cycle inhibitor or anti-angiogenesis). 3) Separation of marine microorganism from marine sediment and investigation of bioactive constituents of those marine microorganisms.
|
Research Products
(76 results)
-
-
-
-
-
[Journal Article] Bastadin 6, a spongean brominated tyrosine derivative, inhibits tumor angiogenesis by inducing selective apoptosis to endothelial cells2006
Author(s)
Aoki S, Cho S-H, Ono M, Kuwano T, Nakao S, Kuwano M, Nakagawa S, Gao JQ, Mayumi T, Shibuya M, Kobayashi M
-
Journal Title
ANTI-CANCER DRUGS 17
Pages: 269-278
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex2006
Author(s)
Aoki S, Watanabe Y, Sanagawa M, Setiawan A, Kotoku N, Kobayashi M
-
Journal Title
JOURNAL OF AMERICAN CHEMICAL SOCIETY 128
Pages: 3148-3149
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] MRP1 mutated in the L-0 region transports SN-38 but not leukotriene C-4 or estradiol-17 (beta-D-glucuronate)2005
Author(s)
Noguchi T, Ren XQ, Aoki S, Igarashi Y, Che XF, Nakajima Y, Takahashi H, Mitsuo R, Tsujikawa K, Sumizawa T, Haraguchi M, Kobayashi M, Goto S, Kanehisa M, Aikou T, Akiyama S, Furukawa T
-
Journal Title
BIOCHEMICAL PHARMACOLOGY 70
Pages: 1056-1065
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Binding site(s) on P-glycoprotein for a newly synthesized photoaffinity analog of agosterol A2003
Author(s)
Mitsuo M, Noguchi T, Nakajima Y, Aoki S, Ren X.-Q, Sumizawa T, Haraguchi M, Kobayashi M, Baba M, Nagata Y, Akiyama S, Furukawa T
-
Journal Title
ONCOLOGY RESEARCH 14
Pages: 39-48
Description
「研究成果報告書概要(欧文)」より
-
-
[Journal Article] Malformation of immature starfish oocytes by theonellapeptolide Ie, a tridecapeptide lactone from a marine sponge Petrosia species, through disturbance of cortical F-actin distribution2003
Author(s)
Ohta E, Okada H, Ohta S, Kobayashi M, Kitagawa I, Horiike S, Takahashi T, Hosoya H, Yamamoto K, Ikegami S
-
Journal Title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 67
Pages: 1908-1915
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells2003
Author(s)
Mukai M, Che X.-F, Furukawa T, Sumizawa T, Aoki S, Ren X.-Q, Haraguchi M, Sugimoto Y, Kobayashi M, Takamatsu H, Akiyama S
-
Journal Title
CANCER SCIENCE 94
Pages: 557-563
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
-
