Molecular epidemiological study on the pathogenesis of cholangiocarcinoma caused by infection with liver flukes in Thailand

2005 Fiscal Year Final Research Report Summary

• Project/Area Number: 15406027
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Hygiene
• Research Institution: Mie University
• Principal Investigator: KAWANISHI Shosuke Mie Univeristy, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (10025637)
• Co-Investigator(Kenkyū-buntansha): MURATA Mariko Mie University, Faculty of Medicine, Lecture, 大学院・医学系研究科, 講師 (10171141) ; OIKAWA Shinji Mie University, Faculty of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (10277006) ; HIRAKU Yusuke Mie University, Faculty of Medicine, Lecture, 大学院・医学系研究科, 講師 (30324510)
• Project Period (FY): 2003 – 2005
• Keywords: Opisthorchis viverrini / cholangiocarcinoma / 8-nitroguanine / infection / inflammation / reactive nitrogen species / inducible NO synthase / carcinogenesis

Research Abstract

Infection with the liver fluke Opisthorchis viverrini (OV) is a major risk factor of cholangiocarcinoma especially in north-eastern region of Thailand. Chronic inflammation mediated by infection is an important factor causing cancer. Reactive nitrogen species are generated under inflammatory conditions, and react with guanine to form 8-nitroguanine, a mutagenic nitrative DNA lesion, which may contribute to infection-related carcinogenesis. We produced specific anti-8-nitroguanine antibody, and we firstly demonstrated that 8-nitroguanine was formed in bile duct epithelium of OV-infected hamsters in association with carcinogenesis (BBRC 2003, Nitric Oxide 2004, Carcinogenesis 2004). An antihelminthic drug almost completely diminished iNOS-dependent DNA damage in bile duct epithelium (Int.J.Cancer in press). We carried out a molecular epidemiological study in patients with intrahepatic cholangiocarcinoma. It is noteworthy that 8-nitroguanine formation in surgical specimens of cholangiocar cinoma patients was significantly correlated with tumor invasion, suggesting that DNA damage participates in not only initiation and promotion but also tumor progression (World J.Gastroenterol. 2005). We demonstrated that OV antigen induced inflammatory responses via TLR2-dependent pathway in a macrophage cell line (Int.J.Parasitol. 2005). Our international molecular epidemiological study has provided an insight into molecular mechanisms of a wide variety of inflammation-related carcinogenesis. We also investigated DNA damage in patients with various infectious diseases. 8-Nitroguanine was formed in patients with Helicobacter pylori-induced gastritis (BBRC 2004), chronic hepatitis C (J.Hepatol. 2005) and oral premalignant lesions (Cancer Sci. 2005, Nitric Oxide 2006). We showed that 8-nitroguanine was formed in colon epithelium of the mouse model of inflammatory bowel diseases (Cancer Sci. 2005). In these studies, we found that 8-nitroguanine is formed at the sites of carcinogenesis regardless of etiology, and proposed the possibility that 8-nitroguanine could be a promising biomarker to evaluate the risk and prognosis of inflammation-related carcinogenesis.

Research Products

• [Journal Article] Critical roles for polymerase ζ in cellular tolerance to nitric oxide-induced DNA damage (2006)
  • Author(s): Wu, X.
  • Journal Title: Cancer Res. 66 Pages: 748-754
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 8-Nitroguanine formation in oral leukoplakia, a premalignant lesion (2006)
  • Author(s): Ma, N
  • Journal Title: Nitric Oxide 14 Pages: 137-143
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Radical production and DNA damage induced by carcinogenic 4-hydrazinobenzoic acid, an ingredient of mushroom Agaricus bisporus (2006)
  • Author(s): Oikawa, S.
  • Journal Title: Free Radic. Res. 40 Pages: 31-39
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure (2006)
  • Author(s): Ichihara, S.
  • Journal Title: Cardiovasc. Res. 69 Pages: 726-735
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Guanine-specific DNA damage photosensitized by the dihydroxo (tetraphenylporphyrinato) antimony(V) complex (2006)
  • Author(s): Hirakawa, K.
  • Journal Title: J. Photochem. Photobiol. B 82 Pages: 37-44
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Critical roles for polymerase ζ in cellular tolerance to nitric oxide-induced DNA damage (2006)
  • Author(s): Wu, X., Takenaka, K., Sonoda, E., Hochegger, H., Kawanishi, S., Kawamoto, T., Takeda, S., Yamazoe, M.
