2004 Fiscal Year Final Research Report Summary
Neural mechanism for the formation of long-tem memory in the primate rhinal cortex
| Project/Area Number |
15500206
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
NAYA Yuji The University of Tokyo, School of Medicine, Physiology, Lecturer, 大学院・医学系研究科, 講師 (90272418)
|
|---|
| Project Period (FY) |
2003 – 2004
|
| Keywords | Visual Memory / Temporal Lobe / Distracter Stimulus / Long-term Memory / Short-tem Memory / Working Memory / Single-Unit Recording / Primate |
|---|
| Research Abstract |
The macaque inferotemporal cortex is involved in encoding and retrieval of visual long-term memory. We previously recorded neural responses of the macaque inferotemporal cortex during pair association task and found that the delay-period activity reflected the cue stimulus itself or its paired associate. In this study, distractor stimuli were introduced in the middle of a delay period during a pair-association task, and the signal content was compared between the delay period before and after distractor presentation by multiple regression analysis. In 37 out of the 59 delay selective neurons in monkey mferotemporal cortex, partial regression coefficient (β) for cue stimuli was significantly positive (p<0.01) before distractors appeared. However, in only 7 neurons, β for cue stimuli was significantly positive after distractors appeared. On the other hand, the numbers of neurons with significantly positive β for target stimuli were comparable before and after distractors appeared (29 and 27 neurons, respectively). We also found that β for distractor stimuli was significantly positive in 23 neurons. We conclude that the effect of target stimuli sustained after distractors appeared while the effect of cue stimuli attenuated, and that distractor stimuli affected the subsequent delay activity.
|
Research Products
(10 results)
