2005 Fiscal Year Final Research Report Summary
Development of porous membranes of poly (lactic acid) via thermally induced phase separation and its application to bioprocesses
| Project/Area Number |
15560673
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Niigata University |
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Principal Investigator |
TANAKA Takaaki Niigata University, Institute of Science and Technology, Associate Professor, 自然科学系, 助教授 (00217043)
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| Co-Investigator(Kenkyū-buntansha) |
TANIGUCHI Masayuki Niigata University, Institute of Science and Technology, Professor, 自然科学系, 教授 (00163634)
AOKI Toshiki Niigata University, Institute of Science and Technology, Professor, 自然科学系, 教授 (80212372)
MATSUYMA Hideto Kobe University, Faculty of Engineering, Professor, 工学部, 教授 (50181798)
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| Project Period (FY) |
2003 – 2005
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| Keywords | poly (lactic acid) / separation membrane / thermally induced phase separation / porous |
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| Research Abstract |
Biodegradable polyesters, e.g., poly(_L-lactic acid), which are degraded by microorganisms in natural environment and degradable in human bodies, have recently received increased attention in bioengineering. In this study we have developed microporous membranes of biodegradable polyesters via thermally induced phase separation. At first effect of characteristics of polymers and conditions of phase separation (diluent, polymer concentration, and thermal history) on the growth of the droplet in phase separation and the structures and pore sizes of the formed porous materials. Then, we made microporous membranes of poly(_L-lactic acid), poly(ε-caprolactone), and their blends. The poly(_L-lactic acid) membrane showed the characteristics of a screen filter in the filtration of yeast cell suspensions. The membrane of a polymer blend of poly(_L-lactic acid) and poly(ε-caprolactone) showed that of a depth filter. The filtration flux with the latter membrane was much higher than that with the former. We also applied poly(_L-lactic acid) membrane to the production of an oxidase, laccase, by membrane-surface liquid culture of white rot fungus, Trametes versicolor. The membrane was stable at 28℃ and the fungus grown on the membrane secreted much more enzyme in the repeated use of membrane-surface liquid culture than in liquid surface culture. The porous biodegradable membranes would contribute to the development of sustainable bioindustry and biomedical engineering.
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[Journal Article] Formation of biodegradable microporous materials via thermally induced phase separation (in Japanese).2006
Author(s)
T.Tanaka, T.Aoki, S.Eguchi, T.Aoki, H.Matsuyama, M.Taniguchi, D.R.Lloyd
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Journal Title
Subdivision of Medical Engineering, Division of Biochemical Engineering, Society of Chemical Engineers of Japan, ed., Chemical Engineering Symposium Series 79,"Chemical Engineering on Diagnostic and Therapeutic Systems,"
Pages: 46-51
Description
「研究成果報告書概要(欧文)」より
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