  • Journal Title: Cancer Res. 66 Pages: 748-754
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 8-Nitroguanine formation in oral leukoplakia, a premalignant lesion (2006)
  • Author(s): Ma, N., Tagawa, T., Hiraku, Y., Murata, M., Ding, X., Kawanishi, S.
  • Journal Title: Nitric Oxide 14 Pages: 137-143
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Radical production and DNA damage induced by carcinogenic 4-hydrazinobenzoic acid, an ingredient of mushroom Agaricus bisporus (2006)
  • Author(s): Oikawa, S., Ito, T., Iwayama, M., Kawanishi, S.
  • Journal Title: Free Radic.Res. 40 Pages: 31-39
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure (2006)
  • Author(s): Ichihara, S., Noda, A., Nagata, K., Obata, K., Xu, J., Ichihara, G., Oikawa, S., Kawanishi, S., Yamada, Y., Yokota, M.
  • Journal Title: Cardiovasc.Res. 69 Pages: 726-735
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Guanine-specific DNA damage photosensitized by the dihydroxo (tetraphenylporphyrinato) antimony(V) complex (2006)
  • Author(s): Hirakawa, K., Kawanishi, S., Matsumoto, J., Shiragami, T., Yasuda, M.
  • Journal Title: J.Photochem.Photobiol. B82 Pages: 37-44
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 特集 肝と酸化ストレス 酸化ストレスの基礎 (3)酸化・ニトロ化ストレスとDNA傷害 (2005)
  • Author(s): 川西正祐
  • Journal Title: 臨床消化器内科 20 Pages: 421-429
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] DNA障害マーカー (2005)
  • Author(s): 川西正祐
  • Journal Title: 臨床検査 49 Pages: 153-161
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inducible nitric oxide synthase-dependent DNA damage in mouse model of inflammatory bowel disease (2005)
  • Author(s): Ding, X.
  • Journal Title: Cancer Sci. 96 Pages: 157-163
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nitrative and oxidative DNA damage in oral lichen planus in relation to human oral carcinogenesis (2005)
  • Author(s): Chaiyarit, P.
  • Journal Title: Cancer Sci. 96 Pages: 553-559
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Accumulation of 8-nitroguanine in the liver of patients with chronic hepatitis C (2005)
  • Author(s): Horiike, S.
  • Journal Title: J, Hepatol. 43 Pages: 403-410
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Opisthorchis viverrini antigen induces the expression of Toll-like receptor 2 in macrophage RAW cell line (2005)
  • Author(s): Pinlaor, S.
  • Journal Title: Int. J. Parasitol. 35 Pages: 591-596
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion. (2005)
  • Author(s): Pinlaor, S.
  • Journal Title: World J. Gastroenterol. 11 Pages: 4644-4649
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage (2005)
  • Author(s): Sakano, K.
  • Journal Title: Free Radic. Biol. Med. 39 Pages: 1041-1049
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative DNA damage in relation to neurotoxicity in the brain of mice exposed to arsenic at environmentally relevant levels (2005)
  • Author(s): Piao, F.
  • Journal Title: J. Occup. Health 47 Pages: 445-449
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide (2005)
  • Author(s): Mizutani, H.
  • Journal Title: Life Sci 76 Pages: 1439-1453
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Histone peptide SKRHRK enhances H_2O_2-induced DNA damage and alters its site specificity (2005)
  • Author(s): Midorikawa, K.
  • Journal Title: Biochem. Biophys. Res. Commun. 333 Pages: 1073-1077
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Evaluation for safety of antioxidant chemopreventive agents (2005)
  • Author(s): Kawanishi, S.
  • Journal Title: Antioxid. Redox Signal. 7 Pages: 1728-1739
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Amplification of C1027-induced DNA cleavage and apoptosis by a quinacrine-netropsin hybrid molecule in tumor cell lines (2005)
  • Author(s): Iwamoto, T.
  • Journal Title: Arch. Biochem. Biophys. 434 Pages: 232-240
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mechanism of site-specific DNA damage induced by ozone (2005)
  • Author(s): Ito, K.
  • Journal Title: Mutat. Res. 585 Pages: 60-70
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Chemopreventive action of xanthone derivatives on photosensitized DNA damage (2005)
  • Author(s): Hirakawa, K.
