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2006 Fiscal Year Final Research Report Summary

Study of dynamic changes in urinary bicarbonate and NOx during local and systemic exercise and significance of these factors as fatigue indices after exercise

Research Project

Project/Area Number 15500458
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionTokyo Medical University

Principal Investigator

TOMODA Akio  Tokyo Medical University, Department of Biochemistry, Professor, 医学部, 教授 (10092793)

Co-Investigator(Kenkyū-buntansha) SHIMOMITSU Teruichi  Tokyo Medical University, Department of Preventive Medicine, Professor, 医学部, 教授 (90206243)
ABE Akihisa  Tokyo Medical University, Department of Biochemistry, Associate, 医学部, 助教 (30201289)
Project Period (FY) 2003 – 2006
Keywordssystemic exercise / local exercise / urinary bicarbonate / urinary pH / intraerythrocytic pH
Research Abstract

We investigated the changes in various physiological factors, blood lactate, urinary NOx, urinary bicarbonate and urinary pH during quantitative and heavy exercise (local and systemic repetition exercises) and after the termination of the exercise, in healthy male adults. Furthermore, we studied the effects of cooling-down exercise on changes in these physiological parameters after the termination of heavy exercises. Based on these results, dynamics of blood NO and bicarbonate, changes in blood and erythrocytic pH were deduced, and physiological significance and the significance in exercise medicine of these parameters were inspected.As a result, it was found that urinary bicarbonate increased within 3 hours after the termination of exercises, accompanying with the increment of urinary pH. These results were explained by the facts that blood lactate accumulated during heavy exercises was metabolized to carbon dioxide, which was further metabolized to bicarbonate in the blood. Bicarbonate was finally excreted into the urine. As these reactions proceed, a large amount of hydrogen ion was left in the erythrocytes causing decreased oxygen affinity of hemoglobin, and finally inducing systemic cyanosis. These processes could be considered to be associated with fatigue after heavy exercise. When cooling-down exercise was introduced, no increase of urinary bicarbonate was observed, suggesting that the internal circumstances in the body would be improved by cooling-down. Present study suggested that the decrease of intraerythrocytic pH, which is easily deduced from urinary bicarbonate, might be important as a fatigue factor after heavy exercise.

  • Research Products

    (10 results)

All 2007 2006 2004

All Journal Article (10 results)

  • [Journal Article] Cooling down causes rapid consumption of blood lactate and no increase of urinary bicarbonate2007

    • Author(s)
      T.Moriguchi, K.Shirato, A.Tomoda
    • Journal Title

      Advances in Exercise and Sports Physiology (in submission)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] B2-Agonist, clenbuterol induced distribution changes of the number of white blood cells in rats2007

    • Author(s)
      K.Shirato, A.Tomoda
    • Journal Title

      J. Pharmacol. Sci. (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cooling-down causes rapid consumption of blood lactate and no increase of urinary bicarbonate2007

    • Author(s)
      T.Moriguchi, K.Shirato, K.Imaizumi, R.Izumi, A.Tomoda
    • Journal Title

      Advances in Exercise and Sports Physiology (in submission)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] β2-Agonist, clenbuterol induced distribution changes of the number of white blood cells in rats2007

    • Author(s)
      K.Shirato, A.Tomoda, K.Imaizumi
    • Journal Title

      J.Pharmacol.Sci. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effects of two types of inactivity on the number of white blood cells in rats2006

    • Author(s)
      K.Shirato, A.Tomoda, K.Imaizumi
    • Journal Title

      Euro. J. Appl. Physiol. 98

      Pages: 590-600

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Effects of two types of inactivity on the number of white blood cells in rats2006

    • Author(s)
      K.Shirato, N, Motohashi, J.Tanihata, K.Tachiyashiki, A.Tomoda, K.Imaizumi
    • Journal Title

      Euro.J.Appl.Physiol. 98

      Pages: 590-600

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Ten-year-study on atmospheric carbon dioxide in Tokyo performed by students annually2004

    • Author(s)
      A.Tomoda
    • Journal Title

      Journal of Tokyo Medical University 62

      Pages: 641-647

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Significance of post exercise increment of urinary bicarbonate in subjects loaded with submaximal cycling exercise2004

    • Author(s)
      T.Moriguchi, A.Tomoda
    • Journal Title

      Tohoku J. Exp.Med 202

      Pages: 203-211

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Ten-year-study on atmospheric carbon dioxide in Tokyo performed by students annually involved in 2 weeks of environmental research2004

    • Author(s)
      A.Tomoda
    • Journal Title

      Journal of Tokyo Medical University 62

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Significance of post-exercise increment of urinary bicarbonate and pH in subjects loaded with submaximal cycling exercise2004

    • Author(s)
      T.Moriguchi, A.Tomoda, S.Ichimura, Y.Odagiri, S.Inoue, T.Nagasawa, H.Tanaka, N.Nakagawa, T.Shimomitsu
    • Journal Title

      Tohoku J.Exp.Med. 202

      Pages: 203-211-

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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