2004 Fiscal Year Final Research Report Summary
Effects of exercise training on age-related muscle atrophy and bone loss and their countermeasures
| Project/Area Number |
15500478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kyoto University |
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Principal Investigator |
ISHIHARA Akihiko Kyoto University, Graduate School of Human and Environmental Studies, Professor, 大学院・人間・環境学研究科, 教授 (90184548)
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| Project Period (FY) |
2003 – 2004
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| Keywords | Aging / Muscle Strength / Osteopenia |
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| Research Abstract |
Sixty-, 70-, and 80-years old healthy women were subjected to exercise training with their 50, 70, or 100% of maximal voluntary knee extension for 8 weeks. Maximal muscle strength at 60- and 70-years-old women was higher than that at 80-years-old women after exercise training with their 100% of maximal contraction. In contrast, there was no difference in maximal muscle strength among 60-, 70-, and 80-years-old women after their 50 and 70% of maximal contraction. There was no difference in bone density among three groups, irrespective the type of exercise training. An age-related decline in maximal muscle strength was prevented by exercise training with their maximal effort. In contrast, a decrease in bone density was not prevented by exercise training. It is concluded that exercise training at higher strength is effective for muscle strength, but not for bone density. Effects of voluntary running exercise on skeletal muscle and bone in senescence accelerated mouse prone 6 (SAMP6) were investigated. An age-related atrophy in muscle fibers was prevented by exercise training. In addition, an osteopenia was inhibited by exercise training. It is suggested that exercise training is effective for age-related changes in musculoskeletal systems.
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Research Products
(8 results)
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[Journal Article] Effects of running exercise during recovery from hindlimb unloading on soleus muscle fibers and spinal motoneurons in rats2004
Author(s)
Ishihara, A., Kawano, F., Ishioka, N., Oishi, H., Higashibata, A., Shimazu, T., Ohira, Y.
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Journal Title
Neurosci.Res. 48
Pages: 119-127
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effects of aging and exercise on density and cross-sectional area of femur in senescence-accelerated mouse prone 62003
Author(s)
Ishihara, A., Roy, R.R., Ohira, Y., Kawano, F., Nonaka, K., Yamamoto, K., Edgerton, V.R.
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Journal Title
J.Musculoskel.Neuron.Int. 3
Pages: 162-169
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Growth-related changes in cell body size and succinate dehydrogenase activity of spinal motoneurons innervating the rat soleus muscle2003
Author(s)
Ishihara, A., Kawano, F., Ishioka, N., Oishi, H., Higashibata, A., Shimazu, T., Ohira, Y.
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Journal Title
Int.J.Dev.Neurosci. 21
Pages: 461-469
Description
「研究成果報告書概要(欧文)」より