  • Journal Title: Photochem. Photobiol. 81 Pages: 314-319
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Guanine-specific DNA damage induced by γ-irradiated histone (2005)
  • Author(s): Furukawa, A.
  • Journal Title: Biochem. J. 388 Pages: 813-818
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inducible nitric oxide synthase-dependent DNA damage in mouse model of inflammatory bowel disease (2005)
  • Author(s): Ding, X., Hiraku, Y., Ma, N., Kato, T., Saito, K., Nagahama, M., Semba, R., Kuribayashi, K., Kawanishi, S.
  • Journal Title: Cancer Sci. 96 Pages: 157-163
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nitrative and oxidative DNA damage in oral lichen planus in relation to human oral carcinogenesis (2005)
  • Author(s): Chaiyarit, P., Ma, N., Hiraku, Y., Pinlaor, S., Yongvanit, P., Jintakanon, D., Murata, M., Oikawa, S., Kawanishi, S.
  • Journal Title: Cancer Sci. 96 Pages: 553-559
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Accumulation of 8-nitroguanine in the liver of patients with chronic hepatitis C (2005)
  • Author(s): Horiike, S., Kawanishi, S., Kaito, M., Ma, N., Tanaka, H., Fujita, N., Iwasa, M., Kobayashi, Y., Hiraku, Y., Oikawa, S., Murata, M., Wang, J., Semba, R., Watanabe, S., Adachi, Y.
  • Journal Title: J.Hepatol. 43 Pages: 403-410
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Opisthorchis viverrini antigen induces the expression of Toll-like receptor 2 in macrophage RAW cell line (2005)
  • Author(s): Pinlaor, S., Tada-Oikawa, S., Hiraku, Y., Pinlaor, P., Ma, N., Sithithaworn, P., Kawanishi, S.
  • Journal Title: Int.J.Parasitol. 35 Pages: 591-596
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion (2005)
  • Author(s): Pinlaor, S., Sripa, B., Ma, N., Hiraku, Y., Yongvanit, P., Wongkham, S., Pairojkul, C., Bhudhisawasdi, V., Oikawa, S., Murata, M., Semba, R., Kawanishi, S.
  • Journal Title: World J.Gastroenterol. 11 Pages: 4644-4649
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage (2005)
  • Author(s): Sakano, K., Mizutani, M., Murata, M., Oikawa, S., Hiraku, Y., Kawanishi.S.
  • Journal Title: Free Radic.Biol.Med. 39 Pages: 1041-1049
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative DNA damage in relation to neurotoxicity in the brain of mice exposed to arsenic at environmentally relevant levels (2005)
  • Author(s): Piao, F., Ma, N., Hiraku, Y., Murata, M., Oikawa, S., Cheng, F., Zhong, L., Yamauchi, T., Kawanishi, S., Yokoyama, K.
  • Journal Title: J.Occup.Health 47 Pages: 445-449
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide (2005)
  • Author(s): Mizutani, H., Tada-Oikawa, S., Hiraku, Y., Kojima, M., Kawanishi, S.
  • Journal Title: Life Sci. 76 Pages: 1439-1453
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Histone peptide AKRHRK enhances H_2O_2-induced DNA damage and alters its site specificity (2005)
  • Author(s): Midorikawa, K., Murata, M., Kawanishi, S.
  • Journal Title: Biochem.Biophys.Res.Commun. 33 Pages: 1073-1077
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evaluation for safety of antioxidant chemopreventive agents (2005)
  • Author(s): Kawanishi, S., Oikawa, S., Murata, M.
  • Journal Title: Antioxid.Redox Signal. 7 Pages: 1728-1739
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Amplification of C1027-induced DNA cleavage and apoptosis by a quinacrine-netropsin hybrid molecule in tumor cell lines (2005)
  • Author(s): Iwamoto, T., Hiraku, Y., Kojima, M., Kawanishi, S.
  • Journal Title: Arch.Biochem.Biophys. 434 Pages: 232-240
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mechanism of site-specific DNA damage induced by ozone (2005)
  • Author(s): Ito, K., Inoue, S., Hiraku, Y., Kawanishi, S.
  • Journal Title: Mutat.Res. 585 Pages: 60-70
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Chemopreventive action of xanthone derivatives on photosensitized DNA damage (2005)
  • Author(s): Hirakawa, K., Yoshida, M., Nagatsu, A., Mizukami, H., Rana, V., Rawat, M.S., Oikawa, S., Kawanishi, S.
  • Journal Title: Photochem.Photobiol. 81 Pages: 314-319
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Guanine-specific DNA damage induced by g-irradiated histone (2005)
  • Author(s): Furukawa, A., Hiraku, Y., Oikawa, S., Luxford, C., Davies, M.J., Kawanishi, S.
  • Journal Title: Biochem.J. 388 Pages: 813-818
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] カテキン類による酸化的DNA損傷 (2004)
  • Author(s): 及川伸二
  • Journal Title: 医学のあゆみ 208 Pages: 688-689
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 酸化ストレスによるクラスターDNA損傷機構とその変異における役割 (2004)
  • Author(s): 及川伸二
  • Journal Title: Environ. Mutagen Res. 26 Pages: 125-133
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini : a model of inflammation-mediated carcinogenesis (2004)
  • Author(s): Pinlaor, S.
  • Journal Title: Nitric Oxide 11 Pages: 175-183
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase (2004)
  • Author(s): Pinlaor, S.
  • Journal Title: Carcinogenesis 25 Pages: 1535-1542
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Accumulation of 8-nitroguanine in human gastric epithelium induced by Helicobacter pylori infection (2004)
  • Author(s): Ma, N.
  • Journal Title: Biochem. Biophys. Res. Commun. 319 Pages: 506-510
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Environmental pollutant tributyltin promotes Th2 polarization and exacerbates airway inflammation (2004)
  • Author(s): Kato, T.
  • Journal Title: Eur. J. Immunol. 34 Pages: 1312-1321
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative DNA damage induced by nitrotyrosine, a biomarker of inflammation (2004)
  • Author(s): Murata, M.
  • Journal Title: Biochem. Biophys. Res. Commun. 316 Pages: 123-128
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative DNA damage induced by benz[a]anthracene dihydrodiols in the presence of dihydrodiol dehydrogenase (2004)
  • Author(s): Seike, K.
  • Journal Title: Chem. Res. Toxicol 17 Pages: 1445-1451
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Copper-mediated oxidative DNA damage induced by eugenol : possible involvement of O-demethylation (2004)
  • Author(s): Sakano, K.
  • Journal Title: Mutat. Res. 565 Pages: 35-44
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative DNA damage induced by a melatonin metabolite, 6-hydroxymelatonin, via a unique non-o-quinone type of redox cycle (2004)
  • Author(s): Sakano, K.
  • Journal Title: Biochem. Pharmacol. 68 Pages: 1869-1878
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mechanism of metal-mediated DNA damage induced by a metabolite of carcinogenic acetamide (2004)
  • Author(s): Sakano, K.
  • Journal Title: Chem. Biol. Interact. 149 Pages: 51-59
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative DNA damage induced by carcinogenic dinitropyrenes in the presence of P450 reductase (2004)
  • Author(s): Murata, M.
  • Journal Title: Chem. Res. Toxicol. 17 Pages: 1750-1756
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative DNA damage induced by a hydroperoxide derivative of cyclophosphamide (2004)
  • Author(s): Murata, M.
  • Journal Title: Free Radic. Biol. Med. 37 Pages: 793-802
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Genistein and daidzein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs (2004)
  • Author(s): Murata, M.
  • Journal Title: Biochemistry 43 Pages: 2569-2577
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Metabolic activation of carcinogenic methylbenzene leads to oxidative DNA damage (2004)
  • Author(s): Midorikawa, K.
  • Journal Title: Chem. Biol. Interact. 150 Pages: 271-281
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Metal-mediated oxidative damage to cellular and isolated DNA by gallic acid, a metabolite of antioxidant propyl gallate (2004)
  • Author(s): Kobayashi, H.
  • Journal Title: Mutat. Res. 558 Pages: 111-120
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Amplification of anticancer drug-induced DNA damage and apoptosis by DNA-binding compounds (2004)
  • Author(s): Kawanishi, S.
  • Journal Title: Curr. Med. Chem. Anti-Canc. Agents 4 Pages: 415-419
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mechanism of telomere shortening by oxidative stress (2004)
  • Author(s): Kawanishi, S.
  • Journal Title: Ann. NY Acad. Sci. 1019 Pages: 278-284
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect (2004)
  • Author(s): Iwamoto, T.
  • Journal Title: Cancer Sci. 95 Pages: 454-458
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mechanism of carcinogenesis induced by a veterinary antimicrobial drug, nitrofurazone, via oxidative DNA damage and cell proliferation (2004)
  • Author(s): Hiraku, Y.
  • Journal Title: Cancer Lett. 215 Pages: 141-150
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Photo-irradiated titanium dioxide catalyzes site specific DNA damage via generation of hydrogen peroxide (2004)
  • Author(s): Hirakawa, K.
  • Journal Title: Free Radic. Res. 38 Pages: 439-447
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini : a model of inflammation-mediated carcinogenesis (2004)
  • Author(s): Pinlaor, S., Hiraku, Y., Ma, N., Yongvanit, P., Semba, R., Oikawa, S., Murata, M., Sripa, B., Sithithaworn, P., Kawanishi, S.
  • Journal Title: Nitric Oxide 11 Pages: 175-183
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase (2004)
  • Author(s): Pinlaor, S., Ma, N., Hiraku, Y., Yongvanit, P., Semba, R., Oikawa, S., Murata, M., Sripa, B., Sithithaworn, P., Kawanishi, S.
  • Journal Title: Carcinogensis 25 Pages: 1535-1542
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Accumulation of 8-nitroguanine in human gastric epithelium induced by Helicobacter pylori infection (2004)
  • Author(s): Ma, N., Adachi, Y., Hiraku, Y., Horiki, N., Horiike, S., Imoto, I., Pinlaor, S., Murata, M., Semba, R., Kawanishi, S.
  • Journal Title: Biochem.Biophys.Res.Commun. 319 Pages: 506-510
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Environmental pollutant tributyltin promotes Th2 polarization and exacerbates airway inflammation (2004)
  • Author(s): Kato, T., Uchikawa, R., Yamada, M., Arizono, N., Oikawa, S., Kawanishi, S., Nishio, A., Nakase, H., Kuribayashi, K.
  • Journal Title: Eur.J.Immunol. 34 Pages: 1312-1321
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative DNA damage induced by nitrotyrosine, a biomarker of inflammation (2004)
  • Author(s): Murata, M., Kawanishi, S.
  • Journal Title: Biochem.Biophys.Res.Commun. 316 Pages: 123-128
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative DNA damage induced by benz[a]anthracene dihydrodiols in the presence of dihydrodiol dehydrogenase (2004)
  • Author(s): Seike, K., Murata, M., Hirakawa, K., Deyashiki, Y., Kawanishi, S.
  • Journal Title: Chem.Res.Toxicol. 17 Pages: 1445-1451
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Copper-mediated oxidative DNA damage induced by eugenol : possible involvement of 0-demethylation (2004)
  • Author(s): Sakano, K., Inagaki, Y., Oikawa, S., Hiraku, Y., Kawanishi, S.
  • Journal Title: Mutat.Res. 565 Pages: 35-44
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative DNA damage induced by a melatonin metabolite, 6-hydroxy-melatonin, via a unique non-o-quinone type of redox cycle (2004)
  • Author(s): Sakano, K., Oikawa, S., Hiraku, Y., Kawanishi, S.
  • Journal Title: Biochem.Pharmacol. 68 Pages: 1869-1878
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mechanism of metal-mediated DNA damage induced by a metabolite of carcinogenic acetamide (2004)
  • Author(s): Sakano, K., Oikawa, S., Hiraku, Y., Kawanishi, S.
  • Journal Title: Chem.Biol.Interact. 149 Pages: 51-59
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative DNA damage induced by carcinogenic dinitropyrenes in the presence of P450 reductase (2004)
  • Author(s): Murata, M., Ohnishi, S., Seike, K., Fukuhara, K., Miyata, N., Kawanishi, S.
  • Journal Title: Chem.Res.Toxicol. 17 Pages: 1750-1756
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative DNA damage induced by a hydroperoxide derivative of cyclophosphamide (2004)
  • Author(s): Murata, M., Suzuki, T., Midorikawa, K., Oikawa, S., Kawanishi, S.
  • Journal Title: Free Radic.Biol.Med. 37 Pages: 793-802
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Genistein and daidzein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs (2004)
  • Author(s): Murata, M., Midorikawa, K., Koh, M., Umezawa, K., Kawanishi, S.
  • Journal Title: Biochemistry 43 Pages: 2569-2577
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Metabolic activation of carcinogenic ethylbenzene leads to oxidative DNA damage (2004)
  • Author(s): Midorikawa, K., Uchida, T., Okamoto, Y., Toda, C., Sakai, Y., Ueda, K., Hiraku, Y., Murata, M., Kawanishi, S., Kojima, N.
  • Journal Title: Chem.Biol.Interact. 150 Pages: 271-281
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Metal-mediated oxidative damage to cellular and isolated DNA by gallic acid, a metabolite of antioxidant propyl gallate (2004)
  • Author(s): Kobayashi, H., Oikawa, S., Hirakawa, K., Kawanishi, S.
  • Journal Title: Mutat.Res. 558 Pages: 111-120
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Amplification of anticancer drug-induced DNA damage and apoptosis by DNA-binding compounds (2004)
  • Author(s): Kawanishi, S., Hiraku, Y.
  • Journal Title: Curr.Med.Chem.Anti-Canc.Agents 4 Pages: 415-419
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mechanism of telomere shortening by oxidative stress (2004)
  • Author(s): Kawanishi, S., Oikawa, S.
  • Journal Title: Ann.NY Acas.Sci. 1019 Pages: 278-284
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect (2004)
  • Author(s): Iwamoto, T., Hiraku, Y., Oikawa, S., Mizutani, H., Kojima, M., Kawanishi, S.
  • Journal Title: Cancer Sci. 95 Pages: 454-458
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mechanism of carcinogenesis induced by a veterinary antimicrobial drug, nitrofurazone, via oxidative DNA damage and cell proliferation (2004)
  • Author(s): Hiraku, Y., Sekine, A., Nabeshi, H., Midorikawa, K., Murata, M., Kumagai, Y., Kawanishi, S.
  • Journal Title: Cancer Lett. 215 Pages: 141-150
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Photo-irradiated titanium dioxide catalyzes site specific DNA damage via generation of hydrogen peroxide (2004)
  • Author(s): Hirakawa, K., Mori, M., Yoshida, M., Oikawa, S., Kawanishi, S.
  • Journal Title: Free Radic.Res. 38 Pages: 439-447
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 8-Nitroguanine formation in the liver of hamsters infected with Opisthorchis viverrini (2003)
  • Author(s): Pinlaor, S.
  • Journal Title: Biochem. Biophys. Res. Commun. 309 Pages: 567-571
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] DNA damage by ethylbenzenehydroperoxide formed from carcinogenic ethylbenzene by sunlight irradiation (2003)
  • Author(s): Toda, C.
  • Journal Title: Biochem. Biophys. Res. Commun. 304 Pages: 638-642
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis (2003)
  • Author(s): Tada-Oikawa, S.
  • Journal Title: Life Sci. 73 Pages: 3277-3288
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative DNA damage induced by benz[a]anthracene metabolites via redox cycles of quinone and unique non-quinone (2003)
  • Author(s): Seike, K.
  • Journal Title: Chem. Res. Toxicol. 16 Pages: 1470-1476
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species (2003)
  • Author(s): Oikawa, S.
  • Journal Title: Free Radic. Res. 37 Pages: 881-890
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative damage to cellular and isolated DNA by homocysteine : implications for carcinogenesis (2003)
  • Author(s): Oikawa, S.
  • Journal Title: Oncogene 22 Pages: 3530-3538
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Molecular mechanisms of DNA damage induced by procarbazine in the presence of Cu(II). (2003)
  • Author(s): Ogawa, K.
  • Journal Title: Mutat. Res. 539 Pages: 145-155
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Vacuolar H^+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1 (2003)
  • Author(s): Nakashima, S.
  • Journal Title: J. Biochem. (Tokyo) 134 Pages: 359-364
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative DNA damage induced by toluene is involved in its male reproductive toxicity (2003)
  • Author(s): Nakai, N.
  • Journal Title: Free Radic. Res. 37 Pages: 69-76
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative DNA damage by hyperglycemia-related aldehydes and its marked enhancement by hydrogen peroxide (2003)
  • Author(s): Murata, M.
  • Journal Title: FEBS Lett. 554 Pages: 138-142
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Distinct mechanisms of site-specific oxidative DNA damage by doxorubicin in the presence of copper(II) and NADPH-cytochrome P450 reductase (2003)
  • Author(s): Mizutani, H.
  • Journal Title: Cancer Sci. 94 Pages: 686-691
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative DNA damage induced by photodegradation products of 3'-azido-3'-deoxythymidine (2003)
  • Author(s): Iwamoto, T.
  • Journal Title: Arch. Biochem. Biophys. 416 Pages: 155-163
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Base oxidation at 5' site of GG sequence in double-stranded DNA induced by UVA in the presence of xanthone analogues : relationship between the DNA-damaging abilities of photosensitizers and their HOMO energies (2003)
  • Author(s): Hirakawa, K.
  • Journal Title: Photochem. Photobiol. 77 Pages: 349-355
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Carcinogenic semicarbazide induces sequence-specific DNA damage through the generation of reactive oxygen species and the derived organic radicals (2003)
  • Author(s): Hirakawa, K.
  • Journal Title: Mutat. Res. 536 Pages: 91-101
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Sequence-specific DNA damage induced by ultraviolet A-irradiated folic acid via its photolysis product (2003)
  • Author(s): Hirakawa, K.
  • Journal Title: Arch. Biochem. Biophys. 410 Pages: 261-268
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] (-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA (2003)
  • Author(s): Furukawa, A.
  • Journal Title: Biochem. Pharmacol. 66 Pages: 1769-1778
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 8-Nitroguanine formation in the liver of hamsters infected with Opisthorchis viverrini (2003)
  • Author(s): Pinlaor, S., Yongvanit, P., Hiraku, Y., Ma, N., Semba, R., Oikawa, S., Murata, M., Sripa, B., Sithithaworn, P., Kawanishi, S.
  • Journal Title: Biochem.Biophys.Res.Commun. 309 Pages: 567-571
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] DNA damage by ethylbenzenehydro-peroxide formed from carcinogenic ethylbenzene by sunlight irradiation (2003)
  • Author(s): Toda, C., Uchida, T., Midorikawa, K., Murata, M., Hiraku, Y., Okamoto, Y., Ueda, K., Kojima, N., Kawanishi, S.
  • Journal Title: Biochem.Biophys.Res.Commun. 304 Pages: 638-642
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis (2003)
  • Author(s): Tada-Oikawa, S., Hiraku, Y., Kawanishi, M., Kawanishi, S.
  • Journal Title: Life Sci. 73 Pages: 3277-3288
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative DNA damage induced by berz[a]anthracene metabolites via redox cycles of quinone and unique non-quinone (2003)
  • Author(s): Seike, K., Murata, M., Oikawa, S., Hiraku, Y., Hirakawa, K., Kawanishi S.
  • Journal Title: Chem.Res.Toxicol. 16 Pages: 1470-1476
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species (2003)
  • Author(s): Oikawa, S., Furukawa, A., Asada, H., Hirakawa, K., Kawanishi, S.
  • Journal Title: Free Radic.Res. 37 Pages: 881-890
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative damage to cellular and isolated DNA by homocysteine : implications for carcinogenesis (2003)
  • Author(s): Oikawa, S., Murakami, K., Kawanishi, S.
  • Journal Title: Oncogene 22 Pages: 3530-3538
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular mechanisms of DNA damage induced by procarbazine in the presence of Cu(II) (2003)
  • Author(s): Ogawa, K., Hiraku, Y., Oikawa, S., Murata, M., Sugimura, Y., Kawamura, J., Kawanishi, S.
  • Journal Title: Mutat.Res. 539 Pages: 145-155
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Vacuolar H^+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1 (2003)
  • Author(s): Nakashima, S., Hiraku, Y., Tada-Oikawa, S., Hishita, T., Gabazza, E.C., Tamaki, S., Imoto, I., Adachi, Y., Kawanishi, S.
  • Journal Title: J.Biochem. (Tokyo) 134 Pages: 359-364
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative DNA damage induced by toluene is involved in its male reproductivetoxicity (2003)
  • Author(s): Nakai, N., Murata, M., Nagahama, M., Hirase, T., Tanaka, M., Fujikawa, T., Nakao, N., Nakashima, K., Kawanishi, S.
  • Journal Title: Free Radic.Res. 37 Pages: 69-76
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative DNA damage by hyperglycemia-related aldehydes and its marked enhancement by hydrogen peroxide (2003)
  • Author(s): Murata, M., Mizutani, M., Oikawa, S., Hiraku, Y., Kawanishi, S.
  • Journal Title: FEBS Lett. 554 Pages: 138-142
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Distinct mechanisms of site-specific oxidative DNA damage by doxorubicin in the presence of copper(II) and NADPH-cytochrome P450 reductase (2003)
  • Author(s): Mizutani, H., Oikawa, S., Hiraku, Y., Murata, M., Kojima, M., Kawanishi, S.
  • Journal Title: Cancer Sci. 94 Pages: 686-691
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative DNA damage induced by photodegradation products of 3'-azido-3'-deoxythymidine (2003)
  • Author(s): Iwamoto, T., Hiraku, Y., Oikawa, S., Mizutani, H., Kojima, M., Kawanishi, S.
  • Journal Title: Arch.Biochem.Biophys. 416 Pages: 155-163
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Base oxidation at 5' site of GG sequence in double-stranded DNA induced by UVA in the presence of xanthone analogues : relationship between the DNA-damaging abilities of photosensitizers and their HOMO energies (2003)
  • Author(s): Hirakawa, K., Yoshida, M., Oikawa, S., Kawanishi, S.
  • Journal Title: Photochem.Photobiol. 77 Pages: 349-355
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Carcinogenic semicarbazide induces sequence-specific DNA damage through the generation of reactive oxygen species and the derived organic radicals (2003)
  • Author(s): Hirakawa, K., Midorikawa, K., Oikawa, S., Kawanishi, S.
  • Journal Title: Mutat.Res. 536 Pages: 91-101
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sequence-specific DNA damage induced by ultraviolet A-irradiated folic acid via its photolysis product (2003)
  • Author(s): Hirakawa, K., Suzuki, H., Oikawa, S., Kawanishi, S.
  • Journal Title: Arch.Biochem.Biophys. 410 Pages: 261-268
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] (-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA (2003)
  • Author(s): Furukawa, A., Oikawa, S., Murata, M., Hiraku, Y., Kawanishi, S.
  • Journal Title: Biochem.Pharmacol. 66 Pages: 1769-1778
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] iNOS-dependent DNA damage via NF-κB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel
  • Author(s): Pinlaor, S.
  • Journal Title: Int. J. Cancer (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation
  • Author(s): Kawanishi, S.
  • Journal Title: Antioxid. Redox Signal. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mechanism of DNA damage induced by bromate differs from general types of oxidative stress
  • Author(s): Kawanishi, S.
  • Journal Title: Toxicology (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis
  • Author(s): Kawanishi, S.
  • Journal Title: Biol. Chem. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] iNOS-dependent DNA damage via NF-κB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel
  • Author(s): Pinlaor, S., Hiraku, Y., Yongvanit, P., Tada-Oikawa, S., Ma, N., Pinlaor, P., Sithithaworn, P., Sripa, B., Murata, M., Oikawa, S., Kawanishi, S.
  • Journal Title: Int.J.Cancer (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation
  • Author(s): Kawanishi, S., Hiraku, Y.
  • Journal Title: Antioxid.Redox Signal. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mechanism of DNA damage induced by bromate differs from general types of oxidative stress
  • Author(s): Kawanishi, S., Murata, M.
  • Journal Title: Toxicology (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis
  • Author(s): Kawanishi, S., Hiraku, Y., Pinlaor, S., Ma, N.
  • Journal Title: Biol.Chem. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 酸化ストレスマーカー(二木鋭雄 他編) (2005)
  • Author(s): 及川伸二
  • Total Pages: 296
  • Publisher: 学会出版センター
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 予防医学事典(松島綱治 他編) (2005)
  • Author(s): 川西正祐
  • Total Pages: 445
  • Publisher: 朝倉書店
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 分子予防環境医学(分子予防環境医学研究会編) (2003)
  • Author(s): 及川伸二
  • Total Pages: 768
  • Publisher: 本の泉社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 食と生活習慣病(菅原努 監修) (2003)
  • Author(s): 及川伸二
  • Total Pages: 213
  • Publisher: 昭和堂
  • Description: 「研究成果報告書概要(和文)」より